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- W2947671035 abstract "iNKT cells recognize CD1d/α-galactosylceramide (α-GalCer) complexes via their invariant TCR receptor and stimulate the immune response. Many α-GalCer analogues have been investigated to interrogate this interaction. Following our previous work related to the modification of the hydrogen bond network between α-GalCer and CD1d, we have now focused our attention on the synthesis of 3-deoxy-3,3-difluoro- and 3,4-dideoxy-3,3,4,4-tetrafluoro-α-GalCer analogues, and studied their ability to stimulate human iNKT cells. In each case, deoxygenation at the indicated positions was accompanied by difluoro introduction in order to evaluate the resulting electronic effect on the stability of the ternary CD1d/Galcer/TCR complex which has been rationalized by modeling study. With deoxy-difluorination at the 3-position, the two epimeric 4-OH analogues were investigated to establish their capacity to compensate for the lack of the hydrogen bond donating group at the 3-position. The 3,4-dideoxytetrafluoro analogue was of interest to highlight the amide NH-bond hydrogen bond properties." @default.
- W2947671035 created "2019-06-07" @default.
- W2947671035 creator A5005347738 @default.
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- W2947671035 creator A5084917982 @default.
- W2947671035 date "2019-09-01" @default.
- W2947671035 modified "2023-10-14" @default.
- W2947671035 title "3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation" @default.
- W2947671035 cites W1483804182 @default.
- W2947671035 cites W1515131015 @default.
- W2947671035 cites W1538172952 @default.
- W2947671035 cites W1542562398 @default.
- W2947671035 cites W1568297835 @default.
- W2947671035 cites W1570336130 @default.
- W2947671035 cites W1683266792 @default.
- W2947671035 cites W1864648105 @default.
- W2947671035 cites W1883217637 @default.
- W2947671035 cites W1900894033 @default.
- W2947671035 cites W1909971323 @default.
- W2947671035 cites W1913627479 @default.
- W2947671035 cites W1965621413 @default.
- W2947671035 cites W1966204602 @default.
- W2947671035 cites W1966758216 @default.
- W2947671035 cites W1966998421 @default.
- W2947671035 cites W1967219714 @default.
- W2947671035 cites W1967369789 @default.
- W2947671035 cites W1968200099 @default.
- W2947671035 cites W1970133393 @default.
- W2947671035 cites W1971066229 @default.
- W2947671035 cites W1974936220 @default.
- W2947671035 cites W1983401069 @default.
- W2947671035 cites W1988342375 @default.
- W2947671035 cites W1989564452 @default.
- W2947671035 cites W1989626793 @default.
- W2947671035 cites W1990846517 @default.
- W2947671035 cites W1991083242 @default.
- W2947671035 cites W1995529916 @default.
- W2947671035 cites W1997047110 @default.
- W2947671035 cites W1999798503 @default.
- W2947671035 cites W2002167847 @default.
- W2947671035 cites W2003022699 @default.
- W2947671035 cites W2004122281 @default.
- W2947671035 cites W2004687347 @default.
- W2947671035 cites W2008259276 @default.
- W2947671035 cites W2008657122 @default.
- W2947671035 cites W2009735406 @default.
- W2947671035 cites W2012475762 @default.
- W2947671035 cites W2013660817 @default.
- W2947671035 cites W2014433507 @default.
- W2947671035 cites W2016408672 @default.
- W2947671035 cites W2017144939 @default.
- W2947671035 cites W2022678668 @default.
- W2947671035 cites W2025009528 @default.
- W2947671035 cites W2026058426 @default.
- W2947671035 cites W2028221734 @default.
- W2947671035 cites W2033043158 @default.
- W2947671035 cites W2033443495 @default.
- W2947671035 cites W2036601571 @default.
- W2947671035 cites W2037980239 @default.
- W2947671035 cites W2040843705 @default.
- W2947671035 cites W2041838304 @default.
- W2947671035 cites W2042214755 @default.
- W2947671035 cites W2044775413 @default.
- W2947671035 cites W2046085625 @default.
- W2947671035 cites W2048724356 @default.
- W2947671035 cites W2048809368 @default.
- W2947671035 cites W2049521781 @default.
- W2947671035 cites W2049774707 @default.
- W2947671035 cites W2049806716 @default.
- W2947671035 cites W2050481689 @default.
- W2947671035 cites W2050925766 @default.
- W2947671035 cites W2051568453 @default.
- W2947671035 cites W2052054111 @default.
- W2947671035 cites W2054017521 @default.
- W2947671035 cites W2055190933 @default.
- W2947671035 cites W2055413263 @default.
- W2947671035 cites W2056653271 @default.
- W2947671035 cites W2056952692 @default.
- W2947671035 cites W2057263082 @default.
- W2947671035 cites W2057856543 @default.
- W2947671035 cites W2058047032 @default.
- W2947671035 cites W2059313909 @default.
- W2947671035 cites W2062403869 @default.
- W2947671035 cites W2062927527 @default.
- W2947671035 cites W2063498224 @default.
- W2947671035 cites W2063590695 @default.