Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947662005> ?p ?o ?g. }
- W2947662005 endingPage "12320" @default.
- W2947662005 startingPage "12311" @default.
- W2947662005 abstract "Significance FBXW7 is a typical tumor suppressor by targeting many oncoproteins for ubiquitylation and degradation, whereas LSD1 has oncogenic activity. Whether and how FBXW7 and LSD1 interact, with what biological consequence, are unknown. Here, we report that LSD1 is a pseudosubstrate of FBXW7. Upon binding with FBXW7, LSD1, instead of being degraded, disrupts FBXW7 dimerization and promotes FBXW7 self-ubiquitylation and degradation via proteasome and lysosomal pathways in a manner independent of its demethylase activity. As such, LSD1 abrogates biological functions of FBXW7 in growth suppression, nonhomologous end-joining repair, and radioprotection. Our study reveals a novel oncogenic mechanism of LSD1 by targeting FBXW7 and provides a sound strategy to reactivate FBXW7 by PROTAC-based LSD1 degradation in human cancers harboring wild-type FBXW7 with overexpressed LSD1." @default.
- W2947662005 created "2019-06-07" @default.
- W2947662005 creator A5015917699 @default.
- W2947662005 creator A5017521861 @default.
- W2947662005 creator A5026852368 @default.
- W2947662005 creator A5028825825 @default.
- W2947662005 creator A5029815331 @default.
- W2947662005 creator A5039837606 @default.
- W2947662005 creator A5051826848 @default.
- W2947662005 creator A5075969066 @default.
- W2947662005 date "2019-05-31" @default.
- W2947662005 modified "2023-10-12" @default.
- W2947662005 title "LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity" @default.
- W2947662005 cites W1538085254 @default.
- W2947662005 cites W1603797292 @default.
- W2947662005 cites W1638088449 @default.
- W2947662005 cites W1889748947 @default.
- W2947662005 cites W1965027943 @default.
- W2947662005 cites W1965205650 @default.
- W2947662005 cites W1967986514 @default.
- W2947662005 cites W1970430170 @default.
- W2947662005 cites W1974449499 @default.
- W2947662005 cites W1977403211 @default.
- W2947662005 cites W1980581641 @default.
- W2947662005 cites W1988876415 @default.
- W2947662005 cites W1992659717 @default.
- W2947662005 cites W2013171128 @default.
- W2947662005 cites W2022675211 @default.
- W2947662005 cites W2033160470 @default.
- W2947662005 cites W2034156554 @default.
- W2947662005 cites W2034375388 @default.
- W2947662005 cites W2034882046 @default.
- W2947662005 cites W2047746661 @default.
- W2947662005 cites W2050723217 @default.
- W2947662005 cites W2055874017 @default.
- W2947662005 cites W2059380840 @default.
- W2947662005 cites W2063104773 @default.
- W2947662005 cites W2068945536 @default.
- W2947662005 cites W2071152209 @default.
- W2947662005 cites W2072677280 @default.
- W2947662005 cites W2086677653 @default.
- W2947662005 cites W2097164847 @default.
- W2947662005 cites W2104198050 @default.
- W2947662005 cites W2121266842 @default.
- W2947662005 cites W2129389521 @default.
- W2947662005 cites W2135921962 @default.
- W2947662005 cites W2142183096 @default.
- W2947662005 cites W2144762247 @default.
- W2947662005 cites W2148383862 @default.
- W2947662005 cites W2225308925 @default.
- W2947662005 cites W2323996569 @default.
- W2947662005 cites W2349288993 @default.
- W2947662005 cites W2535437812 @default.
- W2947662005 cites W2619266720 @default.
- W2947662005 cites W2736147637 @default.
- W2947662005 cites W2738161330 @default.
- W2947662005 cites W2761393041 @default.
- W2947662005 cites W2791963264 @default.
- W2947662005 cites W2792290561 @default.
- W2947662005 cites W2793379439 @default.
- W2947662005 cites W2795906582 @default.
- W2947662005 cites W2809237949 @default.
- W2947662005 cites W4212766227 @default.
- W2947662005 doi "https://doi.org/10.1073/pnas.1902012116" @default.
- W2947662005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6589684" @default.
- W2947662005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31152129" @default.
- W2947662005 hasPublicationYear "2019" @default.
- W2947662005 type Work @default.
- W2947662005 sameAs 2947662005 @default.
- W2947662005 citedByCount "48" @default.
- W2947662005 countsByYear W29476620052019 @default.
- W2947662005 countsByYear W29476620052020 @default.
- W2947662005 countsByYear W29476620052021 @default.
- W2947662005 countsByYear W29476620052022 @default.
- W2947662005 countsByYear W29476620052023 @default.
- W2947662005 crossrefType "journal-article" @default.
- W2947662005 hasAuthorship W2947662005A5015917699 @default.
- W2947662005 hasAuthorship W2947662005A5017521861 @default.
- W2947662005 hasAuthorship W2947662005A5026852368 @default.
- W2947662005 hasAuthorship W2947662005A5028825825 @default.
- W2947662005 hasAuthorship W2947662005A5029815331 @default.
- W2947662005 hasAuthorship W2947662005A5039837606 @default.
- W2947662005 hasAuthorship W2947662005A5051826848 @default.
- W2947662005 hasAuthorship W2947662005A5075969066 @default.
- W2947662005 hasBestOaLocation W29476620051 @default.
- W2947662005 hasConcept C104317684 @default.
- W2947662005 hasConcept C134459356 @default.
- W2947662005 hasConcept C179185449 @default.
- W2947662005 hasConcept C185592680 @default.
- W2947662005 hasConcept C25602115 @default.
- W2947662005 hasConcept C27740335 @default.
- W2947662005 hasConcept C2781364455 @default.
- W2947662005 hasConcept C552990157 @default.
- W2947662005 hasConcept C55493867 @default.
- W2947662005 hasConcept C64927066 @default.
- W2947662005 hasConcept C86803240 @default.
- W2947662005 hasConcept C95444343 @default.
- W2947662005 hasConceptScore W2947662005C104317684 @default.