FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947998908> ?p ?o ?g. }

• W2947998908 endingPage "7431" @default.
• W2947998908 startingPage "7419" @default.
• W2947998908 abstract "Contamination of soils and sediments with the highly persistent hexachlorocyclohexanes (HCHs) continues to be a threat for humans and the environment. Despite the existence of bacteria capable of biodegradation and cometabolic transformation of HCH isomers, such processes occur over time scales of decades and are thus challenging to assess. Here, we explored the use of compound-specific isotope analysis (CSIA) to track the aerobic biodegradation and biotransformation pathways of the most prominent isomers, namely, (-)-α-, (+)-α-, β-, γ-, and δ-HCH, through changes of their C and H isotope composition in assays of LinA2 and LinB enzymes. Dehydrochlorination of (+)-α-, γ-, and δ-HCH catalyzed by LinA2 was subject to substantial C and H isotope fraction with apparent 13C- and 2H-kinetic isotope effects (AKIEs) of up to 1.029 ± 0.001 and 6.7 ± 2.9, respectively, which are indicative of bimolecular eliminations. Hydrolytic dechlorination of δ-HCH by LinB exhibited even larger C but substantially smaller H isotope fractionation with 13C- and 2H-AKIEs of 1.073 ± 0.006 and 1.41 ± 0.04, respectively, which are typical for nucleophilic substitutions. The systematic evaluation of isomer-specific phenomena showed that, in addition to contaminant uptake limitations, diffusion-limited turnover ((-)-α-HCH), substrate dissolution (β-HCH), and potentially competing reactions catalyzed by constitutively expressed enzymes might bias the assessment of HCH biodegradation by CSIA at contaminated sites." @default.
• W2947998908 created "2019-06-07" @default.
• W2947998908 creator A5033056846 @default.
• W2947998908 creator A5045330091 @default.
• W2947998908 creator A5047952289 @default.
• W2947998908 creator A5056151397 @default.
• W2947998908 creator A5049744891 @default.
• W2947998908 date "2019-05-27" @default.
• W2947998908 modified "2023-09-23" @default.
• W2947998908 title "Assessing Aerobic Biotransformation of Hexachlorocyclohexane Isomers by Compound-Specific Isotope Analysis" @default.
• W2947998908 cites W1578329775 @default.
• W2947998908 cites W1898688056 @default.
• W2947998908 cites W1906324884 @default.
• W2947998908 cites W1980312426 @default.
• W2947998908 cites W1983209599 @default.
• W2947998908 cites W1990802403 @default.
• W2947998908 cites W1991672477 @default.
• W2947998908 cites W1992208564 @default.
• W2947998908 cites W1999967582 @default.
• W2947998908 cites W2001114346 @default.
• W2947998908 cites W2003905228 @default.
• W2947998908 cites W2004748396 @default.
• W2947998908 cites W2007154846 @default.
• W2947998908 cites W2013884547 @default.
• W2947998908 cites W2021250937 @default.
• W2947998908 cites W2023133133 @default.
• W2947998908 cites W2023285390 @default.
• W2947998908 cites W2024534259 @default.
• W2947998908 cites W2036138475 @default.
• W2947998908 cites W2038843785 @default.
• W2947998908 cites W2041964295 @default.
• W2947998908 cites W2043192665 @default.
• W2947998908 cites W2045490589 @default.
• W2947998908 cites W2046223217 @default.
• W2947998908 cites W2046272501 @default.
• W2947998908 cites W2047175685 @default.
• W2947998908 cites W2048269953 @default.
• W2947998908 cites W2064773720 @default.
• W2947998908 cites W2073969385 @default.
• W2947998908 cites W2075417540 @default.
• W2947998908 cites W2078365254 @default.
• W2947998908 cites W2085390258 @default.
• W2947998908 cites W2092025745 @default.
• W2947998908 cites W2094476414 @default.
• W2947998908 cites W2095677518 @default.
• W2947998908 cites W2097529558 @default.
• W2947998908 cites W2102653059 @default.
• W2947998908 cites W2106562928 @default.
• W2947998908 cites W2108077038 @default.
• W2947998908 cites W2111639786 @default.
• W2947998908 cites W2115032262 @default.
• W2947998908 cites W2133307836 @default.
• W2947998908 cites W2135642153 @default.
• W2947998908 cites W2136895820 @default.
• W2947998908 cites W2139562530 @default.
• W2947998908 cites W2142040022 @default.
• W2947998908 cites W2147533449 @default.
• W2947998908 cites W2192116867 @default.
• W2947998908 cites W2210176953 @default.
• W2947998908 cites W2291674210 @default.
• W2947998908 cites W2312346766 @default.
• W2947998908 cites W2314143596 @default.
• W2947998908 cites W2314296790 @default.
• W2947998908 cites W2316538092 @default.
• W2947998908 cites W2343121367 @default.
• W2947998908 cites W2346516012 @default.
• W2947998908 cites W2593823830 @default.
• W2947998908 cites W2605331367 @default.
• W2947998908 cites W2732090513 @default.
• W2947998908 cites W2750061068 @default.
• W2947998908 cites W2768699046 @default.
• W2947998908 cites W2783716976 @default.
• W2947998908 cites W2914351680 @default.
• W2947998908 cites W2915562588 @default.
• W2947998908 doi "https://doi.org/10.1021/acs.est.9b01007" @default.
• W2947998908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31132243" @default.
• W2947998908 hasPublicationYear "2019" @default.
• W2947998908 type Work @default.
• W2947998908 sameAs 2947998908 @default.
• W2947998908 citedByCount "17" @default.
• W2947998908 countsByYear W29479989082019 @default.
• W2947998908 countsByYear W29479989082020 @default.
• W2947998908 countsByYear W29479989082021 @default.
• W2947998908 countsByYear W29479989082022 @default.
• W2947998908 countsByYear W29479989082023 @default.
• W2947998908 crossrefType "journal-article" @default.
• W2947998908 hasAuthorship W2947998908A5033056846 @default.
• W2947998908 hasAuthorship W2947998908A5045330091 @default.
• W2947998908 hasAuthorship W2947998908A5047952289 @default.
• W2947998908 hasAuthorship W2947998908A5049744891 @default.
• W2947998908 hasAuthorship W2947998908A5056151397 @default.
• W2947998908 hasBestOaLocation W29479989082 @default.
• W2947998908 hasConcept C107872376 @default.
• W2947998908 hasConcept C121332964 @default.
• W2947998908 hasConcept C157021035 @default.
• W2947998908 hasConcept C161176658 @default.
• W2947998908 hasConcept C178790620 @default.
• W2947998908 hasConcept C181199279 @default.

• next