FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947729118> ?p ?o ?g. }

• W2947729118 endingPage "1254" @default.
• W2947729118 startingPage "1248" @default.
• W2947729118 abstract "Abstract Objectives Neuroinflammation, implicated in epilepsy, can be imaged in humans with positron emission tomography (PET) ligands for translocator protein 18 kDa (TSPO). Previous studies in patients with temporal lobe epilepsy and mesial temporal sclerosis found increased [11C]PBR28 uptake ipsilateral to seizure foci. Neocortical foci present more difficult localization problems and more variable underlying pathology. Methods We studied 11 patients with neocortical seizure foci using [11C]PBR28 or [11C] N,N‐diethyl‐2‐(4‐methoxyphenyl)‐5,7‐dimethylpyrazolo[1,5‐a]pyrimidine‐3‐acetamide (DPA) 713, and 31 healthy volunteers. Seizure foci were identified with structural magnetic resonance imaging (MRI) and ictal video–electroencephalography (EEG) monitoring. Six patients had surgical resections; five had focal cortical dysplasia type 2A or B and one microdysgenesis. Brain regions were delineated using FreeSurfer and T1‐weighted MRI. We measured brain radioligand uptake (standardized uptake values [SUVs]) in ipsilateral and contralateral regions, to compare calculated asymmetry indices [AIs; 200% *(ipsilateral − contralateral)/(ipsilateral + contralateral)] between epilepsy patients and controls, as well as absolute [11C]PBR28 binding as the ratio of distribution volume to free fraction ( V T / f P ) in 9 patients (5 high affinity and 4 medium affinity binders) and 11 age‐matched volunteers (5 high‐affinity and 6 medium affinity) who had metabolite‐corrected arterial input functions measured. Results Nine of 11 patients had AIs exceeding control mean 95% confidence intervals in at least one region consistent with the seizure focus. Three of the nine had normal MRI. There was a nonsignificant trend for patients to have higher binding than volunteers both ipsilateral and contralateral to the focus in the group that had absolute binding measured. Significance Our study demonstrates the presence of focal and distributed inflammation in neocortical epilepsy. There may be a role for TSPO PET for evaluation of patients with suspected neocortical seizure foci, particularly when other imaging modalities are unrevealing. However, a complex method, inherent variability, and increased binding in regions outside seizure foci will limit applicability." @default.
• W2947729118 created "2019-06-07" @default.
• W2947729118 creator A5017569213 @default.
• W2947729118 creator A5025613428 @default.
• W2947729118 creator A5035586136 @default.
• W2947729118 creator A5039918144 @default.
• W2947729118 creator A5039922442 @default.
• W2947729118 creator A5045476645 @default.
• W2947729118 creator A5062446814 @default.
• W2947729118 creator A5071058108 @default.
• W2947729118 date "2019-05-30" @default.
• W2947729118 modified "2023-10-11" @default.
• W2947729118 title "Neuroinflammation in neocortical epilepsy measured by PET imaging of translocator protein" @default.
• W2947729118 cites W1497620482 @default.
• W2947729118 cites W1511574140 @default.
• W2947729118 cites W1706474747 @default.
• W2947729118 cites W1968420305 @default.
• W2947729118 cites W1991623258 @default.
• W2947729118 cites W1993210323 @default.
• W2947729118 cites W2022981588 @default.
• W2947729118 cites W2043878814 @default.
• W2947729118 cites W2070424142 @default.
• W2947729118 cites W2076235934 @default.
• W2947729118 cites W2098849080 @default.
• W2947729118 cites W2125241815 @default.
• W2947729118 cites W2146894060 @default.
• W2947729118 cites W2150047376 @default.
• W2947729118 cites W2154119533 @default.
• W2947729118 cites W2169624917 @default.
• W2947729118 cites W2192584681 @default.
• W2947729118 cites W2327380846 @default.
• W2947729118 cites W2460109712 @default.
• W2947729118 cites W2467567247 @default.
• W2947729118 cites W2564185107 @default.
• W2947729118 cites W2604233127 @default.
• W2947729118 cites W2728610686 @default.
• W2947729118 cites W2729852799 @default.
• W2947729118 cites W2761267249 @default.
• W2947729118 cites W2763452490 @default.
• W2947729118 cites W2779020741 @default.
• W2947729118 cites W2793693515 @default.
• W2947729118 cites W2799649021 @default.
• W2947729118 cites W2801028001 @default.
• W2947729118 doi "https://doi.org/10.1111/epi.15967" @default.
• W2947729118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7268896" @default.
• W2947729118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31144767" @default.
• W2947729118 hasPublicationYear "2019" @default.
• W2947729118 type Work @default.
• W2947729118 sameAs 2947729118 @default.
• W2947729118 citedByCount "26" @default.
• W2947729118 countsByYear W29477291182019 @default.
• W2947729118 countsByYear W29477291182020 @default.
• W2947729118 countsByYear W29477291182021 @default.
• W2947729118 countsByYear W29477291182022 @default.
• W2947729118 countsByYear W29477291182023 @default.
• W2947729118 crossrefType "journal-article" @default.
• W2947729118 hasAuthorship W2947729118A5017569213 @default.
• W2947729118 hasAuthorship W2947729118A5025613428 @default.
• W2947729118 hasAuthorship W2947729118A5035586136 @default.
• W2947729118 hasAuthorship W2947729118A5039918144 @default.
• W2947729118 hasAuthorship W2947729118A5039922442 @default.
• W2947729118 hasAuthorship W2947729118A5045476645 @default.
• W2947729118 hasAuthorship W2947729118A5062446814 @default.
• W2947729118 hasAuthorship W2947729118A5071058108 @default.
• W2947729118 hasBestOaLocation W29477291182 @default.
• W2947729118 hasConcept C126322002 @default.
• W2947729118 hasConcept C126838900 @default.
• W2947729118 hasConcept C142724271 @default.
• W2947729118 hasConcept C143409427 @default.
• W2947729118 hasConcept C15744967 @default.
• W2947729118 hasConcept C169760540 @default.
• W2947729118 hasConcept C170493617 @default.
• W2947729118 hasConcept C17755696 @default.
• W2947729118 hasConcept C2775842073 @default.
• W2947729118 hasConcept C2776791281 @default.
• W2947729118 hasConcept C2777222312 @default.
• W2947729118 hasConcept C2778186239 @default.
• W2947729118 hasConcept C2779134260 @default.
• W2947729118 hasConcept C2781099131 @default.
• W2947729118 hasConcept C2989005 @default.
• W2947729118 hasConcept C522805319 @default.
• W2947729118 hasConcept C67847695 @default.
• W2947729118 hasConcept C71924100 @default.
• W2947729118 hasConcept C87753298 @default.
• W2947729118 hasConceptScore W2947729118C126322002 @default.
• W2947729118 hasConceptScore W2947729118C126838900 @default.
• W2947729118 hasConceptScore W2947729118C142724271 @default.
• W2947729118 hasConceptScore W2947729118C143409427 @default.
• W2947729118 hasConceptScore W2947729118C15744967 @default.
• W2947729118 hasConceptScore W2947729118C169760540 @default.
• W2947729118 hasConceptScore W2947729118C170493617 @default.
• W2947729118 hasConceptScore W2947729118C17755696 @default.
• W2947729118 hasConceptScore W2947729118C2775842073 @default.
• W2947729118 hasConceptScore W2947729118C2776791281 @default.
• W2947729118 hasConceptScore W2947729118C2777222312 @default.
• W2947729118 hasConceptScore W2947729118C2778186239 @default.
• W2947729118 hasConceptScore W2947729118C2779134260 @default.
• W2947729118 hasConceptScore W2947729118C2781099131 @default.

• next