Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947609966> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2947609966 abstract "Background: The accumulation of late apoptotic or so-called Secondary NEcrotic Cells (SNEC) in germinal centers challenges B and T cell tolerance and leads to the development of autoimmunity and the production of autoantibodies. Objectives: Determine the test performance of immobilized SNEC autoantigens for the diagnosis of Systemic Lupus Erythematosus. Methods: SNEC ELISA of sera from patients with SLE and test performance statistics were deployed to evaluate the diagnostic potential SNEC-derived autoantigens. Functional assays confirmed its pathophysiological relevance. Results: SNEC contains nuclear autoantigens bearing apoptosis-associated modifications such as histone H3 K27me3, histone H2A/H4AcK8,12,16, and histone H2B-AcK12. The SNEC ELISA clearly discriminated patients with SLE from patients with Rheumatoid Arthritis (RA), Primary Anti-Phospholipid Syndrome (PAPS), Spondyloarthropathy (SpA), Psoriatic Arthritis (PsA), and Systemic Sclerosis (SSc). A positive test result in SNEC ELISA significantly correlated with serological variables and reflected the uptake of opsonized SNEC by neutrophils in the blood. Conclusion: SNEC ELISA allows for the sensitive detection of pathologically relevant autoantibodies in the serum of patients with SLE. The clearance of nuclear remnants by neutrophils enhances inflammatory responses supporting the role of clearance deficiency in the etiopathogenesis of SLE. Reference: [1] Biermann MHC, Boeltz S, Pieterse E, Knopf J, Rech J, Bilyy R, van der Vlag J, Tincani A, Distler JHW, Kronke G, Schett GA, Herrmann M and Munoz LE (2018) Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus. Front. Immunol. 9:989. doi: 10.3389/fimmu.2018.00989 Disclosure of Interests: None declared" @default.
- W2947609966 created "2019-06-07" @default.
- W2947609966 creator A5004556215 @default.
- W2947609966 date "2019-06-01" @default.
- W2947609966 modified "2023-09-27" @default.
- W2947609966 title "SP0174 ADVANCES IN THE DETECTION OF PATHOGENIC AUTOANTIBODIES IN SLE" @default.
- W2947609966 doi "https://doi.org/10.1136/annrheumdis-2019-eular.8544" @default.
- W2947609966 hasPublicationYear "2019" @default.
- W2947609966 type Work @default.
- W2947609966 sameAs 2947609966 @default.
- W2947609966 citedByCount "0" @default.
- W2947609966 crossrefType "proceedings-article" @default.
- W2947609966 hasAuthorship W2947609966A5004556215 @default.
- W2947609966 hasBestOaLocation W29476099661 @default.
- W2947609966 hasConcept C126322002 @default.
- W2947609966 hasConcept C159654299 @default.
- W2947609966 hasConcept C163764329 @default.
- W2947609966 hasConcept C203014093 @default.
- W2947609966 hasConcept C2776260265 @default.
- W2947609966 hasConcept C2776661782 @default.
- W2947609966 hasConcept C2776912625 @default.
- W2947609966 hasConcept C2777077863 @default.
- W2947609966 hasConcept C2777575956 @default.
- W2947609966 hasConcept C2778453870 @default.
- W2947609966 hasConcept C2779134260 @default.
- W2947609966 hasConcept C2780130043 @default.
- W2947609966 hasConcept C71924100 @default.
- W2947609966 hasConcept C96926380 @default.
- W2947609966 hasConceptScore W2947609966C126322002 @default.
- W2947609966 hasConceptScore W2947609966C159654299 @default.
- W2947609966 hasConceptScore W2947609966C163764329 @default.
- W2947609966 hasConceptScore W2947609966C203014093 @default.
- W2947609966 hasConceptScore W2947609966C2776260265 @default.
- W2947609966 hasConceptScore W2947609966C2776661782 @default.
- W2947609966 hasConceptScore W2947609966C2776912625 @default.
- W2947609966 hasConceptScore W2947609966C2777077863 @default.
- W2947609966 hasConceptScore W2947609966C2777575956 @default.
- W2947609966 hasConceptScore W2947609966C2778453870 @default.
- W2947609966 hasConceptScore W2947609966C2779134260 @default.
- W2947609966 hasConceptScore W2947609966C2780130043 @default.
- W2947609966 hasConceptScore W2947609966C71924100 @default.
- W2947609966 hasConceptScore W2947609966C96926380 @default.
- W2947609966 hasLocation W29476099661 @default.
- W2947609966 hasOpenAccess W2947609966 @default.
- W2947609966 hasPrimaryLocation W29476099661 @default.
- W2947609966 hasRelatedWork W1971204047 @default.
- W2947609966 hasRelatedWork W1975132493 @default.
- W2947609966 hasRelatedWork W1993266644 @default.
- W2947609966 hasRelatedWork W2016581235 @default.
- W2947609966 hasRelatedWork W2017321652 @default.
- W2947609966 hasRelatedWork W2045423882 @default.
- W2947609966 hasRelatedWork W2046485180 @default.
- W2947609966 hasRelatedWork W2123667712 @default.
- W2947609966 hasRelatedWork W2151574372 @default.
- W2947609966 hasRelatedWork W2163409981 @default.
- W2947609966 hasRelatedWork W2328185895 @default.
- W2947609966 hasRelatedWork W2394712006 @default.
- W2947609966 hasRelatedWork W2470895786 @default.
- W2947609966 hasRelatedWork W2748689 @default.
- W2947609966 hasRelatedWork W2794117339 @default.
- W2947609966 hasRelatedWork W2802478135 @default.
- W2947609966 hasRelatedWork W2971684010 @default.
- W2947609966 hasRelatedWork W3036545402 @default.
- W2947609966 hasRelatedWork W3165348016 @default.
- W2947609966 hasRelatedWork W2431254731 @default.
- W2947609966 isParatext "false" @default.
- W2947609966 isRetracted "false" @default.
- W2947609966 magId "2947609966" @default.
- W2947609966 workType "article" @default.