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- W294788314 endingPage "43" @default.
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- W294788314 abstract "Medical imaging over the last century contributed significantly in the knowledge of disease, disease mechanisms, and even in the molecular manipulation of disease with drugs and biologics. The discovery of how molecular biomarkers express, locate, change, and often drive physiologic processes has been greatly expanded using imaging. The advances in medicine from imaging have driven even more development of imaging platforms toward miniaturization for use in the nonclinical laboratory. The recent additions in the area of optical imaging with self-illuminating quantum dots (QDs), the advances in the libraries of knockout/in animal models, chemical analytical methods now applied to imaging (MALDI and SIMS-MS and MRS imaging) have made small regional in vivo sampling possible. The drug development paradigm is now shifting from the formalism of the pharmacology and toxicology paths of the last century that has served us well to a potentially revolutionary path which will reduce animal usage and obtain time rate of change of biomarker and physiologic responses to drugs and interventional strategies. This chapter is intended to be a broad overview of imaging platforms for the readers to introduce themselves into this subject matter and to come away with a new knowledge of these technologies and how they may assist in the advanced development of drug or biologics and toward regulatory approval." @default.
- W294788314 created "2016-06-24" @default.
- W294788314 creator A5085986529 @default.
- W294788314 date "2013-09-21" @default.
- W294788314 modified "2023-09-23" @default.
- W294788314 title "Imaging Platforms and Drug Development: An Introduction" @default.
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