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- W2948105504 endingPage "240.e7" @default.
- W2948105504 startingPage "225" @default.
- W2948105504 abstract "The specific cellular physiology of hematopoietic stem cells (HSCs) is underexplored, and their maintenance in vitro remains challenging. We discovered that culture of HSCs in low calcium increased their maintenance as determined by phenotype, function, and single-cell expression signature. HSCs are endowed with low intracellular calcium conveyed by elevated activity of glycolysis-fueled plasma membrane calcium efflux pumps and a low-bone-marrow interstitial fluid calcium concentration. Low-calcium conditions inhibited calpain proteases, which target ten-eleven translocated (TET) enzymes, of which TET2 was required for the effect of low calcium conditions on HSC maintenance in vitro. These observations reveal a physiological feature of HSCs that can be harnessed to improve their maintenance in vitro." @default.
- W2948105504 created "2019-06-14" @default.
- W2948105504 creator A5010521304 @default.
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- W2948105504 creator A5053166204 @default.
- W2948105504 creator A5061151796 @default.
- W2948105504 creator A5083128585 @default.
- W2948105504 date "2019-08-01" @default.
- W2948105504 modified "2023-10-17" @default.
- W2948105504 title "Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro" @default.
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