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- W2947814407 abstract "Antipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat dementia. We investigated the inhibitory effects of 26 antipsychotics on [N-Methyl-3H]scopolamine specific binding in mouse cerebral cortex. At 10-5 M, chlorpromazine, levomepromazine, prochlorperazine, timiperone, zotepine, pimozide, blonanserin, olanzapine, quetiapine, and clozapine inhibited [N-Methyl-3H]scopolamine binding by > 45%. Furthermore, the pKi values of chlorpromazine, levomepromazine, zotepine, olanzapine, and clozapine overlapped with their clinically achievable blood concentrations. Therefore, the anticholinergic properties of these antipsychotics could attenuate the effects of cholinesterase inhibitors." @default.
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- W2947814407 date "2019-06-01" @default.
- W2947814407 modified "2023-09-27" @default.
- W2947814407 title "Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex" @default.
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- W2947814407 doi "https://doi.org/10.1016/j.jphs.2019.05.006" @default.
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