FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947684829> ?p ?o ?g. }

• W2947684829 abstract "e15672 Background: Rare tumors, such as cholangiocarcinoma (CC), have no established treatment protocols, forcing clinicians to select therapies based on educated guesses or small case series. Genomic tumor analyses fail to identify options for most patients. Here, we show the feasibility of using a high-throughput functional assay to test targeted drug libraries on individual patient-derived tumor organoids from CC to yield experimentally-validated therapeutic options. Methods: Three consecutive patients with CC who were undergoing a standard of care biopsy or resection were enrolled in an IRB-approved study. Patient characteristics, demographics, tumor pathology, including Next Generation Sequencing (NGS) data and organoid-derived drug recommendations are shown in the Table. Specimen (~ 200 mg of tumor) was shipped on ice overnight to SEngine Precision Medicine for tumor-derived organoid culture and sensitivity analysis. Organoids were evaluated using a multi-dose response to each drug in a library of 120 FDA-approved and investigational drugs and compared those responses to all prior patients. This established both functional sensitivity and the uniqueness of each patient’s response. Results: We tested operational logistics, tumor growth rates, and chemosensitivity reporting timelines. This has allowed us to: 1) operationalize the expansion process, 2) quantify turn-around time, and 3) identify any technical or logistic barriers. All specimens resulted in adequate growth for sensitivity characterization. None of the NGS studies resulted in recommendations for sensitivity to targeted chemotherapy. Conversely, tumor organoid assays rapidly identified selective, personalized drugs. Conclusions: We have shown the feasibility of this approach in CC. Our preliminary results will inform the design of a future prospective clinical trial to establish and validate this method to select personalized cancer treatments for rare malignancies.[Table: see text]" @default.
• W2947684829 created "2019-06-07" @default.
• W2947684829 creator A5018392486 @default.
• W2947684829 creator A5043358245 @default.
• W2947684829 creator A5072279288 @default.
• W2947684829 creator A5076719905 @default.
• W2947684829 creator A5086661655 @default.
• W2947684829 date "2019-05-20" @default.
• W2947684829 modified "2023-09-27" @default.
• W2947684829 title "Functional personalized oncology to determine drug sensitivity in cholangiocarcinoma." @default.
• W2947684829 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.e15672" @default.
• W2947684829 hasPublicationYear "2019" @default.
• W2947684829 type Work @default.
• W2947684829 sameAs 2947684829 @default.
• W2947684829 citedByCount "1" @default.
• W2947684829 countsByYear W29476848292020 @default.
• W2947684829 crossrefType "journal-article" @default.
• W2947684829 hasAuthorship W2947684829A5018392486 @default.
• W2947684829 hasAuthorship W2947684829A5043358245 @default.
• W2947684829 hasAuthorship W2947684829A5072279288 @default.
• W2947684829 hasAuthorship W2947684829A5076719905 @default.
• W2947684829 hasAuthorship W2947684829A5086661655 @default.
• W2947684829 hasConcept C121608353 @default.
• W2947684829 hasConcept C126322002 @default.
• W2947684829 hasConcept C143998085 @default.
• W2947684829 hasConcept C2776598537 @default.
• W2947684829 hasConcept C2780035454 @default.
• W2947684829 hasConcept C3020497934 @default.
• W2947684829 hasConcept C32220436 @default.
• W2947684829 hasConcept C60644358 @default.
• W2947684829 hasConcept C71924100 @default.
• W2947684829 hasConcept C86803240 @default.
• W2947684829 hasConcept C98274493 @default.
• W2947684829 hasConceptScore W2947684829C121608353 @default.
• W2947684829 hasConceptScore W2947684829C126322002 @default.
• W2947684829 hasConceptScore W2947684829C143998085 @default.
• W2947684829 hasConceptScore W2947684829C2776598537 @default.
• W2947684829 hasConceptScore W2947684829C2780035454 @default.
• W2947684829 hasConceptScore W2947684829C3020497934 @default.
• W2947684829 hasConceptScore W2947684829C32220436 @default.
• W2947684829 hasConceptScore W2947684829C60644358 @default.
• W2947684829 hasConceptScore W2947684829C71924100 @default.
• W2947684829 hasConceptScore W2947684829C86803240 @default.
• W2947684829 hasConceptScore W2947684829C98274493 @default.
• W2947684829 hasLocation W29476848291 @default.
• W2947684829 hasOpenAccess W2947684829 @default.
• W2947684829 hasPrimaryLocation W29476848291 @default.
• W2947684829 isParatext "false" @default.
• W2947684829 isRetracted "false" @default.
• W2947684829 magId "2947684829" @default.
• W2947684829 workType "article" @default.