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• W2947607777 endingPage "1382" @default.
• W2947607777 startingPage "1368" @default.
• W2947607777 abstract "Recent studies have demonstrated that dermal papilla cell-derived exosomes (DPC-Exos) promote the anagen stage of hair follicle (HF) growth and delay the catagen stage. However, the roles of DPC-Exos in regulating hair follicle stem cell (HFSC) quiescence and activation remain unknown. Here, we found that HFSC differentiation was induced by co-culture with DPCs, and that DPC-Exos attached to the surface of HFSCs. Using micro RNA (miRNA) high-throughput sequencing, we identified 111 miRNAs that were significantly differentially expressed between DPC-Exos and DPCs, and the predicted target genes of the top 34 differentially expressed miRNAs indicated that DPC-Exos regulate HFSCs proliferation and differentiation via genes involved in cellular signal transduction, fatty acid expression regulation, and cellular communication. The overexpression of miR-22-5p indicated that it negatively regulates HFSC proliferation and LEF1 was revealed as the direct target gene of miR-22-5p. We therefore propose the miR-22-5p-LEF1 axis as a novel pathway regulating HFSC proliferation." @default.
• W2947607777 created "2019-06-07" @default.
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• W2947607777 date "2019-01-01" @default.
• W2947607777 modified "2023-10-16" @default.
• W2947607777 title "Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation" @default.
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• W2947607777 doi "https://doi.org/10.7150/ijbs.33233" @default.
• W2947607777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6643152" @default.
• W2947607777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31337968" @default.
• W2947607777 hasPublicationYear "2019" @default.
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