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- W2947679675 abstract "Purpose We hypothesized that nonsteroidal antiinflammatory drugs decrease the plasma fentanyl concentration required to produce immobility in 50% of patients in response to skin incision (Cp50incision) compared with placebo under target-controlled infusion (TCI) propofol anesthesia. Methods Sixty-two unpremedicated patients scheduled to undergo gynecologic laparoscopy were randomly assigned to receive placebo (control group) or flurbiprofen axetil 1m gkg -1 (flurbiprofen group) preoperatively. General anesthesia was induced with fentanyl and propofol, and intubation was performed after succinylcholine 1 mgkg -1 . Propofol was administered via a target-controlled infusion (TCI) system (Diprifusor TM ) set at an effect-site concentration of 5 lgmL -1 . Fentanyl was given by a TCI system using the STANPUMP software (Schafer model). The concentration for the first patient was set at 3n gmL -1 and modified in each group according to the updown method. Skin incision was performed after more than ten minutes equilibration time. Serum fentanyl concentration, bispectral index (BIS), and hemodynamic parameters were measured two minutes before and after skin incision. The Cp50incision of fentanyl was derived from the mean of the crossovers (i.e., the serum fentanyl concentrations of successive participants who responded and those who did not or vice versa). Results Ten and 11 independent crossover pairs were collected in the control and flurbiprofen groups, respectively, representing 42 of 62 enrolled patients. The mean (SD) fentanyl Cp50incision was less in the flurbiprofen group [0.84 (0.63) ngmL -1 ] than in the control group [1.65 (1.15) ngmL -1 ]; P = 0.007; however, there were no" @default.
- W2947679675 created "2019-06-07" @default.
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- W2947679675 date "2013-01-01" @default.
- W2947679675 modified "2023-09-24" @default.
- W2947679675 title "The fentanyl concentration required for immobility under propofol anesthesia is reduced by pre-treatment with flurbiprofen axetil La concentration de fentanyl necessaire al'immobiliteau cours d'une anesthesie au propofol est diminuee par un pretraitement avec du flurbiprofene axetil" @default.
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