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- W2947762662 abstract "Abstract The human prolyl isomerase PIN 1, best known for its association with carcinogenesis, has recently been indicated in the disease of pancreatic ductal adenocarcinoma (PDAC). However, the functions of PIN 1 and the feasibility of targeting PIN 1 in PDAC remain elusive. For this purpose, we examined the expression of PIN 1 in cancer, related paracarcinoma and metastatic cancer tissues by immunohistochemistry and analyzed the associations with the pathogenesis of PDAC in 173 patients. The functional roles of PIN 1 in PDAC were explored in vitro and in vivo using both genetic and chemical PIN 1 inhibition. We showed that PIN 1 was upregulated in pancreatic cancer and metastatic tissues. High PIN 1 expression is significantly association with poor clinicopathological features and shorter overall survival and disease‐free survival. Further stratified analysis showed that PIN 1 phenotypes refined prognostication in PDAC . Inhibition of PIN 1 expression with RNA interference or with all trans retinoic acid decreased not only the growth but also the migration and invasion of PDAC cells through regulating the key molecules of multiple cancer‐driving pathways, simultaneously resulting in cell cycle arrest and mesenchymal‐epithelial transition in vitro. Furthermore, genetic and chemical PIN 1 ablation showed dramatic inhibition of the tumorigenesis and metastatic spread and then reduced the tumor burden in vivo. We provided further evidence for the use of PIN 1 as a promising therapeutic target in PDAC . Genetic and chemical PIN 1 ablation exerted potent antitumor effects through blocking multiple cancer‐driving pathways in PDAC . More potent and specific PIN 1 targeted inhibitors could be exploited to treat this aggressive cancer." @default.
- W2947762662 created "2019-06-07" @default.
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- W2947762662 date "2019-06-25" @default.
- W2947762662 modified "2023-09-26" @default.
- W2947762662 title "Targeting <scp>PIN</scp> 1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis" @default.
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- W2947762662 doi "https://doi.org/10.1111/cas.14085" @default.
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