Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947669063> ?p ?o ?g. }
- W2947669063 endingPage "6466" @default.
- W2947669063 startingPage "6457" @default.
- W2947669063 abstract "All-hydrocarbon, i, i+7 stapled peptide inhibitors of the p53-Mdm2 interaction have emerged as promising new leads for cancer therapy. Typical chemical synthesis via olefin metathesis results in the formation of both E- and Z-isomers, an observation that is rarely disclosed but may be of importance in targeting PPI. In this study, we evaluated the effect of staple geometry on the biological activity of five p53-reactivating peptides. We also present strategies for the modulation of the E/Z ratio and attainment of the hydrogenated adduct through repurposing of the metathesis catalyst." @default.
- W2947669063 created "2019-06-07" @default.
- W2947669063 creator A5014585040 @default.
- W2947669063 creator A5017829338 @default.
- W2947669063 creator A5018030366 @default.
- W2947669063 creator A5030177681 @default.
- W2947669063 creator A5035752778 @default.
- W2947669063 creator A5045760818 @default.
- W2947669063 creator A5057065974 @default.
- W2947669063 creator A5069728112 @default.
- W2947669063 creator A5070284125 @default.
- W2947669063 creator A5074799611 @default.
- W2947669063 creator A5075834923 @default.
- W2947669063 creator A5078886672 @default.
- W2947669063 creator A5084000993 @default.
- W2947669063 date "2019-01-01" @default.
- W2947669063 modified "2023-10-18" @default.
- W2947669063 title "Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles" @default.
- W2947669063 cites W1530703035 @default.
- W2947669063 cites W1965819962 @default.
- W2947669063 cites W1966291173 @default.
- W2947669063 cites W1967962288 @default.
- W2947669063 cites W1970106287 @default.
- W2947669063 cites W1976159407 @default.
- W2947669063 cites W1978067561 @default.
- W2947669063 cites W1978999164 @default.
- W2947669063 cites W1984294834 @default.
- W2947669063 cites W1990846813 @default.
- W2947669063 cites W1992947288 @default.
- W2947669063 cites W1995174752 @default.
- W2947669063 cites W1996701599 @default.
- W2947669063 cites W1998233841 @default.
- W2947669063 cites W2004273407 @default.
- W2947669063 cites W2020789636 @default.
- W2947669063 cites W2023018411 @default.
- W2947669063 cites W2025487526 @default.
- W2947669063 cites W2033716878 @default.
- W2947669063 cites W2040576705 @default.
- W2947669063 cites W2042061022 @default.
- W2947669063 cites W2043831235 @default.
- W2947669063 cites W2043935388 @default.
- W2947669063 cites W2045525952 @default.
- W2947669063 cites W2060158924 @default.
- W2947669063 cites W2062552623 @default.
- W2947669063 cites W2071586142 @default.
- W2947669063 cites W2072435450 @default.
- W2947669063 cites W2073857335 @default.
- W2947669063 cites W2076266831 @default.
- W2947669063 cites W2084156461 @default.
- W2947669063 cites W2084214674 @default.
- W2947669063 cites W2087428925 @default.
- W2947669063 cites W2089576018 @default.
- W2947669063 cites W2093775600 @default.
- W2947669063 cites W2094130001 @default.
- W2947669063 cites W2094233225 @default.
- W2947669063 cites W2097888801 @default.
- W2947669063 cites W2097933346 @default.
- W2947669063 cites W2099404272 @default.
- W2947669063 cites W2107537090 @default.
- W2947669063 cites W2110969535 @default.
- W2947669063 cites W2129826523 @default.
- W2947669063 cites W2138886211 @default.
- W2947669063 cites W2140249415 @default.
- W2947669063 cites W2154799239 @default.
- W2947669063 cites W2167279371 @default.
- W2947669063 cites W2263462535 @default.
- W2947669063 cites W2297151034 @default.
- W2947669063 cites W2321192115 @default.
- W2947669063 cites W2330036318 @default.
- W2947669063 cites W2339587248 @default.
- W2947669063 cites W2471234077 @default.
- W2947669063 cites W2473529372 @default.
- W2947669063 cites W2516010850 @default.
- W2947669063 cites W2531723709 @default.
- W2947669063 cites W2588794854 @default.
- W2947669063 cites W2597626608 @default.
- W2947669063 cites W2599690337 @default.
- W2947669063 cites W2604307388 @default.
- W2947669063 cites W2611126472 @default.
- W2947669063 cites W2619215515 @default.
- W2947669063 cites W2666136463 @default.
- W2947669063 cites W2725173040 @default.
- W2947669063 cites W2772475198 @default.
- W2947669063 cites W2789119630 @default.
- W2947669063 cites W2789194621 @default.
- W2947669063 cites W2794188705 @default.
- W2947669063 cites W2953343485 @default.
- W2947669063 cites W4253340866 @default.
- W2947669063 doi "https://doi.org/10.1039/c9sc01456j" @default.
- W2947669063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6610352" @default.
- W2947669063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31316744" @default.
- W2947669063 hasPublicationYear "2019" @default.
- W2947669063 type Work @default.
- W2947669063 sameAs 2947669063 @default.
- W2947669063 citedByCount "21" @default.
- W2947669063 countsByYear W29476690632019 @default.
- W2947669063 countsByYear W29476690632020 @default.
- W2947669063 countsByYear W29476690632021 @default.