FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948064926> ?p ?o ?g. }

• W2948064926 endingPage "9085" @default.
• W2948064926 startingPage "9078" @default.
• W2948064926 abstract "Glycan head-groups attached to glycosphingolipids (GSLs) found in the cell membrane bilayer can alter in response to external stimuli and disease, making them potential markers and/or targets for cellular disease states. To identify such markers, comprehensive analyses of glycan structures must be undertaken. Conventional analyses of fluorescently labeled glycans using hydrophilic interaction high-performance liquid chromatography (HILIC) coupled with mass spectrometry (MS) provides relative quantitation and has the ability to perform automated glycan assignments using glucose unit (GU) and mass matching. The use of ion mobility (IM) as an additional level of separation can aid the characterization of closely related or isomeric structures through the generation of glycan collision cross section (CCS) identifiers. Here, we present a workflow for the analysis of procainamide-labeled GSL glycans using HILIC-IM-MS and a new, automated glycan identification strategy whereby multiple glycan attributes are combined to increase accuracy in automated structural assignments. For glycan matching and identification, an experimental reference database of GSL glycans containing GU, mass, and CCS values for each glycan was created. To assess the accuracy of glycan assignments, a distance-based confidence metric was used. The assignment accuracy was significantly better compared to conventional HILIC-MS approaches (using mass and GU only). This workflow was applied to the study of two Triple Negative Breast Cancer (TNBC) cell lines and revealed potential GSL glycosylation signatures characteristic of different TNBC subtypes." @default.
• W2948064926 created "2019-06-14" @default.
• W2948064926 creator A5011421634 @default.
• W2948064926 creator A5017996022 @default.
• W2948064926 creator A5030961377 @default.
• W2948064926 creator A5045092193 @default.
• W2948064926 creator A5058304991 @default.
• W2948064926 creator A5060625212 @default.
• W2948064926 creator A5064775072 @default.
• W2948064926 creator A5076422141 @default.
• W2948064926 creator A5077652709 @default.
• W2948064926 creator A5082734561 @default.
• W2948064926 creator A5084854649 @default.
• W2948064926 date "2019-06-09" @default.
• W2948064926 modified "2023-10-18" @default.
• W2948064926 title "Combining Glucose Units, <i>m</i>/<i>z</i>, and Collision Cross Section Values: Multiattribute Data for Increased Accuracy in Automated Glycosphingolipid Glycan Identifications and Its Application in Triple Negative Breast Cancer" @default.
• W2948064926 cites W1518310590 @default.
• W2948064926 cites W1600141098 @default.
• W2948064926 cites W1753095474 @default.
• W2948064926 cites W1895025345 @default.
• W2948064926 cites W1963521654 @default.
• W2948064926 cites W1968014420 @default.
• W2948064926 cites W1970792779 @default.
• W2948064926 cites W1986508522 @default.
• W2948064926 cites W2005343690 @default.
• W2948064926 cites W2025060953 @default.
• W2948064926 cites W2054970390 @default.
• W2948064926 cites W2067845342 @default.
• W2948064926 cites W2102236335 @default.
• W2948064926 cites W2110971595 @default.
• W2948064926 cites W2122879447 @default.
• W2948064926 cites W2134539328 @default.
• W2948064926 cites W2147483959 @default.
• W2948064926 cites W2156759982 @default.
• W2948064926 cites W2158519314 @default.
• W2948064926 cites W2164405704 @default.
• W2948064926 cites W2267724599 @default.
• W2948064926 cites W2335438498 @default.
• W2948064926 cites W2507561431 @default.
• W2948064926 cites W2563935489 @default.
• W2948064926 cites W2597467486 @default.
• W2948064926 cites W2598497411 @default.
• W2948064926 cites W2601187649 @default.
• W2948064926 cites W2602271431 @default.
• W2948064926 cites W2621637707 @default.
• W2948064926 cites W2802734758 @default.
• W2948064926 cites W952517265 @default.
• W2948064926 doi "https://doi.org/10.1021/acs.analchem.9b01476" @default.
• W2948064926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31179689" @default.
• W2948064926 hasPublicationYear "2019" @default.
• W2948064926 type Work @default.
• W2948064926 sameAs 2948064926 @default.
• W2948064926 citedByCount "12" @default.
• W2948064926 countsByYear W29480649262020 @default.
• W2948064926 countsByYear W29480649262021 @default.
• W2948064926 countsByYear W29480649262022 @default.
• W2948064926 countsByYear W29480649262023 @default.
• W2948064926 crossrefType "journal-article" @default.
• W2948064926 hasAuthorship W2948064926A5011421634 @default.
• W2948064926 hasAuthorship W2948064926A5017996022 @default.
• W2948064926 hasAuthorship W2948064926A5030961377 @default.
• W2948064926 hasAuthorship W2948064926A5045092193 @default.
• W2948064926 hasAuthorship W2948064926A5058304991 @default.
• W2948064926 hasAuthorship W2948064926A5060625212 @default.
• W2948064926 hasAuthorship W2948064926A5064775072 @default.
• W2948064926 hasAuthorship W2948064926A5076422141 @default.
• W2948064926 hasAuthorship W2948064926A5077652709 @default.
• W2948064926 hasAuthorship W2948064926A5082734561 @default.
• W2948064926 hasAuthorship W2948064926A5084854649 @default.
• W2948064926 hasConcept C108625454 @default.
• W2948064926 hasConcept C116817701 @default.
• W2948064926 hasConcept C162356407 @default.
• W2948064926 hasConcept C179998833 @default.
• W2948064926 hasConcept C185592680 @default.
• W2948064926 hasConcept C206212055 @default.
• W2948064926 hasConcept C2776931407 @default.
• W2948064926 hasConcept C2777313579 @default.
• W2948064926 hasConcept C43617362 @default.
• W2948064926 hasConcept C55493867 @default.
• W2948064926 hasConcept C70721500 @default.
• W2948064926 hasConcept C86803240 @default.
• W2948064926 hasConceptScore W2948064926C108625454 @default.
• W2948064926 hasConceptScore W2948064926C116817701 @default.
• W2948064926 hasConceptScore W2948064926C162356407 @default.
• W2948064926 hasConceptScore W2948064926C179998833 @default.
• W2948064926 hasConceptScore W2948064926C185592680 @default.
• W2948064926 hasConceptScore W2948064926C206212055 @default.
• W2948064926 hasConceptScore W2948064926C2776931407 @default.
• W2948064926 hasConceptScore W2948064926C2777313579 @default.
• W2948064926 hasConceptScore W2948064926C43617362 @default.
• W2948064926 hasConceptScore W2948064926C55493867 @default.
• W2948064926 hasConceptScore W2948064926C70721500 @default.
• W2948064926 hasConceptScore W2948064926C86803240 @default.
• W2948064926 hasFunder F4320320696 @default.
• W2948064926 hasIssue "14" @default.
• W2948064926 hasLocation W29480649261 @default.
• W2948064926 hasLocation W29480649262 @default.
• W2948064926 hasOpenAccess W2948064926 @default.

• next