Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947795259> ?p ?o ?g. }
- W2947795259 abstract "Abstract Glycans from microbial pathogens are well known pathogen-associated molecular patterns that are recognized by the host immunity; however, little is known about whether and how mammalian self-glycans activate the host immune response, especially in the context of autoimmune disease. Using biochemical fractionation and two-dimensional HPLC, we identify an abundant and bioactive free glycan, the Manβ1-4GlcNAc disaccharide in TREX1 -associated autoimmune diseases. We report that both monosaccharide residues and the β1-4 linkage are critical for bioactivity of this disaccharide. We also show that Manβ1-4GlcNAc is produced by oligosaccharyltransferase hydrolysis of lipid-linked oligosaccharides in the ER lumen, followed by ENGase and mannosidase processing in the cytosol and lysosomes. Furthermore, synthetic Manβ1-4GlcNAc disaccharide stimulates a broad immune response in vitro, which is in part dependent on the STING-TBK1 pathway, and enhances antibody response in vivo. Together, our data identify Manβ1-4GlcNAc as a novel innate immune modulator associated with chronic autoimmune diseases." @default.
- W2947795259 created "2019-06-07" @default.
- W2947795259 creator A5005763812 @default.
- W2947795259 creator A5009512429 @default.
- W2947795259 creator A5015904369 @default.
- W2947795259 creator A5021708601 @default.
- W2947795259 creator A5035676180 @default.
- W2947795259 creator A5049484621 @default.
- W2947795259 creator A5054250942 @default.
- W2947795259 creator A5055538365 @default.
- W2947795259 creator A5062582914 @default.
- W2947795259 creator A5085906797 @default.
- W2947795259 creator A5091842211 @default.
- W2947795259 date "2019-05-30" @default.
- W2947795259 modified "2023-10-10" @default.
- W2947795259 title "A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response" @default.
- W2947795259 cites W1547219449 @default.
- W2947795259 cites W1679212086 @default.
- W2947795259 cites W1852165898 @default.
- W2947795259 cites W1974351333 @default.
- W2947795259 cites W1986136379 @default.
- W2947795259 cites W1991131535 @default.
- W2947795259 cites W2007107152 @default.
- W2947795259 cites W2013286531 @default.
- W2947795259 cites W2017710096 @default.
- W2947795259 cites W2021148292 @default.
- W2947795259 cites W2025259722 @default.
- W2947795259 cites W2027940112 @default.
- W2947795259 cites W2029406542 @default.
- W2947795259 cites W2034525878 @default.
- W2947795259 cites W2039021127 @default.
- W2947795259 cites W2041153925 @default.
- W2947795259 cites W2042510427 @default.
- W2947795259 cites W2043959346 @default.
- W2947795259 cites W2046355713 @default.
- W2947795259 cites W2057539094 @default.
- W2947795259 cites W2075172390 @default.
- W2947795259 cites W2100704940 @default.
- W2947795259 cites W2116778443 @default.
- W2947795259 cites W2123583755 @default.
- W2947795259 cites W2134952032 @default.
- W2947795259 cites W2135896978 @default.
- W2947795259 cites W2142574184 @default.
- W2947795259 cites W2157563184 @default.
- W2947795259 cites W2157602573 @default.
- W2947795259 cites W2164224942 @default.
- W2947795259 cites W2292286849 @default.
- W2947795259 cites W2403391528 @default.
- W2947795259 cites W2500542777 @default.
- W2947795259 cites W2569540328 @default.
- W2947795259 cites W2595624457 @default.
- W2947795259 cites W2596815322 @default.
- W2947795259 cites W2612363400 @default.
- W2947795259 doi "https://doi.org/10.1038/s41467-019-10319-5" @default.
- W2947795259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6542856" @default.
- W2947795259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31147550" @default.
- W2947795259 hasPublicationYear "2019" @default.
- W2947795259 type Work @default.
- W2947795259 sameAs 2947795259 @default.
- W2947795259 citedByCount "18" @default.
- W2947795259 countsByYear W29477952592020 @default.
- W2947795259 countsByYear W29477952592021 @default.
- W2947795259 countsByYear W29477952592022 @default.
- W2947795259 countsByYear W29477952592023 @default.
- W2947795259 crossrefType "journal-article" @default.
- W2947795259 hasAuthorship W2947795259A5005763812 @default.
- W2947795259 hasAuthorship W2947795259A5009512429 @default.
- W2947795259 hasAuthorship W2947795259A5015904369 @default.
- W2947795259 hasAuthorship W2947795259A5021708601 @default.
- W2947795259 hasAuthorship W2947795259A5035676180 @default.
- W2947795259 hasAuthorship W2947795259A5049484621 @default.
- W2947795259 hasAuthorship W2947795259A5054250942 @default.
- W2947795259 hasAuthorship W2947795259A5055538365 @default.
- W2947795259 hasAuthorship W2947795259A5062582914 @default.
- W2947795259 hasAuthorship W2947795259A5085906797 @default.
- W2947795259 hasAuthorship W2947795259A5091842211 @default.
- W2947795259 hasBestOaLocation W29477952591 @default.
- W2947795259 hasConcept C108625454 @default.
- W2947795259 hasConcept C136449434 @default.
- W2947795259 hasConcept C203014093 @default.
- W2947795259 hasConcept C206212055 @default.
- W2947795259 hasConcept C2777346074 @default.
- W2947795259 hasConcept C2780868878 @default.
- W2947795259 hasConcept C55493867 @default.
- W2947795259 hasConcept C86803240 @default.
- W2947795259 hasConcept C8891405 @default.
- W2947795259 hasConcept C89423630 @default.
- W2947795259 hasConceptScore W2947795259C108625454 @default.
- W2947795259 hasConceptScore W2947795259C136449434 @default.
- W2947795259 hasConceptScore W2947795259C203014093 @default.
- W2947795259 hasConceptScore W2947795259C206212055 @default.
- W2947795259 hasConceptScore W2947795259C2777346074 @default.
- W2947795259 hasConceptScore W2947795259C2780868878 @default.
- W2947795259 hasConceptScore W2947795259C55493867 @default.
- W2947795259 hasConceptScore W2947795259C86803240 @default.
- W2947795259 hasConceptScore W2947795259C8891405 @default.
- W2947795259 hasConceptScore W2947795259C89423630 @default.
- W2947795259 hasFunder F4320306196 @default.
- W2947795259 hasFunder F4320313227 @default.
- W2947795259 hasFunder F4320337354 @default.