Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948223141> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2948223141 abstract "Introduction: Neuroischemic (NI) diabetic foot (DF) is an advanced complication leading to limb amputations and cardiac mortality. We contributed to demonstrate that bone marrow (BM) T2D neuropathy impairs vascular regenerative hematopoietic cell mobilization. We here hypothesize that autonomic neuropathy (DAN) and pathological orthostatic hypotension (reducing systolic and diastolic blood pressure -BP at least 30 and 10 mm Hg) convert to cardiovascular death in T2D patients with NI-DF. Subjects and Methods: We performed DAN and postural hypotension tests in 204 surgical-treated neuropathic T2D without (87 N) or with (117 NI) critical limb ischemia (pO2 <30 mm Hg). In peripheral blood (PB) (204) and BM (65) samples we evaluated: percentage of haematopoietic precursor CD34+, VEGF receptor KDR+ (PreC) and neurokinin-1 receptor on BM-CD34+ cells (BM-NK1R+preC) by flow cytometry; circulating P substance neuropeptide by ELISA. Results: We observed 46 NI cardiac deaths (DD) and 158 alive patients (AD) after prospective 5 years. DD were older but comparable for diabetes age, BMI, HbA1c, post-revascularization oximetry and TUC lesion grade. All T2D had autonomic failure but only DD were orthostatically hypotensive (-BP -35±2 and -21± 3 mm Hg p<0.01 vs. AD) with different BM/PB preC incremental ratio (8.8±4 vs. 1.5 ±0.3 106 events p<0.0003 vs. AD), similar circulating P levels, reduced BM-NK1R+preC (14.5±8.5 vs. 36.4±5 % p<0.04). Both -BP correlate with BM/PB preC (p< 0.04) but not with BM-NK1R+preC. Conclusions: We prospectively confirm that autonomic failure impacts on vascular homeostasis and cardiac mortality in T2D with prevalent NI-DF. Now we demonstrate that pathological orthostatic hypotension, a simple clinical measure, could contribute to persistent ischemic bone marrow signal in neuroreceptor reduced BM-derived stem cells, worsening BM vascular regenerative capacity and cardiac performance. Disclosure M. Sambataro: None. L. Sambado: None. G. Spinetti: None. E. Seganfreddo: None. E. Trevisiol: None. M. Marcon: None. P. Stefani: None. A. Furlan: None. M. Cacciatore: None. A. Paccagnella: None. Funding Italian Diabetic Patients' Association of Treviso and Oderzo" @default.
- W2948223141 created "2019-06-14" @default.
- W2948223141 creator A5000726438 @default.
- W2948223141 creator A5010863889 @default.
- W2948223141 creator A5020202301 @default.
- W2948223141 creator A5030107487 @default.
- W2948223141 creator A5041605390 @default.
- W2948223141 creator A5073971614 @default.
- W2948223141 creator A5074094118 @default.
- W2948223141 creator A5079026709 @default.
- W2948223141 creator A5079827760 @default.
- W2948223141 creator A5090631931 @default.
- W2948223141 date "2019-06-01" @default.
- W2948223141 modified "2023-10-17" @default.
- W2948223141 title "621-P: Cardiovascular Mortality and Orthostatic Hypotension in Type 2 Diabetic Patients (T2D) with Lower Limb Lesions—Italian Diabetic Patients' Association-Section of Treviso Project" @default.
- W2948223141 doi "https://doi.org/10.2337/db19-621-p" @default.
- W2948223141 hasPublicationYear "2019" @default.
- W2948223141 type Work @default.
- W2948223141 sameAs 2948223141 @default.
- W2948223141 citedByCount "1" @default.
- W2948223141 countsByYear W29482231412023 @default.
- W2948223141 crossrefType "journal-article" @default.
- W2948223141 hasAuthorship W2948223141A5000726438 @default.
- W2948223141 hasAuthorship W2948223141A5010863889 @default.
- W2948223141 hasAuthorship W2948223141A5020202301 @default.
- W2948223141 hasAuthorship W2948223141A5030107487 @default.
- W2948223141 hasAuthorship W2948223141A5041605390 @default.
- W2948223141 hasAuthorship W2948223141A5073971614 @default.
- W2948223141 hasAuthorship W2948223141A5074094118 @default.
- W2948223141 hasAuthorship W2948223141A5079026709 @default.
- W2948223141 hasAuthorship W2948223141A5079827760 @default.
- W2948223141 hasAuthorship W2948223141A5090631931 @default.
- W2948223141 hasConcept C126322002 @default.
- W2948223141 hasConcept C134018914 @default.
- W2948223141 hasConcept C141071460 @default.
- W2948223141 hasConcept C164705383 @default.
- W2948223141 hasConcept C2777180221 @default.
- W2948223141 hasConcept C2779464278 @default.
- W2948223141 hasConcept C2781099653 @default.
- W2948223141 hasConcept C500558357 @default.
- W2948223141 hasConcept C555293320 @default.
- W2948223141 hasConcept C71924100 @default.
- W2948223141 hasConcept C73787029 @default.
- W2948223141 hasConcept C84393581 @default.
- W2948223141 hasConceptScore W2948223141C126322002 @default.
- W2948223141 hasConceptScore W2948223141C134018914 @default.
- W2948223141 hasConceptScore W2948223141C141071460 @default.
- W2948223141 hasConceptScore W2948223141C164705383 @default.
- W2948223141 hasConceptScore W2948223141C2777180221 @default.
- W2948223141 hasConceptScore W2948223141C2779464278 @default.
- W2948223141 hasConceptScore W2948223141C2781099653 @default.
- W2948223141 hasConceptScore W2948223141C500558357 @default.
- W2948223141 hasConceptScore W2948223141C555293320 @default.
- W2948223141 hasConceptScore W2948223141C71924100 @default.
- W2948223141 hasConceptScore W2948223141C73787029 @default.
- W2948223141 hasConceptScore W2948223141C84393581 @default.
- W2948223141 hasIssue "Supplement_1" @default.
- W2948223141 hasLocation W29482231411 @default.
- W2948223141 hasOpenAccess W2948223141 @default.
- W2948223141 hasPrimaryLocation W29482231411 @default.
- W2948223141 hasRelatedWork W1966234050 @default.
- W2948223141 hasRelatedWork W1989440849 @default.
- W2948223141 hasRelatedWork W2003150205 @default.
- W2948223141 hasRelatedWork W2008851126 @default.
- W2948223141 hasRelatedWork W2049397185 @default.
- W2948223141 hasRelatedWork W2075790801 @default.
- W2948223141 hasRelatedWork W2153591790 @default.
- W2948223141 hasRelatedWork W2171089442 @default.
- W2948223141 hasRelatedWork W2399063111 @default.
- W2948223141 hasRelatedWork W2487599708 @default.
- W2948223141 hasVolume "68" @default.
- W2948223141 isParatext "false" @default.
- W2948223141 isRetracted "false" @default.
- W2948223141 magId "2948223141" @default.
- W2948223141 workType "article" @default.