Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948156973> ?p ?o ?g. }
- W2948156973 abstract "β3-Adrenoceptors couple not only to cAMP formation but, at least in some cell types, also to alternative signaling pathways such as phosphorylation of extracellular signal-regulated kinase (ERK). β3-Adrenoceptor agonists are used in long-term symptomatic treatment of the overactive bladder syndrome; it is only poorly understood which signaling pathway mediates the clinical response and whether it undergoes agonist-induced desensitization. Therefore, we used human embryonic kidney cells stably transfected with human β3-adrenoceptors to compare coupling of ligands with various degrees of efficacy, including biased agonists, to cAMP formation and ERK phosphorylation, particularly regarding desensitization. Ligands stimulated cAMP formation with a numerical rank order of isoprenaline ≥ L 755,507 ≥ CL 316,243 > solabegron > SR 59,230 > L 748,337. Except for the weakest agonist, L 748,337, pre-treatment with any ligand reduced cAMP responses to freshly added isoprenaline or forskolin to a similar extent. On the other hand, we were unable to detect ERK phosphorylation despite testing a wide variation of conditions. We conclude that a minor degree of efficacy for cAMP formation may be sufficient to induced full desensitization of that response. Transfected human embryonic kidney cells are not suitable to study desensitization of ERK phosphorylation by β3-adrenoceptor stimulation." @default.
- W2948156973 created "2019-06-14" @default.
- W2948156973 creator A5020683373 @default.
- W2948156973 creator A5063515847 @default.
- W2948156973 creator A5074129005 @default.
- W2948156973 date "2019-06-07" @default.
- W2948156973 modified "2023-10-01" @default.
- W2948156973 title "Desensitization of cAMP Accumulation via Human β3-Adrenoceptors Expressed in Human Embryonic Kidney Cells by Full, Partial, and Biased Agonists" @default.
- W2948156973 cites W1548131418 @default.
- W2948156973 cites W1787320721 @default.
- W2948156973 cites W1932343077 @default.
- W2948156973 cites W1968429293 @default.
- W2948156973 cites W1970114251 @default.
- W2948156973 cites W1971024460 @default.
- W2948156973 cites W1977690609 @default.
- W2948156973 cites W1978275113 @default.
- W2948156973 cites W1978960070 @default.
- W2948156973 cites W1981917249 @default.
- W2948156973 cites W1985689558 @default.
- W2948156973 cites W1994969848 @default.
- W2948156973 cites W1997481591 @default.
- W2948156973 cites W2002896923 @default.
- W2948156973 cites W2003234447 @default.
- W2948156973 cites W2007359597 @default.
- W2948156973 cites W2010447474 @default.
- W2948156973 cites W2016458036 @default.
- W2948156973 cites W2018430156 @default.
- W2948156973 cites W2022169135 @default.
- W2948156973 cites W2026137267 @default.
- W2948156973 cites W2026716308 @default.
- W2948156973 cites W2039272248 @default.
- W2948156973 cites W2039673170 @default.
- W2948156973 cites W2046234877 @default.
- W2948156973 cites W2061005244 @default.
- W2948156973 cites W2063082171 @default.
- W2948156973 cites W2073603771 @default.
- W2948156973 cites W2078543261 @default.
- W2948156973 cites W2078721878 @default.
- W2948156973 cites W2080104381 @default.
- W2948156973 cites W2087237522 @default.
- W2948156973 cites W2088812635 @default.
- W2948156973 cites W2089290218 @default.
- W2948156973 cites W2098104423 @default.
- W2948156973 cites W2107153432 @default.
- W2948156973 cites W2112387528 @default.
- W2948156973 cites W2114393684 @default.
- W2948156973 cites W2129930339 @default.
- W2948156973 cites W2142569325 @default.
- W2948156973 cites W2147220948 @default.
- W2948156973 cites W2153727440 @default.
- W2948156973 cites W2154939993 @default.
- W2948156973 cites W2159960984 @default.
- W2948156973 cites W2161321211 @default.
- W2948156973 cites W2167373815 @default.
- W2948156973 cites W2169016904 @default.
- W2948156973 cites W2261817895 @default.
- W2948156973 cites W2275842453 @default.
- W2948156973 cites W2276390905 @default.
- W2948156973 cites W2293793121 @default.
- W2948156973 cites W2336864235 @default.
- W2948156973 cites W2409835869 @default.
- W2948156973 cites W2611662169 @default.
- W2948156973 cites W2784783440 @default.
- W2948156973 cites W2917831885 @default.
- W2948156973 cites W322030742 @default.
- W2948156973 cites W4240996555 @default.
- W2948156973 cites W4248096658 @default.
- W2948156973 cites W2414998541 @default.
- W2948156973 doi "https://doi.org/10.3389/fphar.2019.00596" @default.
- W2948156973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6590479" @default.
- W2948156973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31263412" @default.
- W2948156973 hasPublicationYear "2019" @default.
- W2948156973 type Work @default.
- W2948156973 sameAs 2948156973 @default.
- W2948156973 citedByCount "7" @default.
- W2948156973 countsByYear W29481569732019 @default.
- W2948156973 countsByYear W29481569732020 @default.
- W2948156973 countsByYear W29481569732021 @default.
- W2948156973 crossrefType "journal-article" @default.
- W2948156973 hasAuthorship W2948156973A5020683373 @default.
- W2948156973 hasAuthorship W2948156973A5063515847 @default.
- W2948156973 hasAuthorship W2948156973A5074129005 @default.
- W2948156973 hasBestOaLocation W29481569731 @default.
- W2948156973 hasConcept C11960822 @default.
- W2948156973 hasConcept C126322002 @default.
- W2948156973 hasConcept C134018914 @default.
- W2948156973 hasConcept C170493617 @default.
- W2948156973 hasConcept C174510640 @default.
- W2948156973 hasConcept C184235292 @default.
- W2948156973 hasConcept C185592680 @default.
- W2948156973 hasConcept C24998067 @default.
- W2948156973 hasConcept C2776090920 @default.
- W2948156973 hasConcept C2778938600 @default.
- W2948156973 hasConcept C2779276759 @default.
- W2948156973 hasConcept C2779779143 @default.
- W2948156973 hasConcept C57074206 @default.
- W2948156973 hasConcept C62478195 @default.
- W2948156973 hasConcept C71924100 @default.
- W2948156973 hasConcept C86803240 @default.
- W2948156973 hasConcept C92759361 @default.