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• W2947907527 startingPage "3011" @default.
• W2947907527 abstract "Filamentous fungi are known as prolific untapped reservoirs of diverse secondary metabolites, where genes required for their synthesis are organized in clusters. The bioactive properties of these compounds are closely related to their functions in fungal biology, which are not well understood. In this study, we focused on the Podospora anserina gene cluster responsible for the biosynthesis of sterigmatocystin (ST). Deletion of the PaStcA gene encoding the polyketide synthase and overexpression (OE) of the PaAflR gene encoding the ST-specific transcription factor in P. anserina were performed. We showed that growth of PaStcAΔ was inhibited in the presence of methylglyoxal, while OE-PaAflR showed a little inhibition, indicating that ST production may enhance oxidative stress tolerance in P. anserina. We also showed that the OE-PaAflR strain displayed an overpigmented thallus mediated by the melanin pathway. Overexpression of PaAflR also led to sterility. Interspecific confrontation assays showed that ST-overexpressed strains produced a high level of peroxides and possessed a higher competitiveness against other fungi. Comparative metabolite profiling demonstrated that PaStcAΔ strain was unable to produce ST, while OE-PaAflR displayed a ST overproduction. This study contributes to a better understanding of ST in P. anserina, especially with regard to its involvement in fungal physiology." @default.
• W2947907527 created "2019-06-07" @default.
• W2947907527 creator A5025635364 @default.
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• W2947907527 date "2019-06-19" @default.
• W2947907527 modified "2023-09-30" @default.
• W2947907527 title "Functional characterization of the sterigmatocystin secondary metabolite gene cluster in the filamentous fungus<i>Podospora anserina</i>: involvement in oxidative stress response, sexual development, pigmentation and interspecific competitions" @default.
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• W2947907527 doi "https://doi.org/10.1111/1462-2920.14698" @default.
• W2947907527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31136075" @default.
• W2947907527 hasPublicationYear "2019" @default.
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