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• W2947646948 abstract "Abstract Diverse benzylidene indanones and their derivatives were synthesized as anticancer agents. Two of the analogues, that is 7 and 22, exhibited significant antiproliferative activity against several human cancer cell lines. Both the compounds possessed antimitotic activity and induced apoptosis in DLD 1 colorectal adenocarcinoma cells through activation of caspase pathways. In cell cycle analysis, both the compounds induced predominantly G2/M phase arrest in DLD 1 cells. Molecular docking studies revealed that compound 7 occupies colchicine binding pocket of β‐tubulin. Both the compounds were safe in acute oral toxicity in rodents. Both the compounds are further being optimized for better efficacy." @default.
• W2947646948 created "2019-06-07" @default.
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• W2947646948 date "2019-07-10" @default.
• W2947646948 modified "2023-10-16" @default.
• W2947646948 title "3‐Arylindanones and related compounds as antiproliferative agents against colorectal cancer" @default.
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• W2947646948 doi "https://doi.org/10.1111/cbdd.13574" @default.
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