Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948068137> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2948068137 abstract "Background The thyroid hormone (TH) plays an important role in glucose metabolism. Recently, we showed that the TH improves glycemia control by decreasing cytokines expression in the adipose tissue and skeletal muscle of alloxan-induced diabetic rats, which were also shown to present primary hypothyroidism. In this context, this study aims to investigate whether the chronic treatment of diabetic rats with T3 could affect other tissues that are involved in the control of glucose homeostasis, as the liver and kidney. Methods Adult male Wistar rats were divided into nondiabetic, diabetic, and diabetic treated with T3 (1.5 μg/100 g BW for 4 weeks). Diabetes was induced by alloxan monohydrate (150 mg/kg, BW, i.p.). Animals showing fasting blood glucose levels greater than 250 mg/dL were selected for the study. Results After treatment, we measured the blood glucose, serum T3, T4, TSH, and insulin concentration, hepatic glucose production by liver perfusion, liver PEPCK, GAPDH, and pAKT expression, as well as urine glucose concentration and renal expression of SGLT2 and GLUT2. T3 reduced blood glucose, hepatic glucose production, liver PEPCK, GAPDH, and pAKT content and the renal expression of SGLT2 and increased glycosuria. Conclusions Results suggest that the decreased hepatic glucose output and increased glucose excretion induced by T3 treatment are important mechanisms that contribute to reducing serum concentration of glucose, accounting for the improvement of glucose homeostasis control in diabetic rats." @default.
- W2948068137 created "2019-06-14" @default.
- W2948068137 creator A5049399782 @default.
- W2948068137 date "2019-06-01" @default.
- W2948068137 modified "2023-09-24" @default.
- W2948068137 title "IDDF2019-ABS-0266 Effects of thyroid hormone treatment on hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic wistar rats" @default.
- W2948068137 doi "https://doi.org/10.1136/gutjnl-2019-iddfabstracts.106" @default.
- W2948068137 hasPublicationYear "2019" @default.
- W2948068137 type Work @default.
- W2948068137 sameAs 2948068137 @default.
- W2948068137 citedByCount "0" @default.
- W2948068137 crossrefType "proceedings-article" @default.
- W2948068137 hasAuthorship W2948068137A5049399782 @default.
- W2948068137 hasBestOaLocation W29480681371 @default.
- W2948068137 hasConcept C126322002 @default.
- W2948068137 hasConcept C134018914 @default.
- W2948068137 hasConcept C161573976 @default.
- W2948068137 hasConcept C17093226 @default.
- W2948068137 hasConcept C2777180221 @default.
- W2948068137 hasConcept C2777391703 @default.
- W2948068137 hasConcept C2777901630 @default.
- W2948068137 hasConcept C2779306644 @default.
- W2948068137 hasConcept C2780091579 @default.
- W2948068137 hasConcept C2781005915 @default.
- W2948068137 hasConcept C2781214132 @default.
- W2948068137 hasConcept C3018667095 @default.
- W2948068137 hasConcept C555293320 @default.
- W2948068137 hasConcept C63645605 @default.
- W2948068137 hasConcept C71924100 @default.
- W2948068137 hasConcept C90466245 @default.
- W2948068137 hasConceptScore W2948068137C126322002 @default.
- W2948068137 hasConceptScore W2948068137C134018914 @default.
- W2948068137 hasConceptScore W2948068137C161573976 @default.
- W2948068137 hasConceptScore W2948068137C17093226 @default.
- W2948068137 hasConceptScore W2948068137C2777180221 @default.
- W2948068137 hasConceptScore W2948068137C2777391703 @default.
- W2948068137 hasConceptScore W2948068137C2777901630 @default.
- W2948068137 hasConceptScore W2948068137C2779306644 @default.
- W2948068137 hasConceptScore W2948068137C2780091579 @default.
- W2948068137 hasConceptScore W2948068137C2781005915 @default.
- W2948068137 hasConceptScore W2948068137C2781214132 @default.
- W2948068137 hasConceptScore W2948068137C3018667095 @default.
- W2948068137 hasConceptScore W2948068137C555293320 @default.
- W2948068137 hasConceptScore W2948068137C63645605 @default.
- W2948068137 hasConceptScore W2948068137C71924100 @default.
- W2948068137 hasConceptScore W2948068137C90466245 @default.
- W2948068137 hasLocation W29480681371 @default.
- W2948068137 hasOpenAccess W2948068137 @default.
- W2948068137 hasPrimaryLocation W29480681371 @default.
- W2948068137 hasRelatedWork W1981548969 @default.
- W2948068137 hasRelatedWork W1994667169 @default.
- W2948068137 hasRelatedWork W2012249194 @default.
- W2948068137 hasRelatedWork W2014508254 @default.
- W2948068137 hasRelatedWork W2017903081 @default.
- W2948068137 hasRelatedWork W2023056644 @default.
- W2948068137 hasRelatedWork W2043905814 @default.
- W2948068137 hasRelatedWork W2046728637 @default.
- W2948068137 hasRelatedWork W2052233528 @default.
- W2948068137 hasRelatedWork W2076111847 @default.
- W2948068137 hasRelatedWork W2099623630 @default.
- W2948068137 hasRelatedWork W2156093747 @default.
- W2948068137 hasRelatedWork W2160041008 @default.
- W2948068137 hasRelatedWork W2277107211 @default.
- W2948068137 hasRelatedWork W2344606627 @default.
- W2948068137 hasRelatedWork W2380998645 @default.
- W2948068137 hasRelatedWork W2381792387 @default.
- W2948068137 hasRelatedWork W2796951034 @default.
- W2948068137 hasRelatedWork W70930828 @default.
- W2948068137 hasRelatedWork W2182817039 @default.
- W2948068137 isParatext "false" @default.
- W2948068137 isRetracted "false" @default.
- W2948068137 magId "2948068137" @default.
- W2948068137 workType "article" @default.