FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947881449> ?p ?o ?g. }

• W2947881449 endingPage "e0217095" @default.
• W2947881449 startingPage "e0217095" @default.
• W2947881449 abstract "Patients with polycystic ovary syndrome (PCOS), characterized by anovulation, hyperandrogenemia and polycystic ovaries, are still vulnerable to undergo recurrent pregnancy loss and premature labor even though the ovulatory process is pharmacologically recovered. However, its potential mechanism remains unknown. Thus, our aim was to investigate the effect and mechanism of hyperandrogenemia and flutamide (a non-steroidal anti-androgen) on the embryo implantation and pregnancy during mid-pregnancy.We used a mouse model in which PCOS-like hyperandrogenemia was induced by subcutaneous injection of testosterone propionate. In this model, we observed the effect of hyperandrogenemia and flutamide on the decidualization, angiogenesis and uNK cells by methods of immunohistochemistry, quantitative PCR, western blotting and Dolichos biflorus agglutinin (DBA) lectin staining.Testosterone and flutamide treatment did not significantly influence the numbers of implanted embryo compared with the control group. However, different doses of testosterone significantly increased the ratio of resorbed /implanted embryo, decreased the level of prl8a2 mRNA and cyclin D3 protein, inhibited the uterine angiogenesis and reduced the numbers of uNK cells, but combined treatment with flutamide markedly decreased the resorbed embryos, increased expressions of prl8a2 mRNA and cyclin D3 protein and angiogenesis and numbers of uNK cells.Flutamide treatment can efficiently ameliorate the hyperandrogenemia-induced the disorders in aspects of decidualization, angiogenesis and uNK cells, which further improve the poor endometrial receptivity in PCOS patients." @default.
• W2947881449 created "2019-06-07" @default.
• W2947881449 creator A5018796206 @default.
• W2947881449 creator A5027802939 @default.
• W2947881449 creator A5029446071 @default.
• W2947881449 creator A5033808373 @default.
• W2947881449 creator A5046297997 @default.
• W2947881449 creator A5047645060 @default.
• W2947881449 creator A5047936761 @default.
• W2947881449 creator A5050582873 @default.
• W2947881449 creator A5053336135 @default.
• W2947881449 creator A5055346807 @default.
• W2947881449 date "2019-05-31" @default.
• W2947881449 modified "2023-10-12" @default.
• W2947881449 title "Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy" @default.
• W2947881449 cites W1485657849 @default.
• W2947881449 cites W1989776554 @default.
• W2947881449 cites W2010035488 @default.
• W2947881449 cites W2011137673 @default.
• W2947881449 cites W2017353776 @default.
• W2947881449 cites W2034695766 @default.
• W2947881449 cites W2042050427 @default.
• W2947881449 cites W2046480624 @default.
• W2947881449 cites W2061826324 @default.
• W2947881449 cites W2068361384 @default.
• W2947881449 cites W2078214818 @default.
• W2947881449 cites W2105404358 @default.
• W2947881449 cites W2150916795 @default.
• W2947881449 cites W2161357147 @default.
• W2947881449 cites W2166753057 @default.
• W2947881449 cites W2170048237 @default.
• W2947881449 cites W2408807646 @default.
• W2947881449 cites W2587228917 @default.
• W2947881449 cites W2596227632 @default.
• W2947881449 cites W2751797698 @default.
• W2947881449 cites W2755195123 @default.
• W2947881449 cites W2766544797 @default.
• W2947881449 cites W2801400869 @default.
• W2947881449 cites W2808333609 @default.
• W2947881449 cites W2884345651 @default.
• W2947881449 cites W289873303 @default.
• W2947881449 cites W2883874456 @default.
• W2947881449 doi "https://doi.org/10.1371/journal.pone.0217095" @default.
• W2947881449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6544220" @default.
• W2947881449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31150416" @default.
• W2947881449 hasPublicationYear "2019" @default.
• W2947881449 type Work @default.
• W2947881449 sameAs 2947881449 @default.
• W2947881449 citedByCount "18" @default.
• W2947881449 countsByYear W29478814492020 @default.
• W2947881449 countsByYear W29478814492021 @default.
• W2947881449 countsByYear W29478814492022 @default.
• W2947881449 countsByYear W29478814492023 @default.
• W2947881449 crossrefType "journal-article" @default.
• W2947881449 hasAuthorship W2947881449A5018796206 @default.
• W2947881449 hasAuthorship W2947881449A5027802939 @default.
• W2947881449 hasAuthorship W2947881449A5029446071 @default.
• W2947881449 hasAuthorship W2947881449A5033808373 @default.
• W2947881449 hasAuthorship W2947881449A5046297997 @default.
• W2947881449 hasAuthorship W2947881449A5047645060 @default.
• W2947881449 hasAuthorship W2947881449A5047936761 @default.
• W2947881449 hasAuthorship W2947881449A5050582873 @default.
• W2947881449 hasAuthorship W2947881449A5053336135 @default.
• W2947881449 hasAuthorship W2947881449A5055346807 @default.
• W2947881449 hasBestOaLocation W29478814491 @default.
• W2947881449 hasConcept C121608353 @default.
• W2947881449 hasConcept C126322002 @default.
• W2947881449 hasConcept C134018914 @default.
• W2947881449 hasConcept C16685009 @default.
• W2947881449 hasConcept C16930146 @default.
• W2947881449 hasConcept C2777391703 @default.
• W2947881449 hasConcept C2778313021 @default.
• W2947881449 hasConcept C2778316770 @default.
• W2947881449 hasConcept C2779279991 @default.
• W2947881449 hasConcept C2779306644 @default.
• W2947881449 hasConcept C2780192828 @default.
• W2947881449 hasConcept C2780394083 @default.
• W2947881449 hasConcept C3018442814 @default.
• W2947881449 hasConcept C61367390 @default.
• W2947881449 hasConcept C71924100 @default.
• W2947881449 hasConcept C86803240 @default.
• W2947881449 hasConceptScore W2947881449C121608353 @default.
• W2947881449 hasConceptScore W2947881449C126322002 @default.
• W2947881449 hasConceptScore W2947881449C134018914 @default.
• W2947881449 hasConceptScore W2947881449C16685009 @default.
• W2947881449 hasConceptScore W2947881449C16930146 @default.
• W2947881449 hasConceptScore W2947881449C2777391703 @default.
• W2947881449 hasConceptScore W2947881449C2778313021 @default.
• W2947881449 hasConceptScore W2947881449C2778316770 @default.
• W2947881449 hasConceptScore W2947881449C2779279991 @default.
• W2947881449 hasConceptScore W2947881449C2779306644 @default.
• W2947881449 hasConceptScore W2947881449C2780192828 @default.
• W2947881449 hasConceptScore W2947881449C2780394083 @default.
• W2947881449 hasConceptScore W2947881449C3018442814 @default.
• W2947881449 hasConceptScore W2947881449C61367390 @default.
• W2947881449 hasConceptScore W2947881449C71924100 @default.
• W2947881449 hasConceptScore W2947881449C86803240 @default.
• W2947881449 hasFunder F4320321001 @default.

• next