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- W294789425 abstract "Zearalenone (ZEA), a Fusarium toxin, is frequently found in animal feed materials. It is a naturally occurring estrogenic contaminant of moldy feeds and is present in high concentrations in dairy products and cereals. Its mechanisms of toxicity involve the binding of both zearalenone and its metabolites on steroid receptors. A general detoxification process, leading to reduction of bioaccumulation of the potentially toxic substances in animal organism, is based on the bio-transformation reactions of xenobiotics catalyzed by Cytochromes P450 (CYP). CYPs are part of an enzymatic multigenetic superclass, involved in the oxidative metabolism of a great variety of molecules, such as xenobiotics (drugs, pesticides, toxins, carcinogens) and also endogenous substances (steroid hormones, fatty acids, vitamins). Our studies concern the elucidation of the effects of contaminated aliments (especially those containing Zearalenone) on the enzymes of detoxification (Cyt P450) within animal liver, particularly those involved in steroid metabolism. Another point of interest is the metabolic studies concerning the effects of zearalenone purity, alone or in natural mixtures, on CYPs expression and its animal or human pharmacokinetics. The metabolic effect of Zearalenone on the CYPs is not very well known and the previous experiments were limited to in vitro exposure. Our preliminary data are in favor of a liver CYP 1A induction upon rat i.p. treatments." @default.
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- W294789425 date "2006-01-01" @default.
- W294789425 modified "2023-09-23" @default.
- W294789425 title "Study of zearalenone contaminated feedstuffs on the detoxification enzymes." @default.
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