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- W2947882741 abstract "EphA2, which belongs to the Eph family of receptor tyrosine kinases, is overexpressed in a variety of human cancers. Serine 897 (S897) phosphorylation of EphA2 is known to promote cancer cell migration and proliferation in a ligand-independent manner. In this study, we show that glucose deprivation induces S897 phosphorylation of EphA2 in glioblastoma cells. The phosphorylation requires the activity of the cystine/glutamate antiporter xCT and reactive oxygen species (ROS)-dependent ERK and RSK activation. Furthermore, depletion of EphA2 in glioblastoma cells leads to decreased cell viability under glucose starvation. Our results suggest a role of EphA2 in glioblastoma cell viability under glucose-limited conditions." @default.
- W2947882741 created "2019-06-07" @default.
- W2947882741 creator A5039215121 @default.
- W2947882741 creator A5054511414 @default.
- W2947882741 date "2019-10-01" @default.
- W2947882741 modified "2023-09-26" @default.
- W2947882741 title "The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions" @default.
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- W2947882741 doi "https://doi.org/10.1016/j.cellsig.2019.05.014" @default.
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