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- W2947694570 startingPage "53" @default.
- W2947694570 abstract "Primary Sjogren’s syndrome (pSS) is a systemic autoimmune disease characterized by sicca symptoms and a broad variety of systemic clinical manifestations. Indeed, even though keratoconjunctivitis sicca, resulting from the involvement of lacrimal glands, and xerostomia, resulting from the involvement of salivary glands, are usually prominent, pSS presents as a multifaceted and systemic condition with a broad variety of clinical manifestations. The spectrum of pSS extends from an organ-specific autoimmune disorder (referred to as an autoimmune exocrinopathy) to a systemic process and in addition to an increased risk of non-Hodgkin’s lymphoma. More than 50 years ago, genetic involvement was suggested in the etiology of pSS. The idea that genetic and epigenetic factors contribute to the etiology of systemic autoimmune diseases such as pSS is supported by familial autoimmunity and poly-autoimmunity. Most of the genes associated with susceptibility to pSS have been identified because the proteins involved have been previously associated with the pathogenesis of pSS or because the genes had already been associated with another autoimmune disease such as SLE or RA. Consequently, in this chapter, we will first focus on the immunopathology of pSS in order to better understand the genetic and epigenetic alterations described in the disease. The last section will be dedicated to genetic alterations in pSS related to lymphoma." @default.
- W2947694570 created "2019-06-07" @default.
- W2947694570 creator A5005609974 @default.
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- W2947694570 creator A5037571441 @default.
- W2947694570 creator A5077191778 @default.
- W2947694570 creator A5087088946 @default.
- W2947694570 date "2019-01-01" @default.
- W2947694570 modified "2023-10-16" @default.
- W2947694570 title "Sjögren’s Syndrome" @default.
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