Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947957415> ?p ?o ?g. }
- W2947957415 endingPage "2708" @default.
- W2947957415 startingPage "2708" @default.
- W2947957415 abstract "M. avium subsp. paratuberculosis (MAP) is the causative pathogen of Johne's disease, a chronic granulomatous enteritis that principally affects ruminants and can survive, proliferate and disseminate in macrophages. MicroRNAs (miRNAs) are important regulators of gene expression and can impact the processes of cells. To investigate the role of miRNAs in monocyte-derived macrophages (MDMs) during MAP infection, we used high-throughput sequencing technology to analyze small RNA libraries of MAP-infected and control MDMs. The results showed that a total of 21 miRNAs were differentially expressed in MDMs after MAP infection, and 8864 target genes were predicted. A functional analysis showed that the target genes were mainly involved in the MAPK signaling pathway, Toll-like receptor signaling pathway, NF-kappa B signaling pathway and apoptosis. In addition, using a dual-luciferase reporter assay, flow cytometry, and a small interfering (si)RNA knockdown assay, the role of miR-150 in regulating macrophage apoptosis by targeting the programmed cell death protein-4 (PDCD4) was demonstrated. These results provide an experimental basis to reveal the regulatory mechanism of MAP infection and suggest the potential of miRNAs as biomarkers for the diagnosis of Johne's disease in bovines." @default.
- W2947957415 created "2019-06-07" @default.
- W2947957415 creator A5013555971 @default.
- W2947957415 creator A5021235960 @default.
- W2947957415 creator A5022222545 @default.
- W2947957415 creator A5035556864 @default.
- W2947957415 creator A5053666308 @default.
- W2947957415 creator A5064776202 @default.
- W2947957415 creator A5076742045 @default.
- W2947957415 date "2019-06-01" @default.
- W2947957415 modified "2023-09-27" @default.
- W2947957415 title "Analysis of the microRNA Expression Profile of Bovine Monocyte-derived Macrophages Infected with Mycobacterium avium subsp. Paratuberculosis Reveals that miR-150 Suppresses Cell Apoptosis by Targeting PDCD4" @default.
- W2947957415 cites W1463226234 @default.
- W2947957415 cites W1502698740 @default.
- W2947957415 cites W1596082116 @default.
- W2947957415 cites W1885174764 @default.
- W2947957415 cites W1967798195 @default.
- W2947957415 cites W1976180663 @default.
- W2947957415 cites W1986243847 @default.
- W2947957415 cites W1995291683 @default.
- W2947957415 cites W1996056056 @default.
- W2947957415 cites W1998018670 @default.
- W2947957415 cites W2006831423 @default.
- W2947957415 cites W2013869704 @default.
- W2947957415 cites W2017570593 @default.
- W2947957415 cites W2025454477 @default.
- W2947957415 cites W2029962149 @default.
- W2947957415 cites W2030166934 @default.
- W2947957415 cites W2047330514 @default.
- W2947957415 cites W2048178760 @default.
- W2947957415 cites W2051207923 @default.
- W2947957415 cites W2074245007 @default.
- W2947957415 cites W2074862238 @default.
- W2947957415 cites W2085696170 @default.
- W2947957415 cites W2100039643 @default.
- W2947957415 cites W2100334598 @default.
- W2947957415 cites W2102122219 @default.
- W2947957415 cites W2112615055 @default.
- W2947957415 cites W2122222163 @default.
- W2947957415 cites W2122575917 @default.
- W2947957415 cites W2123679324 @default.
- W2947957415 cites W2124957695 @default.
- W2947957415 cites W2125172467 @default.
- W2947957415 cites W2125945390 @default.
- W2947957415 cites W2135216005 @default.
- W2947957415 cites W2138442694 @default.
- W2947957415 cites W2140150226 @default.
- W2947957415 cites W2148186218 @default.
- W2947957415 cites W2155679588 @default.
- W2947957415 cites W2155682692 @default.
- W2947957415 cites W2162674813 @default.
- W2947957415 cites W2164616601 @default.
- W2947957415 cites W2167840222 @default.
- W2947957415 cites W2169538397 @default.
- W2947957415 cites W2171488801 @default.
- W2947957415 cites W2276538703 @default.
- W2947957415 cites W2289162037 @default.
- W2947957415 cites W2339074003 @default.
- W2947957415 cites W2516987737 @default.
- W2947957415 cites W2538629671 @default.
- W2947957415 cites W2555909205 @default.
- W2947957415 cites W2579946198 @default.
- W2947957415 cites W2604156990 @default.
- W2947957415 cites W2770431539 @default.
- W2947957415 cites W2788482851 @default.
- W2947957415 cites W2795251701 @default.
- W2947957415 cites W2804590262 @default.
- W2947957415 cites W2804969145 @default.
- W2947957415 cites W2886046598 @default.
- W2947957415 cites W2912668499 @default.
- W2947957415 doi "https://doi.org/10.3390/ijms20112708" @default.
- W2947957415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6600136" @default.
- W2947957415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31159463" @default.
- W2947957415 hasPublicationYear "2019" @default.
- W2947957415 type Work @default.
- W2947957415 sameAs 2947957415 @default.
- W2947957415 citedByCount "12" @default.
- W2947957415 countsByYear W29479574152020 @default.
- W2947957415 countsByYear W29479574152021 @default.
- W2947957415 countsByYear W29479574152022 @default.
- W2947957415 countsByYear W29479574152023 @default.
- W2947957415 crossrefType "journal-article" @default.
- W2947957415 hasAuthorship W2947957415A5013555971 @default.
- W2947957415 hasAuthorship W2947957415A5021235960 @default.
- W2947957415 hasAuthorship W2947957415A5022222545 @default.
- W2947957415 hasAuthorship W2947957415A5035556864 @default.
- W2947957415 hasAuthorship W2947957415A5053666308 @default.
- W2947957415 hasAuthorship W2947957415A5064776202 @default.
- W2947957415 hasAuthorship W2947957415A5076742045 @default.
- W2947957415 hasBestOaLocation W29479574151 @default.
- W2947957415 hasConcept C104317684 @default.
- W2947957415 hasConcept C145059251 @default.
- W2947957415 hasConcept C153911025 @default.
- W2947957415 hasConcept C173396325 @default.
- W2947957415 hasConcept C190283241 @default.
- W2947957415 hasConcept C22615655 @default.
- W2947957415 hasConcept C2777849792 @default.
- W2947957415 hasConcept C2780374374 @default.