FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947821552> ?p ?o ?g. }

• W2947821552 abstract "Abstract Non-motile primary cilia are dynamic cellular sensory structures and are expressed in adipose-derived stem cells (ASCs). We have previously shown that primary cilia are involved in chemically-induced osteogenic differentiation of human ASC (hASCs) in vitro . Further, we have reported that 10% cyclic tensile strain (1 Hz, 4 hours/day) enhances hASC osteogenesis. We hypothesize that primary cilia respond to cyclic tensile strain in a lineage dependent manner and that their mechanosensitivity may regulate the dynamics of signaling pathways localized to the cilium. We found that hASC morphology, cilia length and cilia conformation varied in response to culture in complete growth, osteogenic differentiation, or adipogenic differentiation medium, with the longest cilia expressed in adipogenically differentiating cells. Further, we show that cyclic tensile strain both enhances osteogenic differentiation of hASCs while it suppresses adipogenic differentiation as evidenced by upregulation of RUNX2 gene expression and downregulation of PPARG and IGF - 1 , respectively. This study demonstrates that hASC primary cilia exhibit mechanosensitivity to cyclic tensile strain and lineage-dependent expression, which may in part regulate signaling pathways localized to the primary cilium during the differentiation process. We highlight the importance of the primary cilium structure in mechanosensing and lineage specification and surmise that this structure may be a novel target in manipulating hASC for in tissue engineering applications." @default.
• W2947821552 created "2019-06-07" @default.
• W2947821552 creator A5014909246 @default.
• W2947821552 creator A5021576837 @default.
• W2947821552 creator A5023737852 @default.
• W2947821552 creator A5029878615 @default.
• W2947821552 creator A5044261921 @default.
• W2947821552 creator A5051430705 @default.
• W2947821552 date "2019-05-29" @default.
• W2947821552 modified "2023-10-12" @default.
• W2947821552 title "Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells" @default.
• W2947821552 cites W113532359 @default.
• W2947821552 cites W1153661258 @default.
• W2947821552 cites W1491831470 @default.
• W2947821552 cites W1538954095 @default.
• W2947821552 cites W1736787729 @default.
• W2947821552 cites W1895671929 @default.
• W2947821552 cites W1955663152 @default.
• W2947821552 cites W1967879663 @default.
• W2947821552 cites W1969024375 @default.
• W2947821552 cites W1969168731 @default.
• W2947821552 cites W1973755739 @default.
• W2947821552 cites W1973768153 @default.
• W2947821552 cites W1977166389 @default.
• W2947821552 cites W1982986056 @default.
• W2947821552 cites W1992632363 @default.
• W2947821552 cites W1995033626 @default.
• W2947821552 cites W1997763705 @default.
• W2947821552 cites W2011557260 @default.
• W2947821552 cites W2013443778 @default.
• W2947821552 cites W2017498616 @default.
• W2947821552 cites W2018435654 @default.
• W2947821552 cites W2019362387 @default.
• W2947821552 cites W2020451860 @default.
• W2947821552 cites W2027740838 @default.
• W2947821552 cites W2028607959 @default.
• W2947821552 cites W2030637965 @default.
• W2947821552 cites W2038313049 @default.
• W2947821552 cites W2041368053 @default.
• W2947821552 cites W2042429663 @default.
• W2947821552 cites W2047420544 @default.
• W2947821552 cites W2050794411 @default.
• W2947821552 cites W2055289765 @default.
• W2947821552 cites W2055993896 @default.
• W2947821552 cites W2057112611 @default.
• W2947821552 cites W2058953187 @default.
• W2947821552 cites W2059992589 @default.
• W2947821552 cites W2062329090 @default.
• W2947821552 cites W2075494055 @default.
• W2947821552 cites W2075573882 @default.
• W2947821552 cites W2078061760 @default.
• W2947821552 cites W2079380806 @default.
• W2947821552 cites W2095212309 @default.
• W2947821552 cites W2096221523 @default.
• W2947821552 cites W2100454719 @default.
• W2947821552 cites W2104440688 @default.
• W2947821552 cites W2105016447 @default.
• W2947821552 cites W2107503723 @default.
• W2947821552 cites W2108235842 @default.
• W2947821552 cites W2112591804 @default.
• W2947821552 cites W2120819121 @default.
• W2947821552 cites W2124378156 @default.
• W2947821552 cites W2124860227 @default.
• W2947821552 cites W2128933627 @default.
• W2947821552 cites W2134208433 @default.
• W2947821552 cites W2135069791 @default.
• W2947821552 cites W2142361468 @default.
• W2947821552 cites W2144023435 @default.
• W2947821552 cites W2150360143 @default.
• W2947821552 cites W2150403223 @default.
• W2947821552 cites W2164340373 @default.
• W2947821552 cites W2170692131 @default.
• W2947821552 cites W2173497140 @default.
• W2947821552 cites W2311871350 @default.
• W2947821552 cites W2336131014 @default.
• W2947821552 cites W2532322285 @default.
• W2947821552 cites W2735513135 @default.
• W2947821552 cites W2790156223 @default.
• W2947821552 cites W4249736061 @default.
• W2947821552 doi "https://doi.org/10.1038/s41598-019-43351-y" @default.
• W2947821552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6541635" @default.
• W2947821552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31142808" @default.
• W2947821552 hasPublicationYear "2019" @default.
• W2947821552 type Work @default.
• W2947821552 sameAs 2947821552 @default.
• W2947821552 citedByCount "8" @default.
• W2947821552 countsByYear W29478215522020 @default.
• W2947821552 countsByYear W29478215522021 @default.
• W2947821552 countsByYear W29478215522022 @default.
• W2947821552 countsByYear W29478215522023 @default.
• W2947821552 crossrefType "journal-article" @default.
• W2947821552 hasAuthorship W2947821552A5014909246 @default.
• W2947821552 hasAuthorship W2947821552A5021576837 @default.
• W2947821552 hasAuthorship W2947821552A5023737852 @default.
• W2947821552 hasAuthorship W2947821552A5029878615 @default.
• W2947821552 hasAuthorship W2947821552A5044261921 @default.
• W2947821552 hasAuthorship W2947821552A5051430705 @default.
• W2947821552 hasBestOaLocation W29478215521 @default.
• W2947821552 hasConcept C100094513 @default.
• W2947821552 hasConcept C104317684 @default.

• next