FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947845082> ?p ?o ?g. }

• W2947845082 abstract "Schistosomiasis is a debilitating neglected tropical disease that affects approximately 190 million people around the world. Praziquantel (PZQ) is the only drug available for use against all Schistosoma species. Although PZQ has a high efficacy, recognized concerns have prompted the development of new, alternative drugs for repeated use in endemic areas where PZQ efficacy against strains of Schistosoma is reduced. A hybrid drug containing different pharmacophores within a single molecule is a promising strategy. Our earlier in vivo studies showed the significant antiparasitic activity of a praziquantel derivative, DW-3-15, against Schistosoma japonicum. In the present study, DW-3-15 was synthesized in large amounts by a pharmaceutical company and its schistosomicidal efficacy and stability were further confirmed. Parameters such as parasite viability, pairing and oviposition were evaluated in vitro. An in vivo study was conducted to assess the effect of commercial DW-3-15 on worm burden, egg production and diameter of granulomas. Additionally, to gain insight into the mechanism of action for DW-3-15, morphological changes in the tegument of S. japonicum were also examined. The in vitro study showed the antiparasitic activity of DW-3-15 against S. japonicum, with significant reductions in viability of adult and juvenile worms, worm pairings and egg output. Compared to PZQ, DW-3-15 induced similar ultrastructural changes and evident destruction of the tegument surface in male worms. In vivo, the oral administration of DW-3-15 at a dose of 400 mg/kg per day for five consecutive days in mice significantly reduced the total worm burden and number of eggs in the liver. Histological analysis of the livers showed a marked reduction in the average diameter of the egg granuloma. Our findings suggest that DW-3-15, a PZQ derivative with the prospect of commercial production, can be developed as a potential promising schistosomicide." @default.
• W2947845082 created "2019-06-07" @default.
• W2947845082 creator A5007414392 @default.
• W2947845082 creator A5008284434 @default.
• W2947845082 creator A5017298015 @default.
• W2947845082 creator A5041339388 @default.
• W2947845082 creator A5046884970 @default.
• W2947845082 creator A5051360421 @default.
• W2947845082 creator A5058603157 @default.
• W2947845082 creator A5075871109 @default.
• W2947845082 date "2019-05-03" @default.
• W2947845082 modified "2023-09-23" @default.
• W2947845082 title "In vitro and in vivo activities of DW-3-15, a commercial praziquantel derivative, against Schistosoma japonicum" @default.
• W2947845082 cites W1574197194 @default.
• W2947845082 cites W1976170835 @default.
• W2947845082 cites W1976656705 @default.
• W2947845082 cites W1991474023 @default.
• W2947845082 cites W2002759367 @default.
• W2947845082 cites W2019443893 @default.
• W2947845082 cites W2031767509 @default.
• W2947845082 cites W2045383705 @default.
• W2947845082 cites W2050462153 @default.
• W2947845082 cites W2051635559 @default.
• W2947845082 cites W2051840067 @default.
• W2947845082 cites W2055423985 @default.
• W2947845082 cites W2059348203 @default.
• W2947845082 cites W2062791698 @default.
• W2947845082 cites W2076029682 @default.
• W2947845082 cites W2086183340 @default.
• W2947845082 cites W2091746068 @default.
• W2947845082 cites W2107152534 @default.
• W2947845082 cites W2136964048 @default.
• W2947845082 cites W2144278880 @default.
• W2947845082 cites W2145444181 @default.
• W2947845082 cites W2167306484 @default.
• W2947845082 cites W2168099287 @default.
• W2947845082 cites W2168714828 @default.
• W2947845082 cites W2175144456 @default.
• W2947845082 cites W2176070224 @default.
• W2947845082 cites W2189088983 @default.
• W2947845082 cites W2206589433 @default.
• W2947845082 cites W2216981203 @default.
• W2947845082 cites W2397518918 @default.
• W2947845082 cites W2409827135 @default.
• W2947845082 cites W2419273520 @default.
• W2947845082 cites W2511233418 @default.
• W2947845082 cites W2553328169 @default.
• W2947845082 cites W2564618243 @default.
• W2947845082 cites W2565497721 @default.
• W2947845082 cites W2594312336 @default.
• W2947845082 cites W2734565186 @default.
• W2947845082 cites W2751884637 @default.
• W2947845082 cites W2753418543 @default.
• W2947845082 cites W2792892919 @default.
• W2947845082 cites W2804577086 @default.
• W2947845082 cites W3178295071 @default.
• W2947845082 cites W4211093028 @default.
• W2947845082 cites W4211245225 @default.
• W2947845082 doi "https://doi.org/10.1186/s13071-019-3442-7" @default.
• W2947845082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6500042" @default.
• W2947845082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31053083" @default.
• W2947845082 hasPublicationYear "2019" @default.
• W2947845082 type Work @default.
• W2947845082 sameAs 2947845082 @default.
• W2947845082 citedByCount "12" @default.
• W2947845082 countsByYear W29478450822020 @default.
• W2947845082 countsByYear W29478450822021 @default.
• W2947845082 countsByYear W29478450822022 @default.
• W2947845082 countsByYear W29478450822023 @default.
• W2947845082 crossrefType "journal-article" @default.
• W2947845082 hasAuthorship W2947845082A5007414392 @default.
• W2947845082 hasAuthorship W2947845082A5008284434 @default.
• W2947845082 hasAuthorship W2947845082A5017298015 @default.
• W2947845082 hasAuthorship W2947845082A5041339388 @default.
• W2947845082 hasAuthorship W2947845082A5046884970 @default.
• W2947845082 hasAuthorship W2947845082A5051360421 @default.
• W2947845082 hasAuthorship W2947845082A5058603157 @default.
• W2947845082 hasAuthorship W2947845082A5075871109 @default.
• W2947845082 hasBestOaLocation W29478450821 @default.
• W2947845082 hasConcept C126322002 @default.
• W2947845082 hasConcept C142724271 @default.
• W2947845082 hasConcept C146998594 @default.
• W2947845082 hasConcept C150903083 @default.
• W2947845082 hasConcept C159047783 @default.
• W2947845082 hasConcept C165901193 @default.
• W2947845082 hasConcept C18903297 @default.
• W2947845082 hasConcept C190612196 @default.
• W2947845082 hasConcept C203014093 @default.
• W2947845082 hasConcept C207001950 @default.
• W2947845082 hasConcept C2776225656 @default.
• W2947845082 hasConcept C2776863245 @default.
• W2947845082 hasConcept C2776908094 @default.
• W2947845082 hasConcept C2777123769 @default.
• W2947845082 hasConcept C2777474118 @default.
• W2947845082 hasConcept C2778491710 @default.
• W2947845082 hasConcept C2779134260 @default.
• W2947845082 hasConcept C2779744950 @default.
• W2947845082 hasConcept C2781421772 @default.
• W2947845082 hasConcept C2911037157 @default.
• W2947845082 hasConcept C71924100 @default.

• next