Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947762829> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2947762829 abstract "568 Background: The goal was to develop and validate a biologic signature for 10-year ipsilateral invasive breast event (IBE) risk in luminal Stage 1 breast cancer (BC) patients treated surgically and either with or without radiation therapy (RT). Methods: This cohort was from Uppsala University and Västerås Hospitals diagnosed with Stage 1 BC and treated surgically between 1987 and 2004. Treatment was neither randomized nor strictly rules based, including adjuvant RT, Hormone Therapy (HT), and Chemotherapy (CT). Biomarkers (HER2, PR, Ki67, COX2, p16/INK4A, FOXA1 and SIAH2) were assessed on tissue microarrays in PreludeDx’s CLIA lab by board-certified pathologists. Risk groups were calculated using biomarkers and clinical factors age and size. A multivariate Cox proportional hazards analysis was used to determine hazard ratio for biologic signature. 10-year IBE risk was assessed using Kaplan-Meier survival analysis. Results: There were 423 luminal cases with biomarker data having 54 IBEs, and a median follow-up of 11.8 years. There were 372 patients treated with BCS and 51 with Mastectomy, and 325 received RT, 169 received HT, and 47 received CT. In a multivariate analysis, the biologic signature (HR = 1.6, p = 0.019) and RT (HR = 0.51, p = 0.027) were associated with IBE risk adjusting for other treatments (HT and CT) and Luminal A status (p = 0.37). For patients over 50 yrs of age with luminal A disease and treated without CT (n = 205), an elevated biologic signature identified a subset of patients with a 15% (+/- 14%) 10-year IBE risk without RT (n = 38) compared to a 4% (+/-6%) IBE risk with RT (n = 72), while patients with a low biologic signature had a 10-year IBE risk of 4% (+/- 4%) without RT (n = 26) and 3% (+/-5%) IBE risk with RT (n = 69). Conclusions: With further prospective validation, the biologic signature identified herein may provide a tool enabling improved management for women diagnosed with early luminal BC." @default.
- W2947762829 created "2019-06-07" @default.
- W2947762829 creator A5013903847 @default.
- W2947762829 creator A5026403379 @default.
- W2947762829 creator A5034230229 @default.
- W2947762829 creator A5058339065 @default.
- W2947762829 creator A5058457453 @default.
- W2947762829 creator A5080583620 @default.
- W2947762829 date "2019-05-20" @default.
- W2947762829 modified "2023-09-25" @default.
- W2947762829 title "Risk stratification in earl- stage luminal breast cancer patients treated with and without RT." @default.
- W2947762829 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.568" @default.
- W2947762829 hasPublicationYear "2019" @default.
- W2947762829 type Work @default.
- W2947762829 sameAs 2947762829 @default.
- W2947762829 citedByCount "2" @default.
- W2947762829 countsByYear W29477628292021 @default.
- W2947762829 countsByYear W29477628292022 @default.
- W2947762829 crossrefType "journal-article" @default.
- W2947762829 hasAuthorship W2947762829A5013903847 @default.
- W2947762829 hasAuthorship W2947762829A5026403379 @default.
- W2947762829 hasAuthorship W2947762829A5034230229 @default.
- W2947762829 hasAuthorship W2947762829A5058339065 @default.
- W2947762829 hasAuthorship W2947762829A5058457453 @default.
- W2947762829 hasAuthorship W2947762829A5080583620 @default.
- W2947762829 hasConcept C121608353 @default.
- W2947762829 hasConcept C126322002 @default.
- W2947762829 hasConcept C143998085 @default.
- W2947762829 hasConcept C146357865 @default.
- W2947762829 hasConcept C151730666 @default.
- W2947762829 hasConcept C3020404979 @default.
- W2947762829 hasConcept C530470458 @default.
- W2947762829 hasConcept C71924100 @default.
- W2947762829 hasConcept C86803240 @default.
- W2947762829 hasConceptScore W2947762829C121608353 @default.
- W2947762829 hasConceptScore W2947762829C126322002 @default.
- W2947762829 hasConceptScore W2947762829C143998085 @default.
- W2947762829 hasConceptScore W2947762829C146357865 @default.
- W2947762829 hasConceptScore W2947762829C151730666 @default.
- W2947762829 hasConceptScore W2947762829C3020404979 @default.
- W2947762829 hasConceptScore W2947762829C530470458 @default.
- W2947762829 hasConceptScore W2947762829C71924100 @default.
- W2947762829 hasConceptScore W2947762829C86803240 @default.
- W2947762829 hasLocation W29477628291 @default.
- W2947762829 hasOpenAccess W2947762829 @default.
- W2947762829 hasPrimaryLocation W29477628291 @default.
- W2947762829 hasRelatedWork W163225359 @default.
- W2947762829 hasRelatedWork W1981147566 @default.
- W2947762829 hasRelatedWork W1993246749 @default.
- W2947762829 hasRelatedWork W2014160156 @default.
- W2947762829 hasRelatedWork W2084272673 @default.
- W2947762829 hasRelatedWork W2203649236 @default.
- W2947762829 hasRelatedWork W2250329042 @default.
- W2947762829 hasRelatedWork W2408780582 @default.
- W2947762829 hasRelatedWork W2432133031 @default.
- W2947762829 hasRelatedWork W2622150343 @default.
- W2947762829 hasRelatedWork W2883203194 @default.
- W2947762829 hasRelatedWork W2979727445 @default.
- W2947762829 hasRelatedWork W2993659273 @default.
- W2947762829 hasRelatedWork W3025675297 @default.
- W2947762829 hasRelatedWork W3198260320 @default.
- W2947762829 hasRelatedWork W3202968546 @default.
- W2947762829 hasRelatedWork W332757656 @default.
- W2947762829 hasRelatedWork W399392294 @default.
- W2947762829 hasRelatedWork W58151021 @default.
- W2947762829 hasRelatedWork W2884027452 @default.
- W2947762829 isParatext "false" @default.
- W2947762829 isRetracted "false" @default.
- W2947762829 magId "2947762829" @default.
- W2947762829 workType "article" @default.