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• W2947902976 startingPage "1694" @default.
• W2947902976 abstract "Aflatoxin B1 (AfB1) ranks among the most potent liver carcinogens known, and the accidental or intentional exposure of humans and livestock to this toxin remains a serious global threat. One protective measure that had been proposed is employing small-molecule therapeutics capable of mitigating the toxicity of AfB1; however, to date, these efforts have had little clinical success. To identify molecular scaffolds that reduce the toxicity of AfB1, we developed a cell-based high-throughput high-content imaging assay that enabled our team to test natural products (pure compounds, fractions, and extracts) for protection of monolayers and spheroids composed of HepG2 liver cells against AfB1. The spheroid assay showed notable potential for further development, as it afforded greater sensitivity of HepG2 cells to AfB1, which is believed to better mimic the in vivo response of hepatocytes to the toxin. One of the most bioactive compounds to arise from this investigation was alternariol-9-methyl ether (1, purified from an Alternaria sp. isolate), which inspired the synthesis and testing of several structurally related molecules. Based on these findings, it is proposed that several types of natural and synthetic polyarene molecules that have undergone oxidative functionalization (e.g., compounds containing 3-methoxyphenol moieties) are promising starting points for the development of new agents that protect against AfB1 toxicity." @default.
• W2947902976 created "2019-06-07" @default.
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• W2947902976 date "2019-05-28" @default.
• W2947902976 modified "2023-09-26" @default.
• W2947902976 title "Natural-Product-Inspired Compounds as Countermeasures against the Liver Carcinogen Aflatoxin B₁" @default.
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• W2947902976 doi "https://doi.org/10.1021/acs.jnatprod.9b00290" @default.
• W2947902976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31136174" @default.
• W2947902976 hasPublicationYear "2019" @default.
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