Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947927520> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2947927520 abstract "e23105 Background: Although cisplatin-based chemotherapy has been the mainstay in the treatment of advanced non-small cell lung cancer (NSCLC), it is still controversial as to whether furosemide (FUR) or mannitol (MAN) is better as a forced diuresis for avoiding cisplatin-induced nephrotoxicity. We conducted a randomized phase II trial to clarify this issue in candidates. Methods: Those with advanced NSCLC, suitable for receiving cisplatin-based chemotherapy with an adequate renal function were randomly assigned either to the FUR arm or the MAN arm. Either of forced diuretics was administered with an appropriate hydration in cisplatin administration. The primary endpoint of the study was a proportion of ≥ grade 1 serum Creatinine (Cr) elevation in the first cycle, defined by the CTCAE v4.0. Results: The trial was terminated early with 44 (FUR arm; 22 and MAN arm; 22) of the planned 66 patients because of slow accrual. The patient demographics are listed in Table1. In the first cycle, 2 (9%) and 4 patients (18%) developed grade 1 Cr elevation, respectively (P = 0.33), despite no ≥ grade 2 toxicity. The median time to develop the worst Cr score was 29 (range: 26-31) and 12 (range: 8-28) days, respectively. All patients recovered within 3 to 330 days, respectively. Cisplatin induced grade 3 emesis was observed in 3 patients (14%) in MAN arm, whilst none developed in FUR arm. No treatment related deaths were observed. Conclusions: In this setting, the preventive effect of the two types of forced diuretics on cisplatin-induced renal toxicity was not significantly different. Clinical trial information: UMIN000015293. [Table: see text]" @default.
- W2947927520 created "2019-06-07" @default.
- W2947927520 creator A5002407044 @default.
- W2947927520 creator A5014194149 @default.
- W2947927520 creator A5019511958 @default.
- W2947927520 creator A5025889209 @default.
- W2947927520 creator A5036685872 @default.
- W2947927520 creator A5039723911 @default.
- W2947927520 creator A5050389295 @default.
- W2947927520 creator A5056975051 @default.
- W2947927520 creator A5061557628 @default.
- W2947927520 creator A5062920555 @default.
- W2947927520 creator A5066700160 @default.
- W2947927520 creator A5084024353 @default.
- W2947927520 date "2019-05-20" @default.
- W2947927520 modified "2023-09-23" @default.
- W2947927520 title "Randomized phase II study comparing mannitol with furosemide for the prevention of cisplatin-induced renal toxicity in advanced non-small cell lung cancer: The OLCSG1406 trial." @default.
- W2947927520 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.e23105" @default.
- W2947927520 hasPublicationYear "2019" @default.
- W2947927520 type Work @default.
- W2947927520 sameAs 2947927520 @default.
- W2947927520 citedByCount "1" @default.
- W2947927520 countsByYear W29479275202021 @default.
- W2947927520 crossrefType "journal-article" @default.
- W2947927520 hasAuthorship W2947927520A5002407044 @default.
- W2947927520 hasAuthorship W2947927520A5014194149 @default.
- W2947927520 hasAuthorship W2947927520A5019511958 @default.
- W2947927520 hasAuthorship W2947927520A5025889209 @default.
- W2947927520 hasAuthorship W2947927520A5036685872 @default.
- W2947927520 hasAuthorship W2947927520A5039723911 @default.
- W2947927520 hasAuthorship W2947927520A5050389295 @default.
- W2947927520 hasAuthorship W2947927520A5056975051 @default.
- W2947927520 hasAuthorship W2947927520A5061557628 @default.
- W2947927520 hasAuthorship W2947927520A5062920555 @default.
- W2947927520 hasAuthorship W2947927520A5066700160 @default.
- W2947927520 hasAuthorship W2947927520A5084024353 @default.
- W2947927520 hasConcept C126322002 @default.
- W2947927520 hasConcept C143998085 @default.
- W2947927520 hasConcept C168563851 @default.
- W2947927520 hasConcept C178790620 @default.
- W2947927520 hasConcept C185592680 @default.
- W2947927520 hasConcept C2776256026 @default.
- W2947927520 hasConcept C2776694085 @default.
- W2947927520 hasConcept C2777955127 @default.
- W2947927520 hasConcept C2778239845 @default.
- W2947927520 hasConcept C2778445172 @default.
- W2947927520 hasConcept C29730261 @default.
- W2947927520 hasConcept C71924100 @default.
- W2947927520 hasConcept C98274493 @default.
- W2947927520 hasConceptScore W2947927520C126322002 @default.
- W2947927520 hasConceptScore W2947927520C143998085 @default.
- W2947927520 hasConceptScore W2947927520C168563851 @default.
- W2947927520 hasConceptScore W2947927520C178790620 @default.
- W2947927520 hasConceptScore W2947927520C185592680 @default.
- W2947927520 hasConceptScore W2947927520C2776256026 @default.
- W2947927520 hasConceptScore W2947927520C2776694085 @default.
- W2947927520 hasConceptScore W2947927520C2777955127 @default.
- W2947927520 hasConceptScore W2947927520C2778239845 @default.
- W2947927520 hasConceptScore W2947927520C2778445172 @default.
- W2947927520 hasConceptScore W2947927520C29730261 @default.
- W2947927520 hasConceptScore W2947927520C71924100 @default.
- W2947927520 hasConceptScore W2947927520C98274493 @default.
- W2947927520 hasLocation W29479275201 @default.
- W2947927520 hasOpenAccess W2947927520 @default.
- W2947927520 hasPrimaryLocation W29479275201 @default.
- W2947927520 isParatext "false" @default.
- W2947927520 isRetracted "false" @default.
- W2947927520 magId "2947927520" @default.
- W2947927520 workType "article" @default.