FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947791363> ?p ?o ?g. }

• W2947791363 endingPage "530" @default.
• W2947791363 startingPage "530" @default.
• W2947791363 abstract "The level of cerebellar activity in stroke patients has been shown to correlate with the extent of functional recovery. We reasoned that the cerebellum may be an important player in post-stroke rehabilitation. Because the neurons in the deep cerebellar nuclei (DCN) represent virtually all of the output from the cerebellum, in this study, using environmental enrichment (EE) to promote rehabilitation, we investigated the influence of the optogenetic neuronal modulation of DCN on EE-induced rehabilitation. We found that neuronal inhibition of the DCN almost completely blocked motor recovery in EE treated mice, but the stroke mice with neuronal activation of the DCN achieved a similar recovery level as those in the EE treated group. No difference was observed in anxiety-like behavior. Moreover, <i>Htr2a</i> in the DCN, the gene encoding <i>5-HT2A</i> receptor, was shown to be a hub gene in the protein-protein interaction network identified using RNA-seq. This indicated that <i>5-HT2A</i> receptor-mediated signaling may be responsible for DCN-dependent functional improvement in EE. We further verified this using the <i>5-HT2A</i> receptor antagonist, MDL100907, to inhibit the function of <i>5-HT2A</i> receptor in the DCN. This treatment resulted in impaired recovery in EE treated mice, who performed at a level as poor as the stroke-only group. Thus, this work contributes to an understanding of the importance of the DCN activation in EE-induced post-stroke rehabilitation. Attempts to clarify the mechanism of <i>5-HT2A</i> receptor-mediated signaling in the DCN may also lead to the creation of a pharmacological mimetic of the benefits of EE-induced rehabilitation." @default.
• W2947791363 created "2019-06-07" @default.
• W2947791363 creator A5014577954 @default.
• W2947791363 creator A5015599289 @default.
• W2947791363 creator A5016888447 @default.
• W2947791363 creator A5028490219 @default.
• W2947791363 creator A5037090736 @default.
• W2947791363 creator A5055258635 @default.
• W2947791363 creator A5079060559 @default.
• W2947791363 creator A5081405502 @default.
• W2947791363 date "2019-01-01" @default.
• W2947791363 modified "2023-09-28" @default.
• W2947791363 title "The Neuronal Activation of Deep Cerebellar Nuclei Is Essential for Environmental Enrichment-Induced Post-Stroke Motor Recovery" @default.
• W2947791363 cites W1969514423 @default.
• W2947791363 cites W1980143688 @default.
• W2947791363 cites W1983746474 @default.
• W2947791363 cites W1988810162 @default.
• W2947791363 cites W2009134620 @default.
• W2947791363 cites W2011010963 @default.
• W2947791363 cites W2011109794 @default.
• W2947791363 cites W2038401908 @default.
• W2947791363 cites W2038699322 @default.
• W2947791363 cites W2040847131 @default.
• W2947791363 cites W2054691158 @default.
• W2947791363 cites W2062124861 @default.
• W2947791363 cites W2063528788 @default.
• W2947791363 cites W2064301927 @default.
• W2947791363 cites W2065602929 @default.
• W2947791363 cites W2075956475 @default.
• W2947791363 cites W2090264922 @default.
• W2947791363 cites W2105533062 @default.
• W2947791363 cites W2109500726 @default.
• W2947791363 cites W2140516726 @default.
• W2947791363 cites W2147214889 @default.
• W2947791363 cites W2331389479 @default.
• W2947791363 cites W2339700702 @default.
• W2947791363 cites W2512405359 @default.
• W2947791363 cites W2522229132 @default.
• W2947791363 cites W2621272416 @default.
• W2947791363 cites W2762611248 @default.
• W2947791363 cites W2805034086 @default.
• W2947791363 doi "https://doi.org/10.14336/ad.2018.1220" @default.
• W2947791363 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6538218" @default.
• W2947791363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31164998" @default.
• W2947791363 hasPublicationYear "2019" @default.
• W2947791363 type Work @default.
• W2947791363 sameAs 2947791363 @default.
• W2947791363 citedByCount "12" @default.
• W2947791363 countsByYear W29477913632020 @default.
• W2947791363 countsByYear W29477913632021 @default.
• W2947791363 countsByYear W29477913632022 @default.
• W2947791363 countsByYear W29477913632023 @default.
• W2947791363 crossrefType "journal-article" @default.
• W2947791363 hasAuthorship W2947791363A5014577954 @default.
• W2947791363 hasAuthorship W2947791363A5015599289 @default.
• W2947791363 hasAuthorship W2947791363A5016888447 @default.
• W2947791363 hasAuthorship W2947791363A5028490219 @default.
• W2947791363 hasAuthorship W2947791363A5037090736 @default.
• W2947791363 hasAuthorship W2947791363A5055258635 @default.
• W2947791363 hasAuthorship W2947791363A5079060559 @default.
• W2947791363 hasAuthorship W2947791363A5081405502 @default.
• W2947791363 hasBestOaLocation W29477913631 @default.
• W2947791363 hasConcept C126322002 @default.
• W2947791363 hasConcept C127413603 @default.
• W2947791363 hasConcept C15744967 @default.
• W2947791363 hasConcept C169760540 @default.
• W2947791363 hasConcept C170493617 @default.
• W2947791363 hasConcept C185592680 @default.
• W2947791363 hasConcept C2776885963 @default.
• W2947791363 hasConcept C2778122271 @default.
• W2947791363 hasConcept C2778818304 @default.
• W2947791363 hasConcept C2779652256 @default.
• W2947791363 hasConcept C2780645631 @default.
• W2947791363 hasConcept C50738837 @default.
• W2947791363 hasConcept C53927964 @default.
• W2947791363 hasConcept C71924100 @default.
• W2947791363 hasConcept C78519656 @default.
• W2947791363 hasConcept C98274493 @default.
• W2947791363 hasConceptScore W2947791363C126322002 @default.
• W2947791363 hasConceptScore W2947791363C127413603 @default.
• W2947791363 hasConceptScore W2947791363C15744967 @default.
• W2947791363 hasConceptScore W2947791363C169760540 @default.
• W2947791363 hasConceptScore W2947791363C170493617 @default.
• W2947791363 hasConceptScore W2947791363C185592680 @default.
• W2947791363 hasConceptScore W2947791363C2776885963 @default.
• W2947791363 hasConceptScore W2947791363C2778122271 @default.
• W2947791363 hasConceptScore W2947791363C2778818304 @default.
• W2947791363 hasConceptScore W2947791363C2779652256 @default.
• W2947791363 hasConceptScore W2947791363C2780645631 @default.
• W2947791363 hasConceptScore W2947791363C50738837 @default.
• W2947791363 hasConceptScore W2947791363C53927964 @default.
• W2947791363 hasConceptScore W2947791363C71924100 @default.
• W2947791363 hasConceptScore W2947791363C78519656 @default.
• W2947791363 hasConceptScore W2947791363C98274493 @default.
• W2947791363 hasIssue "3" @default.
• W2947791363 hasLocation W29477913631 @default.
• W2947791363 hasLocation W29477913632 @default.
• W2947791363 hasLocation W29477913633 @default.

• next