Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947841704> ?p ?o ?g. }
- W2947841704 endingPage "1684" @default.
- W2947841704 startingPage "1684" @default.
- W2947841704 abstract "Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus. Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories. Regulation of hippocampal neurogenesis is complex and multifaceted, and numerous signaling pathways converge to modulate cell proliferation, apoptosis, and clearance of cellular debris, as well as synaptic integration of newborn immature neurons. The expression of functional P2X7 receptors in the central nervous system has attracted much interest and the regulatory role of this purinergic receptor during adult neurogenesis has only recently begun to be explored. P2X7 receptors are exceptionally versatile: in their canonical role they act as adenosine triphosphate-gated calcium channels and facilitate calcium-signaling cascades exerting control over the cell via calcium-encoded sensory proteins and transcription factor activation. P2X7 also mediates transmembrane pore formation to regulate cytokine release and facilitate extracellular communication, and when persistently stimulated by high extracellular adenosine triphosphate levels large P2X7 pores form, which induce apoptotic cell death through cytosolic ion dysregulation. Lastly, as a scavenger receptor P2X7 directly facilitates phagocytosis of the cellular debris that arises during neurogenesis, as well as during some disease states. Understanding how P2X7 receptors regulate the physiology of stem and progenitor cells in the adult hippocampus is an important step towards developing useful therapeutic models for regenerative medicine. This review considers the relevant aspects of adult hippocampal neurogenesis and explores how P2X7 receptor activity may influence the molecular physiology of the hippocampus, and neural stem and progenitor cells." @default.
- W2947841704 created "2019-06-07" @default.
- W2947841704 creator A5001940457 @default.
- W2947841704 creator A5033083393 @default.
- W2947841704 creator A5039414225 @default.
- W2947841704 creator A5068557265 @default.
- W2947841704 creator A5077682541 @default.
- W2947841704 creator A5083371097 @default.
- W2947841704 date "2019-01-01" @default.
- W2947841704 modified "2023-10-13" @default.
- W2947841704 title "P2X7 receptor signaling during adult hippocampal neurogenesis" @default.
- W2947841704 cites W131366905 @default.
- W2947841704 cites W1485297825 @default.
- W2947841704 cites W1499468620 @default.
- W2947841704 cites W1503343518 @default.
- W2947841704 cites W1570383310 @default.
- W2947841704 cites W1574063361 @default.
- W2947841704 cites W1595178772 @default.
- W2947841704 cites W1600024584 @default.
- W2947841704 cites W1655510660 @default.
- W2947841704 cites W1857011345 @default.
- W2947841704 cites W1871335639 @default.
- W2947841704 cites W1932782160 @default.
- W2947841704 cites W1954975761 @default.
- W2947841704 cites W1964041350 @default.
- W2947841704 cites W1964136810 @default.
- W2947841704 cites W1972928390 @default.
- W2947841704 cites W1976160629 @default.
- W2947841704 cites W1979286651 @default.
- W2947841704 cites W1980006560 @default.
- W2947841704 cites W1987604172 @default.
- W2947841704 cites W1988956018 @default.
- W2947841704 cites W1988976106 @default.
- W2947841704 cites W1996024251 @default.
- W2947841704 cites W1999944391 @default.
- W2947841704 cites W2000093679 @default.
- W2947841704 cites W2000362394 @default.
- W2947841704 cites W2001915682 @default.
- W2947841704 cites W2002054197 @default.
- W2947841704 cites W2003520599 @default.
- W2947841704 cites W2007284697 @default.
- W2947841704 cites W2011489640 @default.
- W2947841704 cites W2012052743 @default.
- W2947841704 cites W2014099101 @default.
- W2947841704 cites W2018130919 @default.
- W2947841704 cites W2018231959 @default.
- W2947841704 cites W2020843402 @default.
- W2947841704 cites W2026843069 @default.
- W2947841704 cites W2028427708 @default.
- W2947841704 cites W2030038054 @default.
- W2947841704 cites W2032333518 @default.
- W2947841704 cites W2036145275 @default.
- W2947841704 cites W2036287567 @default.
- W2947841704 cites W2037758567 @default.
- W2947841704 cites W2038370680 @default.
- W2947841704 cites W2039874724 @default.
- W2947841704 cites W2041320147 @default.
- W2947841704 cites W2042065841 @default.
- W2947841704 cites W2042141743 @default.
- W2947841704 cites W2044339068 @default.
- W2947841704 cites W2045314069 @default.
- W2947841704 cites W2047962090 @default.
- W2947841704 cites W2050016412 @default.
- W2947841704 cites W2051173215 @default.
- W2947841704 cites W2051314027 @default.
- W2947841704 cites W2051449475 @default.
- W2947841704 cites W2051639780 @default.
- W2947841704 cites W2055204341 @default.
- W2947841704 cites W2058346157 @default.
- W2947841704 cites W2059137308 @default.
- W2947841704 cites W2060532219 @default.
- W2947841704 cites W2063466545 @default.
- W2947841704 cites W2065551358 @default.
- W2947841704 cites W2066784771 @default.
- W2947841704 cites W2067267561 @default.
- W2947841704 cites W2072598425 @default.
- W2947841704 cites W2074602312 @default.
- W2947841704 cites W2074764259 @default.
- W2947841704 cites W2075626955 @default.
- W2947841704 cites W2079827300 @default.
- W2947841704 cites W2082177415 @default.
- W2947841704 cites W2085678065 @default.
- W2947841704 cites W2086238867 @default.
- W2947841704 cites W2086299467 @default.
- W2947841704 cites W2089607186 @default.
- W2947841704 cites W2093495810 @default.
- W2947841704 cites W2094693149 @default.
- W2947841704 cites W2103752895 @default.
- W2947841704 cites W2111405228 @default.
- W2947841704 cites W2113805610 @default.
- W2947841704 cites W2117506912 @default.
- W2947841704 cites W2118325881 @default.
- W2947841704 cites W2120256381 @default.
- W2947841704 cites W2120811265 @default.
- W2947841704 cites W2121352124 @default.
- W2947841704 cites W2121358117 @default.
- W2947841704 cites W2132259121 @default.
- W2947841704 cites W2132958789 @default.