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- W2947677934 abstract "Abstract Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, MiXeR, which quantifies polygenic overlap irrespective of genetic correlation, using GWAS summary statistics. MiXeR results are presented as a Venn diagram of unique and shared polygenic components across traits. At 90% of SNP-heritability explained for each phenotype, MiXeR estimates that 8.3 K variants causally influence schizophrenia and 6.4 K influence bipolar disorder. Among these variants, 6.2 K are shared between the disorders, which have a high genetic correlation. Further, MiXeR uncovers polygenic overlap between schizophrenia and educational attainment. Despite a genetic correlation close to zero, the phenotypes share 8.3 K causal variants, while 2.5 K additional variants influence only educational attainment. By considering the polygenicity, discoverability and heritability of complex phenotypes, MiXeR analysis may improve our understanding of cross-trait genetic architectures." @default.
- W2947677934 created "2019-06-07" @default.
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- W2947677934 date "2019-06-03" @default.
- W2947677934 modified "2023-10-16" @default.
- W2947677934 title "Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation" @default.
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- W2947677934 doi "https://doi.org/10.1038/s41467-019-10310-0" @default.
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