Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947933080> ?p ?o ?g. }
- W2947933080 endingPage "311" @default.
- W2947933080 startingPage "298" @default.
- W2947933080 abstract "Microglia play a key role in innate immunity in Alzheimer disease (AD), but their role as antigen-presenting cells is as yet unclear. Here we found that amyloid β peptide (Aβ)-specific T helper 1 (Aβ-Th1 cells) T cells polarized to secrete interferon-γ and intracerebroventricularly (ICV) injected to the 5XFAD mouse model of AD induced the differentiation of major histocompatibility complex class II (MHCII)+ microglia with distinct morphology and enhanced plaque clearance capacity than MHCII- microglia. Notably, 5XFAD mice lacking MHCII exhibited an enhanced amyloid pathology in the brain along with exacerbated innate inflammation and reduced phagocytic capacity. Using a bone marrow chimera mouse model, we showed that infiltrating macrophages did not differentiate to MHCII+ cells following ICV injection of Aβ-Th1 cells and did not support T cell-mediated amyloid clearance. Overall, we demonstrate that CD4 T cells induce a P2ry12+ MHCII+ subset of microglia, which play a key role in T cell-mediated effector functions that abrogate AD-like pathology." @default.
- W2947933080 created "2019-06-07" @default.
- W2947933080 creator A5001471959 @default.
- W2947933080 creator A5005650464 @default.
- W2947933080 creator A5006589325 @default.
- W2947933080 creator A5015221915 @default.
- W2947933080 creator A5021684394 @default.
- W2947933080 creator A5041616817 @default.
- W2947933080 creator A5068911152 @default.
- W2947933080 creator A5082141287 @default.
- W2947933080 creator A5085382687 @default.
- W2947933080 date "2019-06-01" @default.
- W2947933080 modified "2023-10-18" @default.
- W2947933080 title "CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology" @default.
- W2947933080 cites W1541951511 @default.
- W2947933080 cites W1667616536 @default.
- W2947933080 cites W1755136173 @default.
- W2947933080 cites W1820592927 @default.
- W2947933080 cites W1947372322 @default.
- W2947933080 cites W1965397995 @default.
- W2947933080 cites W1967399741 @default.
- W2947933080 cites W1973664335 @default.
- W2947933080 cites W1984644447 @default.
- W2947933080 cites W1990428105 @default.
- W2947933080 cites W1992481658 @default.
- W2947933080 cites W1993682245 @default.
- W2947933080 cites W1999499766 @default.
- W2947933080 cites W2001618696 @default.
- W2947933080 cites W2004349171 @default.
- W2947933080 cites W2011041653 @default.
- W2947933080 cites W2018546175 @default.
- W2947933080 cites W2041690090 @default.
- W2947933080 cites W2045282691 @default.
- W2947933080 cites W2050267226 @default.
- W2947933080 cites W2063664365 @default.
- W2947933080 cites W2066792703 @default.
- W2947933080 cites W2070847731 @default.
- W2947933080 cites W2074274825 @default.
- W2947933080 cites W2082423050 @default.
- W2947933080 cites W2087243986 @default.
- W2947933080 cites W2098889184 @default.
- W2947933080 cites W2103428562 @default.
- W2947933080 cites W2107376426 @default.
- W2947933080 cites W2116063788 @default.
- W2947933080 cites W2116369972 @default.
- W2947933080 cites W2124836944 @default.
- W2947933080 cites W2127148071 @default.
- W2947933080 cites W2145679714 @default.
- W2947933080 cites W2157648547 @default.
- W2947933080 cites W2159103481 @default.
- W2947933080 cites W2165863447 @default.
- W2947933080 cites W2166732068 @default.
- W2947933080 cites W2170644095 @default.
- W2947933080 cites W2172092273 @default.
- W2947933080 cites W2172251692 @default.
- W2947933080 cites W2189621653 @default.
- W2947933080 cites W2200279205 @default.
- W2947933080 cites W2257167523 @default.
- W2947933080 cites W2271499489 @default.
- W2947933080 cites W2275744255 @default.
- W2947933080 cites W2285980052 @default.
- W2947933080 cites W2329336071 @default.
- W2947933080 cites W2339534121 @default.
- W2947933080 cites W2416355123 @default.
- W2947933080 cites W2418940280 @default.
- W2947933080 cites W2468319471 @default.
- W2947933080 cites W2504925882 @default.
- W2947933080 cites W2539358755 @default.
- W2947933080 cites W2542427033 @default.
- W2947933080 cites W2554361415 @default.
- W2947933080 cites W2570663248 @default.
- W2947933080 cites W2600475754 @default.
- W2947933080 cites W2601638375 @default.
- W2947933080 cites W2606059203 @default.
- W2947933080 cites W2608110367 @default.
- W2947933080 cites W2622807556 @default.
- W2947933080 cites W2626924766 @default.
- W2947933080 cites W2638382976 @default.
- W2947933080 cites W2744890984 @default.
- W2947933080 cites W2754887039 @default.
- W2947933080 cites W2761726094 @default.
- W2947933080 cites W2768892314 @default.
- W2947933080 cites W2771554318 @default.
- W2947933080 cites W2775503072 @default.
- W2947933080 cites W2784431956 @default.
- W2947933080 cites W2909270098 @default.
- W2947933080 cites W2911407981 @default.
- W2947933080 cites W2918315099 @default.
- W2947933080 cites W2941510527 @default.
- W2947933080 cites W4210981518 @default.
- W2947933080 cites W4252526962 @default.
- W2947933080 doi "https://doi.org/10.1016/j.isci.2019.05.039" @default.
- W2947933080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6581663" @default.
- W2947933080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31203186" @default.
- W2947933080 hasPublicationYear "2019" @default.
- W2947933080 type Work @default.
- W2947933080 sameAs 2947933080 @default.
- W2947933080 citedByCount "49" @default.