FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947881982> ?p ?o ?g. }

• W2947881982 endingPage "2065" @default.
• W2947881982 startingPage "2065" @default.
• W2947881982 abstract "Background: Acridine and thiourea derivatives are important compounds in medicinal chemistry due to their diverse biological properties including anticancer and antimicrobial effects. However, literature reveals some side effects associated with use of acridines. It is suggested that hybrid molecules may reduce the side effects and enhance the beneficial properties due to synergistic activity. The objectives of the present study are to synthesize and evaluate the anticancer and antimicrobial properties of new hybrids of acridine thiosemicarbazides derivatives. Results: The structures of the synthesized compounds 4a–4e were elucidated by MS and NMR spectra. In antimicrobial assay, Compound 4c exhibited potent antimicrobial activity compared to the other four compounds. In anticancer studies, we observed that compounds 4a, 4b, 4d and 4e exhibited high cytotoxicity against the MT-4 cell line, with IC50 values of 18.42 ± 1.18, 15.73 ± 0.90, 10.96 ± 0.62 and 11.63 ± 0.11 μM, respectively. The evaluation of anticancer effects, and the associated mechanism reveals that, the anticancer activities may be related to Topo I inhibitory activity, apoptosis and cell-cycle. Molecular docking studies revealed that the presence of planar naphtho-fused rings and a flexible thiourea group together, could improve DNA-intercalation and inhibition of DNA-Topo I activity. Conclusions: The results of this study demonstrate that the rational design of target derivatives as novel antimicrobial or antitumor leads is feasible." @default.
• W2947881982 created "2019-06-07" @default.
• W2947881982 creator A5013260103 @default.
• W2947881982 creator A5013998693 @default.
• W2947881982 creator A5021782744 @default.
• W2947881982 creator A5026320613 @default.
• W2947881982 creator A5034008248 @default.
• W2947881982 creator A5041411322 @default.
• W2947881982 creator A5054739865 @default.
• W2947881982 creator A5065782972 @default.
• W2947881982 creator A5084494795 @default.
• W2947881982 creator A5087472296 @default.
• W2947881982 date "2019-05-30" @default.
• W2947881982 modified "2023-10-16" @default.
• W2947881982 title "Design, Synthesis, Antimicrobial, and Anticancer Activities of Acridine Thiosemicarbazides Derivatives" @default.
• W2947881982 cites W1966972007 @default.
• W2947881982 cites W2007515879 @default.
• W2947881982 cites W2013285906 @default.
• W2947881982 cites W2015734461 @default.
• W2947881982 cites W2026100036 @default.
• W2947881982 cites W2036927874 @default.
• W2947881982 cites W2038257492 @default.
• W2947881982 cites W2039322158 @default.
• W2947881982 cites W2041326661 @default.
• W2947881982 cites W2044544528 @default.
• W2947881982 cites W2046330888 @default.
• W2947881982 cites W2067643889 @default.
• W2947881982 cites W2077600493 @default.
• W2947881982 cites W2081560369 @default.
• W2947881982 cites W2081994183 @default.
• W2947881982 cites W2083945212 @default.
• W2947881982 cites W2087646713 @default.
• W2947881982 cites W2123781894 @default.
• W2947881982 cites W2129553158 @default.
• W2947881982 cites W2144947872 @default.
• W2947881982 cites W2163697823 @default.
• W2947881982 cites W2172682163 @default.
• W2947881982 cites W2324278366 @default.
• W2947881982 cites W2463054001 @default.
• W2947881982 cites W2809719741 @default.
• W2947881982 cites W2951785431 @default.
• W2947881982 doi "https://doi.org/10.3390/molecules24112065" @default.
• W2947881982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6600397" @default.
• W2947881982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31151235" @default.
• W2947881982 hasPublicationYear "2019" @default.
• W2947881982 type Work @default.
• W2947881982 sameAs 2947881982 @default.
• W2947881982 citedByCount "34" @default.
• W2947881982 countsByYear W29478819822019 @default.
• W2947881982 countsByYear W29478819822020 @default.
• W2947881982 countsByYear W29478819822021 @default.
• W2947881982 countsByYear W29478819822022 @default.
• W2947881982 countsByYear W29478819822023 @default.
• W2947881982 crossrefType "journal-article" @default.
• W2947881982 hasAuthorship W2947881982A5013260103 @default.
• W2947881982 hasAuthorship W2947881982A5013998693 @default.
• W2947881982 hasAuthorship W2947881982A5021782744 @default.
• W2947881982 hasAuthorship W2947881982A5026320613 @default.
• W2947881982 hasAuthorship W2947881982A5034008248 @default.
• W2947881982 hasAuthorship W2947881982A5041411322 @default.
• W2947881982 hasAuthorship W2947881982A5054739865 @default.
• W2947881982 hasAuthorship W2947881982A5065782972 @default.
• W2947881982 hasAuthorship W2947881982A5084494795 @default.
• W2947881982 hasAuthorship W2947881982A5087472296 @default.
• W2947881982 hasBestOaLocation W29478819821 @default.
• W2947881982 hasConcept C109316439 @default.
• W2947881982 hasConcept C137824038 @default.
• W2947881982 hasConcept C178790620 @default.
• W2947881982 hasConcept C185592680 @default.
• W2947881982 hasConcept C190283241 @default.
• W2947881982 hasConcept C202751555 @default.
• W2947881982 hasConcept C21951064 @default.
• W2947881982 hasConcept C2776924795 @default.
• W2947881982 hasConcept C2779102032 @default.
• W2947881982 hasConcept C2780538656 @default.
• W2947881982 hasConcept C4937899 @default.
• W2947881982 hasConcept C55493867 @default.
• W2947881982 hasConcept C71240020 @default.
• W2947881982 hasConceptScore W2947881982C109316439 @default.
• W2947881982 hasConceptScore W2947881982C137824038 @default.
• W2947881982 hasConceptScore W2947881982C178790620 @default.
• W2947881982 hasConceptScore W2947881982C185592680 @default.
• W2947881982 hasConceptScore W2947881982C190283241 @default.
• W2947881982 hasConceptScore W2947881982C202751555 @default.
• W2947881982 hasConceptScore W2947881982C21951064 @default.
• W2947881982 hasConceptScore W2947881982C2776924795 @default.
• W2947881982 hasConceptScore W2947881982C2779102032 @default.
• W2947881982 hasConceptScore W2947881982C2780538656 @default.
• W2947881982 hasConceptScore W2947881982C4937899 @default.
• W2947881982 hasConceptScore W2947881982C55493867 @default.
• W2947881982 hasConceptScore W2947881982C71240020 @default.
• W2947881982 hasIssue "11" @default.
• W2947881982 hasLocation W29478819821 @default.
• W2947881982 hasLocation W29478819822 @default.
• W2947881982 hasLocation W29478819823 @default.
• W2947881982 hasLocation W29478819824 @default.
• W2947881982 hasOpenAccess W2947881982 @default.
• W2947881982 hasPrimaryLocation W29478819821 @default.

• next