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- W2948183417 abstract "Stroke and traumatic brain injury (TBI) are the major causes of adult long-term disability worldwide. Unfortunately, there are no efficacious therapies available for the vast majority of stroke and TBI patients during their convalescence. As a thrombolytic agent, recombinant tissue plasminogen activator (tPA) is the only FDA approved therapeutic agent for treatment of acute ischemic stroke; however, the application of tPA is limited by the narrow therapeutic time window and potential adverse side effects on brain edema and hemorrhage. In addition to vascular endothelium derived tPA in the circulation, neuroendocrine tissue synthesized tPA is widely distributed in the CNS and is involved in axonal path finding, synaptic plasticity and dendritic remodeling during development, and axonal outgrowth after stroke and injury. We have investigated the therapeutic effect of tPA on neurological recovery and corticospinal axonal remodeling in rodent subacute stroke and TBI models administered intranasally, to bypass the blood-brain barrier and avoid the rapid inactivation and clearance of tPA in the circulation. The neurorestorative benefits of tPA in subacute stroke and TBI treatments and the potential underlying mechanisms are discussed in this chapter." @default.
- W2948183417 created "2019-06-14" @default.
- W2948183417 creator A5005508444 @default.
- W2948183417 creator A5011056392 @default.
- W2948183417 creator A5024838548 @default.
- W2948183417 date "2019-01-01" @default.
- W2948183417 modified "2023-09-27" @default.
- W2948183417 title "Intranasal tPA Application for Axonal Remodeling in Rodent Stroke and Traumatic Brain Injury Models" @default.
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