FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947653669> ?p ?o ?g. }

• W2947653669 abstract "The therapeutic use of Helleborus niger L. is manifold due to its specific phytochemical composition. Two compound groups, the ranunculin derivates including protoanemonin and the steroidal saponins, are also associated with toxicity (genotoxicity, disintegration of membrane structures). Therefore, in vitro investigations were performed on safety aspects of a Helleborus niger aqueous fermented extract (HNE). In addition its therapeutic potential against various cancer cell lines was assessed to gain insight into the respective mechanisms of action.To evaluate the safe use of HNE, Ames and hemolytic tests were carried out. Two angiogenesis assays in 2D and 3D design were conducted to assess the anti-angiogenetic potential, for which human umbilical vein endothelial cells (HUVEC) were chosen. A panel of tumor cell lines was used in 2D and 3D proliferation assays as well in the migration- and invasion-assay. All investigations were performed with HNE compared to reference substances. The 2D proliferation assay was additionally performed with isolated compounds of HNE (characteristic steroidal saponins).HNE did not exhibit any genotoxic potential. Concentrations up to 10 μl/ml were classified as non-hemolytic. HNE exerted anti-angiogenetic effects in HUVEC and anti-proliferative effects in five cancer cell lines, whereas hellebosaponin A and D as well macranthosid I did not show comparable effects neither singly nor in combination. Due to the inherent instability of protoanemonin in isolated form, parallel investigations with protoanemonin could not be performed. HNE (600-1000 μg/ml) inhibited the migration of certain cancer cells by > 80% such as Caki-2, DLD-1 and SK-N-SH.HNE exhibit neither genotoxic nor hemolytic potential. The present investigations verify the anti-angiogenetic effects on HUVEC, the anti-proliferative effects and migration-inhibiting properties on tumor cells. The lower effect of the relevant steroidal saponins compared to the whole extract underlines the fact that the latter is more effective than a blend of isolated pharmacologically active components." @default.
• W2947653669 created "2019-06-07" @default.
• W2947653669 creator A5040461752 @default.
• W2947653669 creator A5058862007 @default.
• W2947653669 creator A5061355050 @default.
• W2947653669 creator A5073177757 @default.
• W2947653669 creator A5075179204 @default.
• W2947653669 creator A5077116146 @default.
• W2947653669 date "2019-05-21" @default.
• W2947653669 modified "2023-10-16" @default.
• W2947653669 title "Preclinical evaluation of safety and potential of black hellebore extracts for cancer treatment" @default.
• W2947653669 cites W129251135 @default.
• W2947653669 cites W1835091344 @default.
• W2947653669 cites W1978139448 @default.
• W2947653669 cites W2004678494 @default.
• W2947653669 cites W2009240587 @default.
• W2947653669 cites W2010846595 @default.
• W2947653669 cites W2011520668 @default.
• W2947653669 cites W2013315122 @default.
• W2947653669 cites W2032058270 @default.
• W2947653669 cites W2034279850 @default.
• W2947653669 cites W2036281366 @default.
• W2947653669 cites W2048695976 @default.
• W2947653669 cites W2051324611 @default.
• W2947653669 cites W2054728198 @default.
• W2947653669 cites W2072098167 @default.
• W2947653669 cites W2072366291 @default.
• W2947653669 cites W2091840811 @default.
• W2947653669 cites W2098533150 @default.
• W2947653669 cites W2121129114 @default.
• W2947653669 cites W2168215545 @default.
• W2947653669 cites W2499058990 @default.
• W2947653669 doi "https://doi.org/10.1186/s12906-019-2517-5" @default.
• W2947653669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6528284" @default.
• W2947653669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31113420" @default.
• W2947653669 hasPublicationYear "2019" @default.
• W2947653669 type Work @default.
• W2947653669 sameAs 2947653669 @default.
• W2947653669 citedByCount "10" @default.
• W2947653669 countsByYear W29476536692020 @default.
• W2947653669 countsByYear W29476536692022 @default.
• W2947653669 countsByYear W29476536692023 @default.
• W2947653669 crossrefType "journal-article" @default.
• W2947653669 hasAuthorship W2947653669A5040461752 @default.
• W2947653669 hasAuthorship W2947653669A5058862007 @default.
• W2947653669 hasAuthorship W2947653669A5061355050 @default.
• W2947653669 hasAuthorship W2947653669A5073177757 @default.
• W2947653669 hasAuthorship W2947653669A5075179204 @default.
• W2947653669 hasAuthorship W2947653669A5077116146 @default.
• W2947653669 hasBestOaLocation W29476536691 @default.
• W2947653669 hasConcept C121608353 @default.
• W2947653669 hasConcept C126322002 @default.
• W2947653669 hasConcept C185592680 @default.
• W2947653669 hasConcept C195475562 @default.
• W2947653669 hasConcept C202751555 @default.
• W2947653669 hasConcept C2777411675 @default.
• W2947653669 hasConcept C2778959862 @default.
• W2947653669 hasConcept C2780394083 @default.
• W2947653669 hasConcept C29730261 @default.
• W2947653669 hasConcept C502942594 @default.
• W2947653669 hasConcept C54355233 @default.
• W2947653669 hasConcept C55493867 @default.
• W2947653669 hasConcept C556039675 @default.
• W2947653669 hasConcept C71924100 @default.
• W2947653669 hasConcept C81885089 @default.
• W2947653669 hasConcept C86803240 @default.
• W2947653669 hasConcept C96232424 @default.
• W2947653669 hasConcept C98274493 @default.
• W2947653669 hasConceptScore W2947653669C121608353 @default.
• W2947653669 hasConceptScore W2947653669C126322002 @default.
• W2947653669 hasConceptScore W2947653669C185592680 @default.
• W2947653669 hasConceptScore W2947653669C195475562 @default.
• W2947653669 hasConceptScore W2947653669C202751555 @default.
• W2947653669 hasConceptScore W2947653669C2777411675 @default.
• W2947653669 hasConceptScore W2947653669C2778959862 @default.
• W2947653669 hasConceptScore W2947653669C2780394083 @default.
• W2947653669 hasConceptScore W2947653669C29730261 @default.
• W2947653669 hasConceptScore W2947653669C502942594 @default.
• W2947653669 hasConceptScore W2947653669C54355233 @default.
• W2947653669 hasConceptScore W2947653669C55493867 @default.
• W2947653669 hasConceptScore W2947653669C556039675 @default.
• W2947653669 hasConceptScore W2947653669C71924100 @default.
• W2947653669 hasConceptScore W2947653669C81885089 @default.
• W2947653669 hasConceptScore W2947653669C86803240 @default.
• W2947653669 hasConceptScore W2947653669C96232424 @default.
• W2947653669 hasConceptScore W2947653669C98274493 @default.
• W2947653669 hasIssue "1" @default.
• W2947653669 hasLocation W29476536691 @default.
• W2947653669 hasLocation W29476536692 @default.
• W2947653669 hasLocation W29476536693 @default.
• W2947653669 hasLocation W29476536694 @default.
• W2947653669 hasOpenAccess W2947653669 @default.
• W2947653669 hasPrimaryLocation W29476536691 @default.
• W2947653669 hasRelatedWork W2091355127 @default.
• W2947653669 hasRelatedWork W2354125101 @default.
• W2947653669 hasRelatedWork W2357503743 @default.
• W2947653669 hasRelatedWork W2387407221 @default.
• W2947653669 hasRelatedWork W2604710955 @default.
• W2947653669 hasRelatedWork W3185299333 @default.
• W2947653669 hasRelatedWork W3207677898 @default.

• next