Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947994674> ?p ?o ?g. }
- W2947994674 endingPage "41" @default.
- W2947994674 startingPage "27" @default.
- W2947994674 abstract "Glial cells, such as astrocytes and microglia, contribute to maintain tissue homeostasis in the brain and are involved in the control of neuronal function, synaptic plasticity, and neuroinflammation. In the aged brain and under neurodegenerative conditions, microglial cells acquire a senescent reactive phenotype, which involves a dysregulated inflammatory response that affects the normal function and metabolism of neurons and other cell types, including astrocytes. The impaired function of astrocytes and microglia in the aged brain increases neuroinflammation, which is associated with depressive disorders and cognitive deficits. Estradiol, from gonadal origin or locally produced in the brain, exerts anti-inflammatory actions in the central nervous system, regulating the reactive phenotype of astrocytes and microglia. In addition, estrogen receptor signaling exerts direct neuroprotective actions on neurons and interacts with the signaling of other neuroprotective and anti-inflammatory factors in the brain. These actions of estradiol and estrogen receptors contribute to maintain a proper neuronal information processing, promoting cognitive function and preventing affective disorders. The effects of estradiol are imitated by synthetic estrogenic compounds, such as some selective estrogen receptor modulators and tibolone." @default.
- W2947994674 created "2019-06-07" @default.
- W2947994674 creator A5055935408 @default.
- W2947994674 creator A5057589065 @default.
- W2947994674 creator A5064375891 @default.
- W2947994674 creator A5075093230 @default.
- W2947994674 creator A5083968750 @default.
- W2947994674 date "2019-01-01" @default.
- W2947994674 modified "2023-10-04" @default.
- W2947994674 title "Estrogenic Regulation of Neuroprotective and Neuroinflammatory Mechanisms: Implications for Depression and Cognition" @default.
- W2947994674 cites W1001344463 @default.
- W2947994674 cites W1029300765 @default.
- W2947994674 cites W1200438078 @default.
- W2947994674 cites W1493890929 @default.
- W2947994674 cites W1502673994 @default.
- W2947994674 cites W1511964200 @default.
- W2947994674 cites W1519245788 @default.
- W2947994674 cites W1551831696 @default.
- W2947994674 cites W175348630 @default.
- W2947994674 cites W1802303241 @default.
- W2947994674 cites W1834923160 @default.
- W2947994674 cites W1858755391 @default.
- W2947994674 cites W1965442168 @default.
- W2947994674 cites W1965674437 @default.
- W2947994674 cites W1969474756 @default.
- W2947994674 cites W1970146816 @default.
- W2947994674 cites W1970558743 @default.
- W2947994674 cites W1971210170 @default.
- W2947994674 cites W1973563466 @default.
- W2947994674 cites W1973762720 @default.
- W2947994674 cites W1978633381 @default.
- W2947994674 cites W1982708468 @default.
- W2947994674 cites W1982864010 @default.
- W2947994674 cites W1983376582 @default.
- W2947994674 cites W1985438873 @default.
- W2947994674 cites W1987037769 @default.
- W2947994674 cites W1987742395 @default.
- W2947994674 cites W1991599211 @default.
- W2947994674 cites W1995997452 @default.
- W2947994674 cites W1998006367 @default.
- W2947994674 cites W2001236923 @default.
- W2947994674 cites W2002452662 @default.
- W2947994674 cites W2003704824 @default.
- W2947994674 cites W2004904601 @default.
- W2947994674 cites W2009670662 @default.
- W2947994674 cites W2012632172 @default.
- W2947994674 cites W2015705124 @default.
- W2947994674 cites W2017639299 @default.
- W2947994674 cites W2023667812 @default.
- W2947994674 cites W2025590886 @default.
- W2947994674 cites W2027368264 @default.
- W2947994674 cites W2030727754 @default.
- W2947994674 cites W2034134656 @default.
- W2947994674 cites W2035709546 @default.
- W2947994674 cites W2036095353 @default.
- W2947994674 cites W2036831472 @default.
- W2947994674 cites W2037305368 @default.
- W2947994674 cites W2037460676 @default.
- W2947994674 cites W2040042755 @default.
- W2947994674 cites W2041683554 @default.
- W2947994674 cites W2041910867 @default.
- W2947994674 cites W2043709248 @default.
- W2947994674 cites W2044032827 @default.
- W2947994674 cites W2048741943 @default.
- W2947994674 cites W2050133476 @default.
- W2947994674 cites W2056220196 @default.
- W2947994674 cites W2056484778 @default.
- W2947994674 cites W2059810727 @default.
- W2947994674 cites W2060968640 @default.
- W2947994674 cites W2062790940 @default.
- W2947994674 cites W2066870378 @default.
- W2947994674 cites W2074807166 @default.
- W2947994674 cites W2075294017 @default.
- W2947994674 cites W2084207276 @default.
- W2947994674 cites W2085918017 @default.
- W2947994674 cites W2086376642 @default.
- W2947994674 cites W2086974237 @default.
- W2947994674 cites W2087878009 @default.
- W2947994674 cites W2088037571 @default.
- W2947994674 cites W2088101528 @default.
- W2947994674 cites W2088763858 @default.
- W2947994674 cites W2089406620 @default.
- W2947994674 cites W2093181833 @default.
- W2947994674 cites W2093334643 @default.
- W2947994674 cites W2096064131 @default.
- W2947994674 cites W2101261343 @default.
- W2947994674 cites W2101503056 @default.
- W2947994674 cites W2104366862 @default.
- W2947994674 cites W2105404306 @default.
- W2947994674 cites W2126795224 @default.
- W2947994674 cites W2128916701 @default.
- W2947994674 cites W2136855986 @default.
- W2947994674 cites W2140019947 @default.
- W2947994674 cites W2140542140 @default.
- W2947994674 cites W2144001897 @default.
- W2947994674 cites W2148219292 @default.
- W2947994674 cites W2148574879 @default.
- W2947994674 cites W2151576808 @default.