FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947963805> ?p ?o ?g. }

• W2947963805 abstract "Myocardial infarction (MI) is a common cause of chronic heart failure (HF). Increasing evidence has revealed that trimethylamine N‑oxide (TMAO), a gut‑microbiota‑derived metabolite, contributes to the pathogenesis of cardiovascular disease by promoting inflammation. Elevated levels of circulating TMAO have been reported in patients following MI and were associated with unfavorable outcomes. The present study examined whether reductions in circulating TMAO could attenuate the progression of HF in rats following MI. Sprague‑Dawley rats underwent coronary ligation to induce MI or a sham operation. Echocardiography confirmed MI and cardiac dysfunction one day following coronary ligation. MI and sham rats were then treated with either vehicle (tap water) or 1.0% 3,3‑dimethyl‑1‑butanol (DMB, a trimethylamine formation inhibitor) in tap water, for 8 weeks. At the end of the experiment, TMAO plasma levels were markedly elevated in vehicle‑treated MI rats compared with vehicle‑treated sham rats; however, TMAO plasma levels were reduced in DMB‑treated MI rats compared with vehicle‑treated MI rats. Both MI groups exhibited cardiac hypertrophy, lung congestion, left ventricular remodeling and impaired cardiac function, according to the results of anatomical analysis, echocardiography and left ventricular hemodynamics; however, these manifestations of MI‑induced HF were significantly improved in DMB‑treated MI rats compared with vehicle‑treated MI rats. The plasma levels of the chemokine interleukin (IL)‑8, and cardiac expression of IL‑8 and its receptors were significantly increased in vehicle‑treated MI rats compared with vehicle‑treated sham rats; however, these were normalized in DMB‑treated MI rats. In addition, elevated TMAO plasma level was positively correlated with increased IL‑8 plasma level in MI groups. Notably, DMB treatment of sham rats also reduced plasma TMAO, but did not alter other parameters. These results indicated that reducing circulating TMAO may ameliorate the development of chronic HF following MI in rats, potentially by inhibiting IL‑8 secretion. The results from the present study suggested that inhibition of TMAO synthesis may be considered as a novel therapeutic approach for the prevention and treatment of patients with chronic MI‑induced HF." @default.
• W2947963805 created "2019-06-07" @default.
• W2947963805 creator A5037677450 @default.
• W2947963805 creator A5049376285 @default.
• W2947963805 creator A5089079624 @default.
• W2947963805 creator A5090269955 @default.
• W2947963805 date "2019-05-27" @default.
• W2947963805 modified "2023-10-14" @default.
• W2947963805 title "Reductions in gut microbiota‑derived metabolite trimethylamine N‑oxide in the circulation may ameliorate myocardial infarction‑induced heart failure in rats, possibly by inhibiting interleukin‑8 secretion" @default.
• W2947963805 cites W2023012224 @default.
• W2947963805 cites W2061343675 @default.
• W2947963805 cites W2101140397 @default.
• W2947963805 cites W2108423180 @default.
• W2947963805 cites W2112568641 @default.
• W2947963805 cites W2118024623 @default.
• W2947963805 cites W2125212020 @default.
• W2947963805 cites W2126318057 @default.
• W2947963805 cites W2207436601 @default.
• W2947963805 cites W2276935317 @default.
• W2947963805 cites W2282801396 @default.
• W2947963805 cites W2343539326 @default.
• W2947963805 cites W2391191430 @default.
• W2947963805 cites W2467675381 @default.
• W2947963805 cites W2548611371 @default.
• W2947963805 cites W2551397368 @default.
• W2947963805 cites W2556034984 @default.
• W2947963805 cites W2556415826 @default.
• W2947963805 cites W2598218405 @default.
• W2947963805 cites W2608753124 @default.
• W2947963805 cites W2617058021 @default.
• W2947963805 cites W2745455453 @default.
• W2947963805 cites W2769636409 @default.
• W2947963805 cites W2784568242 @default.
• W2947963805 cites W2788255593 @default.
• W2947963805 cites W2794439438 @default.
• W2947963805 cites W2810050135 @default.
• W2947963805 cites W2884566703 @default.
• W2947963805 cites W2885593516 @default.
• W2947963805 doi "https://doi.org/10.3892/mmr.2019.10297" @default.
• W2947963805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31180562" @default.
• W2947963805 hasPublicationYear "2019" @default.
• W2947963805 type Work @default.
• W2947963805 sameAs 2947963805 @default.
• W2947963805 citedByCount "8" @default.
• W2947963805 countsByYear W29479638052019 @default.
• W2947963805 countsByYear W29479638052020 @default.
• W2947963805 countsByYear W29479638052021 @default.
• W2947963805 countsByYear W29479638052023 @default.
• W2947963805 crossrefType "journal-article" @default.
• W2947963805 hasAuthorship W2947963805A5037677450 @default.
• W2947963805 hasAuthorship W2947963805A5049376285 @default.
• W2947963805 hasAuthorship W2947963805A5089079624 @default.
• W2947963805 hasAuthorship W2947963805A5090269955 @default.
• W2947963805 hasBestOaLocation W29479638051 @default.
• W2947963805 hasConcept C111566952 @default.
• W2947963805 hasConcept C126322002 @default.
• W2947963805 hasConcept C134018914 @default.
• W2947963805 hasConcept C164705383 @default.
• W2947963805 hasConcept C185592680 @default.
• W2947963805 hasConcept C2776149385 @default.
• W2947963805 hasConcept C2776914184 @default.
• W2947963805 hasConcept C2778198053 @default.
• W2947963805 hasConcept C2778921608 @default.
• W2947963805 hasConcept C2779376020 @default.
• W2947963805 hasConcept C2780924926 @default.
• W2947963805 hasConcept C500558357 @default.
• W2947963805 hasConcept C55493867 @default.
• W2947963805 hasConcept C71924100 @default.
• W2947963805 hasConceptScore W2947963805C111566952 @default.
• W2947963805 hasConceptScore W2947963805C126322002 @default.
• W2947963805 hasConceptScore W2947963805C134018914 @default.
• W2947963805 hasConceptScore W2947963805C164705383 @default.
• W2947963805 hasConceptScore W2947963805C185592680 @default.
• W2947963805 hasConceptScore W2947963805C2776149385 @default.
• W2947963805 hasConceptScore W2947963805C2776914184 @default.
• W2947963805 hasConceptScore W2947963805C2778198053 @default.
• W2947963805 hasConceptScore W2947963805C2778921608 @default.
• W2947963805 hasConceptScore W2947963805C2779376020 @default.
• W2947963805 hasConceptScore W2947963805C2780924926 @default.
• W2947963805 hasConceptScore W2947963805C500558357 @default.
• W2947963805 hasConceptScore W2947963805C55493867 @default.
• W2947963805 hasConceptScore W2947963805C71924100 @default.
• W2947963805 hasLocation W29479638051 @default.
• W2947963805 hasLocation W29479638052 @default.
• W2947963805 hasOpenAccess W2947963805 @default.
• W2947963805 hasPrimaryLocation W29479638051 @default.
• W2947963805 hasRelatedWork W109966298 @default.
• W2947963805 hasRelatedWork W1864361583 @default.
• W2947963805 hasRelatedWork W2049397185 @default.
• W2947963805 hasRelatedWork W2125804349 @default.
• W2947963805 hasRelatedWork W2127666157 @default.
• W2947963805 hasRelatedWork W2155913505 @default.
• W2947963805 hasRelatedWork W2369841220 @default.
• W2947963805 hasRelatedWork W2399063111 @default.
• W2947963805 hasRelatedWork W2999308310 @default.
• W2947963805 hasRelatedWork W3201311221 @default.
• W2947963805 isParatext "false" @default.
• W2947963805 isRetracted "false" @default.
• W2947963805 magId "2947963805" @default.
• W2947963805 workType "article" @default.