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- W2947763145 abstract "objective To investigate the expressions and significance of β-arrestin1 and matrix metalloproteinase-9(MMP-9) in hepatocecullar carcinoma patients.Methods The tumor tissues and tumor-adjacent tissues were simultaneously collected from 35 patients in operation with diagnosed hepatocellular carcinoma,which included 23 cases of phase Ⅱ and 12 cases of phase Ⅲ.And 15 non-tumor tissues were enrolled in this study as the normal control(NL group).Then the mRNA and protein expression of β-arrestin1 were detected by using quantitative real-time RT-PCR and Western blot respectively.The protein concentration of MMP-9 of these tissues was measured by ELISA.Results All the mRNA and protein expressions of β-arrestin1 were measured in the samples of normal liver tissues,HCC tumor and its adjacent tissues.Compared with the normal group and tumor-adjacent group,the mRNA and protein expressions of β-arrestin1 in HCC group of different clinical phases increased significantly(P0.05).The expression level was increased with the advanced phases.The concentration of MMP-9,increased in HCC tumor tissues,was positively correlated with β-arrestin1 expreesion(P0.05).Conclusion The expressions of β-arrestin1 significantly up-regulated in HCC tumor tissues,which was positively related to the concentration of MMP-9,indicating that they might be related to progression of hepartocecullar carcinoma and to be the diagnosis and therapy target of HCC." @default.
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- W2947763145 date "2011-02-25" @default.
- W2947763145 modified "2023-09-23" @default.
- W2947763145 title "Correlative Expressions of β-arrestin1 and MMP-9 in Hepatocelluar Carcinoma Tissues" @default.
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