FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947746652> ?p ?o ?g. }

• W2947746652 abstract "Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functionality is partly attributable to genetically determined factors, has been suggested to play an important role. The treatment of acute attacks and the prophylactic management of chronic forms include the use of different category of drugs, and it is demonstrated that not each subject has the same clinical answer to them. The reason of this is to be searched in different functional capacity and quantity of phase I enzymes (such as different isoforms of CYP P450), phase II enzymes (such as UDP-glucuronosyltransferases), receptors (such as OPRM1 for opioids) and transporters (such as ABCB1) involved in the metabolic destiny of each drug, all of these dictated by DNA and RNA variations. The general picture is further exacerbated by the need for polytherapies, often also to treat comorbidities, which may interfere with the pharmacological action of anti-migraine drugs. Personalized medicine has the objective of setting the optimal therapies in the light of the functional biochemical asset and of the comorbidities of the individual patient, in order to obtain the best clinical response. Novel therapeutic perspectives in migraine includes biotechnological drugs directed against molecules (such as CGRP and its receptor) that cause vasodilatation at the peripheral level of the meningeal blood vessels and reflex stimulation of the parasympathetic system. Drug-drug interactions and the possible competitive metabolic destiny should be studied by the application of pharmacogenomics in large scale. Drug-drug interactions and their possible competitive metabolic destiny should be studied by the application of pharmacogenomics in large scale." @default.
• W2947746652 created "2019-06-07" @default.
• W2947746652 creator A5001693795 @default.
• W2947746652 creator A5008323754 @default.
• W2947746652 creator A5012758715 @default.
• W2947746652 creator A5022850964 @default.
• W2947746652 creator A5035469274 @default.
• W2947746652 creator A5076655124 @default.
• W2947746652 date "2019-05-17" @default.
• W2947746652 modified "2023-10-16" @default.
• W2947746652 title "Optimising migraine treatment: from drug-drug interactions to personalized medicine" @default.
• W2947746652 cites W113990517 @default.
• W2947746652 cites W1949535248 @default.
• W2947746652 cites W1965228291 @default.
• W2947746652 cites W1968814844 @default.
• W2947746652 cites W1976400419 @default.
• W2947746652 cites W1976960945 @default.
• W2947746652 cites W1979269791 @default.
• W2947746652 cites W1979456235 @default.
• W2947746652 cites W1979566817 @default.
• W2947746652 cites W1988806962 @default.
• W2947746652 cites W1989422046 @default.
• W2947746652 cites W1991932809 @default.
• W2947746652 cites W1996295044 @default.
• W2947746652 cites W2001038308 @default.
• W2947746652 cites W2012155809 @default.
• W2947746652 cites W2012240811 @default.
• W2947746652 cites W2021355359 @default.
• W2947746652 cites W2021635654 @default.
• W2947746652 cites W2025877137 @default.
• W2947746652 cites W2028643581 @default.
• W2947746652 cites W2032934830 @default.
• W2947746652 cites W2038609326 @default.
• W2947746652 cites W2041917695 @default.
• W2947746652 cites W2043981148 @default.
• W2947746652 cites W2045328772 @default.
• W2947746652 cites W2048132386 @default.
• W2947746652 cites W2051083109 @default.
• W2947746652 cites W2055122753 @default.
• W2947746652 cites W2057694616 @default.
• W2947746652 cites W2063644292 @default.
• W2947746652 cites W2066259768 @default.
• W2947746652 cites W2069818433 @default.
• W2947746652 cites W2070921940 @default.
• W2947746652 cites W2073128000 @default.
• W2947746652 cites W2085595272 @default.
• W2947746652 cites W2086709699 @default.
• W2947746652 cites W2090820748 @default.
• W2947746652 cites W2098389482 @default.
• W2947746652 cites W2102115790 @default.
• W2947746652 cites W2109989116 @default.
• W2947746652 cites W2115215127 @default.
• W2947746652 cites W2116118927 @default.
• W2947746652 cites W2121074897 @default.
• W2947746652 cites W2123219153 @default.
• W2947746652 cites W2125066141 @default.
• W2947746652 cites W2128341591 @default.
• W2947746652 cites W2148445312 @default.
• W2947746652 cites W2154114188 @default.
• W2947746652 cites W2224177558 @default.
• W2947746652 cites W2303748698 @default.
• W2947746652 cites W2342696216 @default.
• W2947746652 cites W2510330387 @default.
• W2947746652 cites W2587197879 @default.
• W2947746652 cites W2607327290 @default.
• W2947746652 cites W2614765539 @default.
• W2947746652 cites W2617432961 @default.
• W2947746652 cites W2766819558 @default.
• W2947746652 cites W2793230886 @default.
• W2947746652 cites W2802627455 @default.
• W2947746652 cites W2807571842 @default.
• W2947746652 cites W2808796075 @default.
• W2947746652 cites W2895334558 @default.
• W2947746652 cites W2901869599 @default.
• W2947746652 cites W2902063133 @default.
• W2947746652 cites W2942475402 @default.
• W2947746652 cites W4247292047 @default.
• W2947746652 cites W99605343 @default.
• W2947746652 cites W1989927213 @default.
• W2947746652 doi "https://doi.org/10.1186/s10194-019-1010-3" @default.
• W2947746652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6734220" @default.
• W2947746652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31101004" @default.
• W2947746652 hasPublicationYear "2019" @default.
• W2947746652 type Work @default.
• W2947746652 sameAs 2947746652 @default.
• W2947746652 citedByCount "38" @default.
• W2947746652 countsByYear W29477466522019 @default.
• W2947746652 countsByYear W29477466522020 @default.
• W2947746652 countsByYear W29477466522021 @default.
• W2947746652 countsByYear W29477466522022 @default.
• W2947746652 countsByYear W29477466522023 @default.
• W2947746652 crossrefType "journal-article" @default.
• W2947746652 hasAuthorship W2947746652A5001693795 @default.
• W2947746652 hasAuthorship W2947746652A5008323754 @default.
• W2947746652 hasAuthorship W2947746652A5012758715 @default.
• W2947746652 hasAuthorship W2947746652A5022850964 @default.
• W2947746652 hasAuthorship W2947746652A5035469274 @default.
• W2947746652 hasAuthorship W2947746652A5076655124 @default.
• W2947746652 hasBestOaLocation W29477466521 @default.
• W2947746652 hasConcept C104317684 @default.

• next