FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947676873> ?p ?o ?g. }

• W2947676873 endingPage "117" @default.
• W2947676873 startingPage "105" @default.
• W2947676873 abstract "Abstract Peritoneal adhesion occurs frequently after gastrointestinal/gynecological surgery. Tissue repair and regeneration are very important during this process. IL‐22 is an important cytokine that is secreted from immune cells but functions on mesenchymal cells, such as mesothelial cells. The objective of this study was to investigate the roles of IL‐22 and its regulators during adhesion formation. Postsurgical peritoneal drainage fluid from patients and rodent models was examined by enzyme‐linked immunosorbent assay and fluorescence‐activated cell sorting. It was observed that IL‐22 expression in the abdominal cavity was rapidly induced 12 hours after surgery and then slowly decreased to a lower, steady level for up to 7 days after surgery. However, neutralizing IL‐22 at the time point at which the highest level of expression was observed failed to reduce adhesion, but neutralizing IL‐22 at a later time point, i.e., 3 days after surgery, prevented adhesion significantly. The IL‐22 receptor was induced on the mesothelial membrane, and IL‐22BP, an inhibitor of IL‐22, was reduced 3 days after surgery. Furthermore, IFN‐γ was identified to have the ability to induce IL‐22R, and IL‐18, which was induced by the infiltrating macrophages, was found to inhibit IL‐22BP expression both in vivo and in vitro. Together, these data suggest that IL‐22 may promote adhesion formation and that the regulation of IL‐22, IL‐22R, and IL‐22BP may have therapeutic potential to prevent adhesion formation after surgery without disturbing the normal immune process." @default.
• W2947676873 created "2019-06-07" @default.
• W2947676873 creator A5000432967 @default.
• W2947676873 creator A5034796819 @default.
• W2947676873 creator A5037424395 @default.
• W2947676873 creator A5038365435 @default.
• W2947676873 creator A5042612782 @default.
• W2947676873 creator A5055330527 @default.
• W2947676873 creator A5067612393 @default.
• W2947676873 creator A5079375938 @default.
• W2947676873 creator A5090619564 @default.
• W2947676873 creator A5049432301 @default.
• W2947676873 date "2019-06-13" @default.
• W2947676873 modified "2023-10-16" @default.
• W2947676873 title "Regulation and function of IL‐22 in peritoneal adhesion formation after abdominal surgery" @default.
• W2947676873 cites W1488288160 @default.
• W2947676873 cites W1526879038 @default.
• W2947676873 cites W1535831265 @default.
• W2947676873 cites W1548300414 @default.
• W2947676873 cites W1935965867 @default.
• W2947676873 cites W1949972382 @default.
• W2947676873 cites W1964704428 @default.
• W2947676873 cites W1972140301 @default.
• W2947676873 cites W1981299945 @default.
• W2947676873 cites W1983930473 @default.
• W2947676873 cites W1998345830 @default.
• W2947676873 cites W2007206639 @default.
• W2947676873 cites W2008751364 @default.
• W2947676873 cites W2020275335 @default.
• W2947676873 cites W2027997166 @default.
• W2947676873 cites W2035510495 @default.
• W2947676873 cites W2038131331 @default.
• W2947676873 cites W2044264133 @default.
• W2947676873 cites W2047284886 @default.
• W2947676873 cites W2055403920 @default.
• W2947676873 cites W2055912677 @default.
• W2947676873 cites W2057302700 @default.
• W2947676873 cites W2063363172 @default.
• W2947676873 cites W2064796928 @default.
• W2947676873 cites W2074865203 @default.
• W2947676873 cites W2080442169 @default.
• W2947676873 cites W2091845172 @default.
• W2947676873 cites W2106464597 @default.
• W2947676873 cites W2107842454 @default.
• W2947676873 cites W2112220475 @default.
• W2947676873 cites W2115510769 @default.
• W2947676873 cites W2124390485 @default.
• W2947676873 cites W2157713142 @default.
• W2947676873 cites W2165377772 @default.
• W2947676873 cites W2166788119 @default.
• W2947676873 cites W2169355315 @default.
• W2947676873 cites W2169378111 @default.
• W2947676873 cites W2517503705 @default.
• W2947676873 cites W2624672837 @default.
• W2947676873 cites W2742936971 @default.
• W2947676873 doi "https://doi.org/10.1111/wrr.12740" @default.
• W2947676873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31148320" @default.
• W2947676873 hasPublicationYear "2019" @default.
• W2947676873 type Work @default.
• W2947676873 sameAs 2947676873 @default.
• W2947676873 citedByCount "7" @default.
• W2947676873 countsByYear W29476768732020 @default.
• W2947676873 countsByYear W29476768732021 @default.
• W2947676873 countsByYear W29476768732022 @default.
• W2947676873 countsByYear W29476768732023 @default.
• W2947676873 crossrefType "journal-article" @default.
• W2947676873 hasAuthorship W2947676873A5000432967 @default.
• W2947676873 hasAuthorship W2947676873A5034796819 @default.
• W2947676873 hasAuthorship W2947676873A5037424395 @default.
• W2947676873 hasAuthorship W2947676873A5038365435 @default.
• W2947676873 hasAuthorship W2947676873A5042612782 @default.
• W2947676873 hasAuthorship W2947676873A5049432301 @default.
• W2947676873 hasAuthorship W2947676873A5055330527 @default.
• W2947676873 hasAuthorship W2947676873A5067612393 @default.
• W2947676873 hasAuthorship W2947676873A5079375938 @default.
• W2947676873 hasAuthorship W2947676873A5090619564 @default.
• W2947676873 hasConcept C141071460 @default.
• W2947676873 hasConcept C142724271 @default.
• W2947676873 hasConcept C16685009 @default.
• W2947676873 hasConcept C178790620 @default.
• W2947676873 hasConcept C185592680 @default.
• W2947676873 hasConcept C203014093 @default.
• W2947676873 hasConcept C2776914184 @default.
• W2947676873 hasConcept C2778536324 @default.
• W2947676873 hasConcept C2778690821 @default.
• W2947676873 hasConcept C2909640154 @default.
• W2947676873 hasConcept C71924100 @default.
• W2947676873 hasConcept C84416704 @default.
• W2947676873 hasConcept C85789140 @default.
• W2947676873 hasConcept C8891405 @default.
• W2947676873 hasConceptScore W2947676873C141071460 @default.
• W2947676873 hasConceptScore W2947676873C142724271 @default.
• W2947676873 hasConceptScore W2947676873C16685009 @default.
• W2947676873 hasConceptScore W2947676873C178790620 @default.
• W2947676873 hasConceptScore W2947676873C185592680 @default.
• W2947676873 hasConceptScore W2947676873C203014093 @default.
• W2947676873 hasConceptScore W2947676873C2776914184 @default.
• W2947676873 hasConceptScore W2947676873C2778536324 @default.

• next