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- W2948252048 abstract "The receptor for advanced glycation end-product (RAGE) was one of the signal transduction receptors. RAGE interacted with various signaling molecules which were involved in human disease processes including tumorigenesis. Previous reports have indicated that RAGE/high-mobility group box 1 (HMGB1) could regulate autophagy in different carcinomas. However, the functional role of RAGE/ HMGB1 in the regulation of clear cell renal cell carcinoma (ccRCC) autophagy remained unrevealed.Western blot, quantitative real-time polymerase chain reaction (qRT-PCR) and immunofluorescence were used in the present study.In this study, we demonstrated that the levels of RAGE/HMGB1 and autophagic protein LC3, Beclin-1, PI3K were much higher in ccRCC samples than those of in adjacent normal tissues. RAGE and autophagic protein expression was regulated with RAGE/HMGB1 in human RCC cell lines.Our results implicated that RAGE and autophagy played important roles in ccRCC, and RAGE/HMGB1 might serve as a novel therapeutic target for future ccRCC treatment." @default.
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- W2948252048 date "2019-01-01" @default.
- W2948252048 modified "2023-10-14" @default.
- W2948252048 title "Receptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinoma" @default.
- W2948252048 doi "https://doi.org/10.4103/jcrt.jcrt_180_18" @default.
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