Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947746870> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2947746870 endingPage "441" @default.
- W2947746870 startingPage "435" @default.
- W2947746870 abstract "Studies suggest that hydrogen sulfide (H2S) plays a relevant and beneficial role in the pathophysiology of pulmonary allergic diseases, such as asthma. These diseases may be triggered by changes in airway epithelium caused by repeated exposure to environmental allergens. This study aimed to investigate whether H2S protects against bronchial epithelium apoptosis in allergic inflammation in mice. The effects of H2S on the production of Th2 cytokines and on the infiltration of pulmonary inflammatory cells were also studied. Female BALB/c mice previously sensitized with ovalbumin (OVA) were treated with H2S donor (sodium hydrosulfide [NaHS]) 30 min prior to OVA challenge. After euthanasia (48 h post challenge), the right lung was homogenized to study apoptosis protein expression and to analyze cytokine levels in lung tissue. The left lobe was fixed in formalin for morphological analysis of lung tissue and verification of apoptosis in situ by the TUNEL assay. Histological results showed that NaHS reduced the airway inflammatory infiltrate and prevented an increase in the IL-4, IL-5 and IL-25 levels caused by OVA challenge. Activation of caspase 3 and FasL in response to the allergen was also fully prevented by NaHS treatment. TUNEL staining showed that the challenge from OVA significantly increased the rate of apoptosis in the bronchiolar epithelium, and that this incremental apoptosis was abolished by NaHS treatment. In conclusion, our results showed that H2S donor has a protective effect against airway epithelium damage caused by an allergic reaction, and represents a potential agent in treating allergic lung disorders, such as asthma." @default.
- W2947746870 created "2019-06-07" @default.
- W2947746870 creator A5007350398 @default.
- W2947746870 creator A5016698620 @default.
- W2947746870 creator A5017509356 @default.
- W2947746870 creator A5023110023 @default.
- W2947746870 creator A5060038476 @default.
- W2947746870 creator A5060879543 @default.
- W2947746870 creator A5079205300 @default.
- W2947746870 date "2019-08-01" @default.
- W2947746870 modified "2023-09-24" @default.
- W2947746870 title "Hydrogen sulfide inhibits apoptosis and protects the bronchial epithelium in an allergic inflammation mice model" @default.
- W2947746870 cites W1964155163 @default.
- W2947746870 cites W1996770096 @default.
- W2947746870 cites W2000548935 @default.
- W2947746870 cites W2014515422 @default.
- W2947746870 cites W2073874729 @default.
- W2947746870 cites W2094671428 @default.
- W2947746870 cites W2117559606 @default.
- W2947746870 cites W2170299167 @default.
- W2947746870 cites W2209665340 @default.
- W2947746870 cites W2490178587 @default.
- W2947746870 cites W2724412839 @default.
- W2947746870 cites W2731034157 @default.
- W2947746870 cites W2759040626 @default.
- W2947746870 cites W2795748093 @default.
- W2947746870 doi "https://doi.org/10.1016/j.intimp.2019.05.041" @default.
- W2947746870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31154288" @default.
- W2947746870 hasPublicationYear "2019" @default.
- W2947746870 type Work @default.
- W2947746870 sameAs 2947746870 @default.
- W2947746870 citedByCount "18" @default.
- W2947746870 countsByYear W29477468702020 @default.
- W2947746870 countsByYear W29477468702021 @default.
- W2947746870 countsByYear W29477468702022 @default.
- W2947746870 countsByYear W29477468702023 @default.
- W2947746870 crossrefType "journal-article" @default.
- W2947746870 hasAuthorship W2947746870A5007350398 @default.
- W2947746870 hasAuthorship W2947746870A5016698620 @default.
- W2947746870 hasAuthorship W2947746870A5017509356 @default.
- W2947746870 hasAuthorship W2947746870A5023110023 @default.
- W2947746870 hasAuthorship W2947746870A5060038476 @default.
- W2947746870 hasAuthorship W2947746870A5060879543 @default.
- W2947746870 hasAuthorship W2947746870A5079205300 @default.
- W2947746870 hasConcept C126322002 @default.
- W2947746870 hasConcept C142724271 @default.
- W2947746870 hasConcept C185592680 @default.
- W2947746870 hasConcept C190283241 @default.
- W2947746870 hasConcept C196795494 @default.
- W2947746870 hasConcept C203014093 @default.
- W2947746870 hasConcept C204232928 @default.
- W2947746870 hasConcept C2776914184 @default.
- W2947746870 hasConcept C2776946954 @default.
- W2947746870 hasConcept C2777714996 @default.
- W2947746870 hasConcept C2778690821 @default.
- W2947746870 hasConcept C2779675166 @default.
- W2947746870 hasConcept C529295009 @default.
- W2947746870 hasConcept C55493867 @default.
- W2947746870 hasConcept C71924100 @default.
- W2947746870 hasConcept C87568996 @default.
- W2947746870 hasConcept C8891405 @default.
- W2947746870 hasConceptScore W2947746870C126322002 @default.
- W2947746870 hasConceptScore W2947746870C142724271 @default.
- W2947746870 hasConceptScore W2947746870C185592680 @default.
- W2947746870 hasConceptScore W2947746870C190283241 @default.
- W2947746870 hasConceptScore W2947746870C196795494 @default.
- W2947746870 hasConceptScore W2947746870C203014093 @default.
- W2947746870 hasConceptScore W2947746870C204232928 @default.
- W2947746870 hasConceptScore W2947746870C2776914184 @default.
- W2947746870 hasConceptScore W2947746870C2776946954 @default.
- W2947746870 hasConceptScore W2947746870C2777714996 @default.
- W2947746870 hasConceptScore W2947746870C2778690821 @default.
- W2947746870 hasConceptScore W2947746870C2779675166 @default.
- W2947746870 hasConceptScore W2947746870C529295009 @default.
- W2947746870 hasConceptScore W2947746870C55493867 @default.
- W2947746870 hasConceptScore W2947746870C71924100 @default.
- W2947746870 hasConceptScore W2947746870C87568996 @default.
- W2947746870 hasConceptScore W2947746870C8891405 @default.
- W2947746870 hasFunder F4320320997 @default.
- W2947746870 hasLocation W29477468701 @default.
- W2947746870 hasLocation W29477468702 @default.
- W2947746870 hasOpenAccess W2947746870 @default.
- W2947746870 hasPrimaryLocation W29477468701 @default.
- W2947746870 hasRelatedWork W1651112321 @default.
- W2947746870 hasRelatedWork W1753565883 @default.
- W2947746870 hasRelatedWork W1984300559 @default.
- W2947746870 hasRelatedWork W2054378706 @default.
- W2947746870 hasRelatedWork W2109032237 @default.
- W2947746870 hasRelatedWork W2114335715 @default.
- W2947746870 hasRelatedWork W2117611528 @default.
- W2947746870 hasRelatedWork W2129022159 @default.
- W2947746870 hasRelatedWork W2410843682 @default.
- W2947746870 hasRelatedWork W2946656627 @default.
- W2947746870 hasVolume "73" @default.
- W2947746870 isParatext "false" @default.
- W2947746870 isRetracted "false" @default.
- W2947746870 magId "2947746870" @default.
- W2947746870 workType "article" @default.