Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948006680> ?p ?o ?g. }
- W2948006680 endingPage "372" @default.
- W2948006680 startingPage "362" @default.
- W2948006680 abstract "Abstract Dilated cardiomyopathy ( DCM ) is characterized by left ventricular dilatation and, consecutively, contractile dysfunction. The causes of DCM are heterogeneous. DCM often results from myocarditis, exposure to alcohol, drugs or other toxins and metabolic or endocrine disturbances. In about 35% of patients, genetic mutations can be identified that usually involve genes responsible for cytoskeletal, sarcomere and nuclear envelope proteins. Due to its heterogeneity, a detailed diagnostic work‐up is necessary to identify the specific underlying cause and exclude other conditions with phenotype overlap. Patients with DCM show typical systolic heart failure symptoms, but, with progress of the disease, diastolic dysfunction is present as well. Depending on the underlying pathology, DCM patients also become apparent through arrhythmias, thromboembolic events or cardiogenic shock. Disease progression and prognosis are mostly driven by disease severity and reverse remodelling within the heart. The worst prognosis is seen in patients with lowest ejection fractions or severe diastolic dysfunction, leading to terminal heart failure with subsequent need for left ventricular assist device implantation or heart transplantation. Guideline‐based heart failure medication and device therapy reduces the frequency of heart failure hospitalizations and improves survival." @default.
- W2948006680 created "2019-06-07" @default.
- W2948006680 creator A5022312846 @default.
- W2948006680 creator A5030454575 @default.
- W2948006680 creator A5046127730 @default.
- W2948006680 creator A5088612562 @default.
- W2948006680 date "2019-07-29" @default.
- W2948006680 modified "2023-10-14" @default.
- W2948006680 title "Dilated cardiomyopathy: from epidemiologic to genetic phenotypes" @default.
- W2948006680 cites W1195941168 @default.
- W2948006680 cites W1741371889 @default.
- W2948006680 cites W1967799621 @default.
- W2948006680 cites W1968816076 @default.
- W2948006680 cites W1970098795 @default.
- W2948006680 cites W1970953541 @default.
- W2948006680 cites W1974550968 @default.
- W2948006680 cites W1974959278 @default.
- W2948006680 cites W1975836528 @default.
- W2948006680 cites W1977184882 @default.
- W2948006680 cites W1977325015 @default.
- W2948006680 cites W1978953141 @default.
- W2948006680 cites W1982778219 @default.
- W2948006680 cites W1983466715 @default.
- W2948006680 cites W1987902037 @default.
- W2948006680 cites W1991507611 @default.
- W2948006680 cites W1993492475 @default.
- W2948006680 cites W1994243834 @default.
- W2948006680 cites W1994426704 @default.
- W2948006680 cites W2001045428 @default.
- W2948006680 cites W2001580684 @default.
- W2948006680 cites W2005673278 @default.
- W2948006680 cites W2011112539 @default.
- W2948006680 cites W2014086287 @default.
- W2948006680 cites W2017839586 @default.
- W2948006680 cites W2023046355 @default.
- W2948006680 cites W2026628004 @default.
- W2948006680 cites W2028305954 @default.
- W2948006680 cites W2029654767 @default.
- W2948006680 cites W2032002843 @default.
- W2948006680 cites W2032724298 @default.
- W2948006680 cites W2035667813 @default.
- W2948006680 cites W2043659211 @default.
- W2948006680 cites W2045143786 @default.
- W2948006680 cites W2046194099 @default.
- W2948006680 cites W2050370911 @default.
- W2948006680 cites W2059104750 @default.
- W2948006680 cites W2060017281 @default.
- W2948006680 cites W2061892272 @default.
- W2948006680 cites W2063329561 @default.
- W2948006680 cites W2066501944 @default.
- W2948006680 cites W2067453366 @default.
- W2948006680 cites W2073111593 @default.
- W2948006680 cites W2076936029 @default.
- W2948006680 cites W2078904330 @default.
- W2948006680 cites W2080625632 @default.
- W2948006680 cites W2091583677 @default.
- W2948006680 cites W2091831926 @default.
- W2948006680 cites W2113565284 @default.
- W2948006680 cites W2113698123 @default.
- W2948006680 cites W2116091611 @default.
- W2948006680 cites W2116351152 @default.
- W2948006680 cites W2133332900 @default.
- W2948006680 cites W2139331439 @default.
- W2948006680 cites W2146521529 @default.
- W2948006680 cites W2146665756 @default.
- W2948006680 cites W2153281463 @default.
- W2948006680 cites W2161777080 @default.
- W2948006680 cites W2167989424 @default.
- W2948006680 cites W2169010419 @default.
- W2948006680 cites W2171759754 @default.
- W2948006680 cites W2171905803 @default.
- W2948006680 cites W2237393579 @default.
- W2948006680 cites W2256541296 @default.
- W2948006680 cites W2329687194 @default.
- W2948006680 cites W2462777565 @default.
- W2948006680 cites W2464496825 @default.
- W2948006680 cites W2477171588 @default.
- W2948006680 cites W2548775624 @default.
- W2948006680 cites W2556701428 @default.
- W2948006680 cites W2602925775 @default.
- W2948006680 cites W2607210228 @default.
- W2948006680 cites W2734930111 @default.
- W2948006680 cites W2735499937 @default.
- W2948006680 cites W2755193453 @default.
- W2948006680 cites W2755887165 @default.
- W2948006680 cites W2770331207 @default.
- W2948006680 cites W2793094728 @default.
- W2948006680 cites W2794126000 @default.
- W2948006680 cites W2899617144 @default.
- W2948006680 cites W2900687357 @default.
- W2948006680 cites W2921472519 @default.
- W2948006680 cites W33013791 @default.
- W2948006680 cites W4210974985 @default.
- W2948006680 cites W4211157269 @default.
- W2948006680 cites W4231978856 @default.
- W2948006680 cites W4233172062 @default.
- W2948006680 cites W4233977448 @default.
- W2948006680 cites W4238376026 @default.