Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947740532> ?p ?o ?g. }
- W2947740532 endingPage "1199" @default.
- W2947740532 startingPage "1187" @default.
- W2947740532 abstract "Traditional antitumor drugs inhibit the proliferation and metastasis of tumour cells by restraining the replication and expression of DNA. These drugs are usually highly cytotoxic. They kill tumour cells while also cause damage to normal cells at the same time, especially the hematopoietic cells that divide vigorously. Patients are exposed to other serious situations such as a severe infection caused by a decrease in the number of white blood cells. Energy metabolism is an essential process for the survival of all cells, but differs greatly between normal cells and tumour cells in metabolic pathways and metabolic intermediates. Whether this difference could be used as new therapeutic target while reducing damage to normal tissues is the topic of this paper. In this paper, we introduce five major metabolic intermediates in detail, including acetyl-CoA, SAM, FAD, NAD+ and THF. Their contents and functions in tumour cells and normal cells are significantly different. And the possible regulatory mechanisms that lead to these differences are proposed carefully. It is hoped that the key enzymes in these regulatory pathways could be used as new targets for tumour therapy." @default.
- W2947740532 created "2019-06-07" @default.
- W2947740532 creator A5000979147 @default.
- W2947740532 creator A5007280140 @default.
- W2947740532 creator A5021356241 @default.
- W2947740532 creator A5064558694 @default.
- W2947740532 creator A5070846943 @default.
- W2947740532 creator A5088332355 @default.
- W2947740532 date "2019-01-01" @default.
- W2947740532 modified "2023-10-18" @default.
- W2947740532 title "Metabolic Intermediates in Tumorigenesis and Progression" @default.
- W2947740532 cites W1530108768 @default.
- W2947740532 cites W1541927927 @default.
- W2947740532 cites W1553155385 @default.
- W2947740532 cites W1596235536 @default.
- W2947740532 cites W1807321331 @default.
- W2947740532 cites W1817033456 @default.
- W2947740532 cites W1820919423 @default.
- W2947740532 cites W1890418294 @default.
- W2947740532 cites W1936240797 @default.
- W2947740532 cites W1954584384 @default.
- W2947740532 cites W1961251946 @default.
- W2947740532 cites W1963479699 @default.
- W2947740532 cites W1971352608 @default.
- W2947740532 cites W1972254548 @default.
- W2947740532 cites W1972304747 @default.
- W2947740532 cites W1975346450 @default.
- W2947740532 cites W1976909598 @default.
- W2947740532 cites W1977622464 @default.
- W2947740532 cites W1980549694 @default.
- W2947740532 cites W1989674299 @default.
- W2947740532 cites W1994471840 @default.
- W2947740532 cites W1994687037 @default.
- W2947740532 cites W1996096670 @default.
- W2947740532 cites W1998968327 @default.
- W2947740532 cites W2003290318 @default.
- W2947740532 cites W2003872705 @default.
- W2947740532 cites W2004429137 @default.
- W2947740532 cites W2005378156 @default.
- W2947740532 cites W2005467138 @default.
- W2947740532 cites W2005830327 @default.
- W2947740532 cites W2018711046 @default.
- W2947740532 cites W2020016897 @default.
- W2947740532 cites W2022222857 @default.
- W2947740532 cites W2037877475 @default.
- W2947740532 cites W2038907283 @default.
- W2947740532 cites W2044515618 @default.
- W2947740532 cites W2049065822 @default.
- W2947740532 cites W2049943580 @default.
- W2947740532 cites W2052411385 @default.
- W2947740532 cites W2052729921 @default.
- W2947740532 cites W2056077438 @default.
- W2947740532 cites W2064437293 @default.
- W2947740532 cites W2064442490 @default.
- W2947740532 cites W2069157717 @default.
- W2947740532 cites W2069881412 @default.
- W2947740532 cites W2070151167 @default.
- W2947740532 cites W2072655765 @default.
- W2947740532 cites W2074517075 @default.
- W2947740532 cites W2097375610 @default.
- W2947740532 cites W2101893151 @default.
- W2947740532 cites W2107089340 @default.
- W2947740532 cites W2110054105 @default.
- W2947740532 cites W2110511887 @default.
- W2947740532 cites W2119406817 @default.
- W2947740532 cites W2120613751 @default.
- W2947740532 cites W2121956021 @default.
- W2947740532 cites W2129224931 @default.
- W2947740532 cites W2137781433 @default.
- W2947740532 cites W2139077902 @default.
- W2947740532 cites W2144575277 @default.
- W2947740532 cites W2151836995 @default.
- W2947740532 cites W2160627493 @default.
- W2947740532 cites W2178162055 @default.
- W2947740532 cites W2182977810 @default.
- W2947740532 cites W2188237389 @default.
- W2947740532 cites W2256771672 @default.
- W2947740532 cites W2286515888 @default.
- W2947740532 cites W2331098390 @default.
- W2947740532 cites W2342385616 @default.
- W2947740532 cites W2344299856 @default.
- W2947740532 cites W2345381093 @default.
- W2947740532 cites W2408992651 @default.
- W2947740532 cites W2415515169 @default.
- W2947740532 cites W2462012272 @default.
- W2947740532 cites W2507370326 @default.
- W2947740532 cites W2519942994 @default.
- W2947740532 cites W2519953954 @default.
- W2947740532 cites W2520894026 @default.
- W2947740532 cites W2526556847 @default.
- W2947740532 cites W2546991359 @default.
- W2947740532 cites W2549044484 @default.
- W2947740532 cites W2549856864 @default.
- W2947740532 cites W2559757114 @default.
- W2947740532 cites W2586445984 @default.
- W2947740532 cites W2593306572 @default.
- W2947740532 cites W2607465958 @default.
- W2947740532 cites W2610368603 @default.