Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947648311> ?p ?o ?g. }
- W2947648311 endingPage "1241" @default.
- W2947648311 startingPage "1241" @default.
- W2947648311 abstract "Maternal overnutrition during pregnancy leads to metabolic alterations, including obesity, hyperphagia, and inflammation in the offspring. Nutritional priming of central inflammation and its role in ghrelin sensitivity during fed and fasted states have not been analyzed. The current study aims to identify the effect of maternal programming on microglia activation and ghrelin-induced activation of hypothalamic neurons leading to food intake response. We employed a nutritional programming model exposing female Wistar rats to a cafeteria diet (CAF) from pre-pregnancy to weaning. Food intake in male offspring was determined daily after fasting and subcutaneous injection of ghrelin. Hypothalamic ghrelin sensitivity and microglia activation was evaluated using immunodetection for Iba-1 and c-Fos markers, and Western blot for TBK1 signaling. Release of TNF-alpha, IL-6, and IL-1β after stimulation with palmitic, oleic, linoleic acid, or C6 ceramide in primary microglia culture were quantified using ELISA. We found that programmed offspring by CAF diet exhibits overfeeding after fasting and peripheral ghrelin administration, which correlates with an increase in the hypothalamic Iba-1 microglia marker and c-Fos cell activation. Additionally, in contrast to oleic, linoleic, or C6 ceramide stimulation in primary microglia culture, stimulation with palmitic acid for 24 h promotes TNF-alpha, IL-6, and IL-1β release and TBK1 activation. Notably, intracerebroventricular (i.c.v.) palmitic acid or LPS inoculation for five days promotes daily increase in food intake and food consumption after ghrelin administration. Finally, we found that i.c.v. palmitic acid substantially activates hypothalamic Iba-1 microglia marker and c-Fos. Together, our results suggest that maternal nutritional programing primes ghrelin sensitivity and microglia activation, which potentially might mirror hypothalamic administration of the saturated palmitic acid." @default.
- W2947648311 created "2019-06-07" @default.
- W2947648311 creator A5003168704 @default.
- W2947648311 creator A5007483627 @default.
- W2947648311 creator A5013921221 @default.
- W2947648311 creator A5021670186 @default.
- W2947648311 creator A5027760691 @default.
- W2947648311 creator A5033375412 @default.
- W2947648311 creator A5034365321 @default.
- W2947648311 date "2019-05-31" @default.
- W2947648311 modified "2023-09-29" @default.
- W2947648311 title "Priming of Hypothalamic Ghrelin Signaling and Microglia Activation Exacerbate Feeding in Rats’ Offspring Following Maternal Overnutrition" @default.
- W2947648311 cites W1616806865 @default.
- W2947648311 cites W1966261651 @default.
- W2947648311 cites W1982703569 @default.
- W2947648311 cites W1984316920 @default.
- W2947648311 cites W2014366175 @default.
- W2947648311 cites W2015760895 @default.
- W2947648311 cites W2019037192 @default.
- W2947648311 cites W2019654241 @default.
- W2947648311 cites W2025131475 @default.
- W2947648311 cites W2027108665 @default.
- W2947648311 cites W2033218360 @default.
- W2947648311 cites W2042364545 @default.
- W2947648311 cites W2063088317 @default.
- W2947648311 cites W2067875627 @default.
- W2947648311 cites W2071470362 @default.
- W2947648311 cites W2074599889 @default.
- W2947648311 cites W2084588595 @default.
- W2947648311 cites W2087554494 @default.
- W2947648311 cites W2132698409 @default.
- W2947648311 cites W2154696002 @default.
- W2947648311 cites W2164315700 @default.
- W2947648311 cites W2315759998 @default.
- W2947648311 cites W2357991904 @default.
- W2947648311 cites W2471119131 @default.
- W2947648311 cites W2473348504 @default.
- W2947648311 cites W2491530692 @default.
- W2947648311 cites W2516167721 @default.
- W2947648311 cites W2517391105 @default.
- W2947648311 cites W2522808902 @default.
- W2947648311 cites W2593628666 @default.
- W2947648311 cites W2598664670 @default.
- W2947648311 cites W2598745770 @default.
- W2947648311 cites W2610578393 @default.
- W2947648311 cites W2727793071 @default.
- W2947648311 cites W2740297777 @default.
- W2947648311 cites W2746944596 @default.
- W2947648311 cites W2757331636 @default.
- W2947648311 cites W2773659498 @default.
- W2947648311 cites W2779717235 @default.
- W2947648311 cites W2794942947 @default.
- W2947648311 cites W2801670879 @default.
- W2947648311 cites W2805854894 @default.
- W2947648311 cites W2885043330 @default.
- W2947648311 cites W2905373271 @default.
- W2947648311 cites W2919800113 @default.
- W2947648311 cites W2922123514 @default.
- W2947648311 cites W2922254948 @default.
- W2947648311 doi "https://doi.org/10.3390/nu11061241" @default.
- W2947648311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6627862" @default.
- W2947648311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31159189" @default.
- W2947648311 hasPublicationYear "2019" @default.
- W2947648311 type Work @default.
- W2947648311 sameAs 2947648311 @default.
- W2947648311 citedByCount "20" @default.
- W2947648311 countsByYear W29476483112020 @default.
- W2947648311 countsByYear W29476483112021 @default.
- W2947648311 countsByYear W29476483112022 @default.
- W2947648311 countsByYear W29476483112023 @default.
- W2947648311 crossrefType "journal-article" @default.
- W2947648311 hasAuthorship W2947648311A5003168704 @default.
- W2947648311 hasAuthorship W2947648311A5007483627 @default.
- W2947648311 hasAuthorship W2947648311A5013921221 @default.
- W2947648311 hasAuthorship W2947648311A5021670186 @default.
- W2947648311 hasAuthorship W2947648311A5027760691 @default.
- W2947648311 hasAuthorship W2947648311A5033375412 @default.
- W2947648311 hasAuthorship W2947648311A5034365321 @default.
- W2947648311 hasBestOaLocation W29476483111 @default.
- W2947648311 hasConcept C112672928 @default.
- W2947648311 hasConcept C126322002 @default.
- W2947648311 hasConcept C134018914 @default.
- W2947648311 hasConcept C24998067 @default.
- W2947648311 hasConcept C2776914184 @default.
- W2947648311 hasConcept C2778302649 @default.
- W2947648311 hasConcept C2779234561 @default.
- W2947648311 hasConcept C2779357093 @default.
- W2947648311 hasConcept C2779830541 @default.
- W2947648311 hasConcept C2779936771 @default.
- W2947648311 hasConcept C511355011 @default.
- W2947648311 hasConcept C543025807 @default.
- W2947648311 hasConcept C54355233 @default.
- W2947648311 hasConcept C55493867 @default.
- W2947648311 hasConcept C71315377 @default.
- W2947648311 hasConcept C71924100 @default.
- W2947648311 hasConcept C86803240 @default.
- W2947648311 hasConceptScore W2947648311C112672928 @default.
- W2947648311 hasConceptScore W2947648311C126322002 @default.