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- W2947996890 abstract "Abstract Background In this work, peptide based antiglycation agents from various sources against the advanced glycation endproducts (AGE) formation was investigated. Materials and methods As a source of peptides with deglycating activity, Glycine max , Hordeum vulgare , Triticum aestivum , Avena sativa , Prunus dulcis ve Juglans regia were used. The metal chelating activity and antioxidant activity were determined by Cu(II) chelating activity and CUPRAC (Cupric Reducing Antioxidant Capacity) methods. Antidiabetic activity was evaluated through BSA-glucose model. Results Most of the extracts obtained have inhibitory activity against AGE formation. Among all plant peptide isolates soybean was found to be most efficient by means of antiglycating (IC50 1.33 μg/mL), antioxidant (28.2 ± 1.4 μmol AAE/mg) and metal chelation activity (55%). Conclusion As a result, this study can provide preliminary data to literature to support researches those focused on peptide based glycation inhibitors and discovery of potent AGE inhibitory peptides." @default.
- W2947996890 created "2019-06-07" @default.
- W2947996890 creator A5008320507 @default.
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- W2947996890 date "2019-05-27" @default.
- W2947996890 modified "2023-10-02" @default.
- W2947996890 title "Investigation and isolation of peptide based antiglycating agents from various sources" @default.
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- W2947996890 doi "https://doi.org/10.1515/tjb-2018-0294" @default.
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