FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947704836> ?p ?o ?g. }

• W2947704836 abstract "A recent meta-analysis revealed PAX6 as a risk gene for myopia. There is a link between PAX6 and HOXA9. Furthermore, HOXA9 has been reported to activate TGF-β that is a risk factor for myopia. We speculate HOXA9 may participate in myopia development.The Singapore GUSTO birth cohort provides data on children's cycloplegic refraction measured at age of 3 years and their methylation profile based on the umbilical cord DNA. The HOXA9 expression levels were measured in the eyes of mono-ocular form deprivation myopia in mice. The plasmid with the mouse HOXA9 cDNA was constructed and then transfected to mouse primary retinal pigment epithelial (RPE) cells. The expression levels of myopia-related genes and cell proliferation were measured in the HOXA9-overexpressed RPE cells.A total of 519 children had data on methylation profile and cycloplegic refraction. The mean spherical equivalent refraction (SE) was 0.90D. Among 8 SE outliers (worse than -2D), 7 children had HOXA9 hypomethylation. The HOXA9 levels in the retina of myopic eyes was 2.65-fold (p = 0.029; paired t-test) higher than the uncovered fellow eyes. When HOXA9 was over-expressed in the RPE cells, TGF-β, MMP2, FGF2 and IGF1R expression levels were dose-dependently increased by HOXA9. However, over-expression of HOXA9 had no significant influence on IGF1 or HGF expression. In addition, HOXA9 also increased RPE proliferation.Based on the human, animal and cellular data, the transcription factor HOXA9 may promote the expression of pro-myopia genes and RPE proliferation, which eventually contribute to myopia development." @default.
• W2947704836 created "2019-06-07" @default.
• W2947704836 creator A5006597525 @default.
• W2947704836 creator A5006987172 @default.
• W2947704836 creator A5024524978 @default.
• W2947704836 creator A5038427672 @default.
• W2947704836 creator A5052418430 @default.
• W2947704836 creator A5064124202 @default.
• W2947704836 creator A5067500993 @default.
• W2947704836 creator A5080697479 @default.
• W2947704836 date "2019-01-23" @default.
• W2947704836 modified "2023-10-03" @default.
• W2947704836 title "HOXA9 is a novel myopia risk gene" @default.
• W2947704836 cites W1503694680 @default.
• W2947704836 cites W1553571959 @default.
• W2947704836 cites W1833113601 @default.
• W2947704836 cites W1964861376 @default.
• W2947704836 cites W1968086918 @default.
• W2947704836 cites W1973207504 @default.
• W2947704836 cites W1975528145 @default.
• W2947704836 cites W1980910880 @default.
• W2947704836 cites W1983307705 @default.
• W2947704836 cites W1987217999 @default.
• W2947704836 cites W1988224215 @default.
• W2947704836 cites W1997782721 @default.
• W2947704836 cites W2005000389 @default.
• W2947704836 cites W2023808179 @default.
• W2947704836 cites W2046600562 @default.
• W2947704836 cites W2047790147 @default.
• W2947704836 cites W2049898378 @default.
• W2947704836 cites W2051541780 @default.
• W2947704836 cites W2052218047 @default.
• W2947704836 cites W2057760857 @default.
• W2947704836 cites W2062069215 @default.
• W2947704836 cites W2066501895 @default.
• W2947704836 cites W2070476377 @default.
• W2947704836 cites W2078206948 @default.
• W2947704836 cites W2098909302 @default.
• W2947704836 cites W2105070187 @default.
• W2947704836 cites W2106949596 @default.
• W2947704836 cites W2111274886 @default.
• W2947704836 cites W2124317383 @default.
• W2947704836 cites W2124841522 @default.
• W2947704836 cites W2126663347 @default.
• W2947704836 cites W2136376873 @default.
• W2947704836 cites W2137264803 @default.
• W2947704836 cites W2137560155 @default.
• W2947704836 cites W2153220332 @default.
• W2947704836 cites W2164363851 @default.
• W2947704836 cites W2168579036 @default.
• W2947704836 cites W2170786019 @default.
• W2947704836 cites W2261557252 @default.
• W2947704836 cites W2261730390 @default.
• W2947704836 cites W2322578512 @default.
• W2947704836 cites W2332092756 @default.
• W2947704836 cites W2417745797 @default.
• W2947704836 cites W2560810409 @default.
• W2947704836 cites W2590351842 @default.
• W2947704836 doi "https://doi.org/10.1186/s12886-019-1038-9" @default.
• W2947704836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6343304" @default.
• W2947704836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30674274" @default.
• W2947704836 hasPublicationYear "2019" @default.
• W2947704836 type Work @default.
• W2947704836 sameAs 2947704836 @default.
• W2947704836 citedByCount "8" @default.
• W2947704836 countsByYear W29477048362020 @default.
• W2947704836 countsByYear W29477048362021 @default.
• W2947704836 countsByYear W29477048362022 @default.
• W2947704836 countsByYear W29477048362023 @default.
• W2947704836 crossrefType "journal-article" @default.
• W2947704836 hasAuthorship W2947704836A5006597525 @default.
• W2947704836 hasAuthorship W2947704836A5006987172 @default.
• W2947704836 hasAuthorship W2947704836A5024524978 @default.
• W2947704836 hasAuthorship W2947704836A5038427672 @default.
• W2947704836 hasAuthorship W2947704836A5052418430 @default.
• W2947704836 hasAuthorship W2947704836A5064124202 @default.
• W2947704836 hasAuthorship W2947704836A5067500993 @default.
• W2947704836 hasAuthorship W2947704836A5080697479 @default.
• W2947704836 hasBestOaLocation W29477048361 @default.
• W2947704836 hasConcept C104317684 @default.
• W2947704836 hasConcept C150194340 @default.
• W2947704836 hasConcept C51816534 @default.
• W2947704836 hasConcept C54355233 @default.
• W2947704836 hasConcept C71924100 @default.
• W2947704836 hasConcept C86339819 @default.
• W2947704836 hasConcept C86803240 @default.
• W2947704836 hasConceptScore W2947704836C104317684 @default.
• W2947704836 hasConceptScore W2947704836C150194340 @default.
• W2947704836 hasConceptScore W2947704836C51816534 @default.
• W2947704836 hasConceptScore W2947704836C54355233 @default.
• W2947704836 hasConceptScore W2947704836C71924100 @default.
• W2947704836 hasConceptScore W2947704836C86339819 @default.
• W2947704836 hasConceptScore W2947704836C86803240 @default.
• W2947704836 hasIssue "1" @default.
• W2947704836 hasLocation W29477048361 @default.
• W2947704836 hasLocation W29477048362 @default.
• W2947704836 hasLocation W29477048363 @default.
• W2947704836 hasLocation W29477048364 @default.
• W2947704836 hasOpenAccess W2947704836 @default.
• W2947704836 hasPrimaryLocation W29477048361 @default.

• next