Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948263124> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2948263124 abstract "Acetaminophen is an analgesic and antipyretic drug, its overdose cause hepatotoxicity. The current antidote for acetaminophen hepatotoxicity is N-acetyl cysteine (NAC); however, NAC has been resulted in severe side effects as seizures, intracranial hypertension and cerebral edema. This study aimed to assess and compare the ameliorative effects of cimetidine and silymarin against acute acetaminophen–induced hepatotoxicity. Fifty four adult albino rats were divided into nine groups: negative control; solvent control; silymarin control; cimetidine control; cimetidine and silymarin control; acetaminophen group; acetaminophen and silymarin group; acetaminophen and cimetidine group; acetaminophen, cimetidine and silymarin group. A single dose of: acetaminophen (800 mg/kg, orally); silymarin (150mg/kg, orally) and cimetidine (150 mg/kg, intraperitoneally) were given according to study regimen. Liver histopathology, biochemical analysis of liver aminotransferases (AST & ALT) and hepatic tissue levels of oxidative stress index (MDA) and antioxidant (GSH) were assessed. Treatment with cimetidine alone gave better biochemical results as compared to treatment with silymarin alone. However combined treatment with cimetidine and silymarin showed better ameliorative effects than either of them given alone, evidenced by better improvement in histopathological examination and biochemical results as compared to other tested groups, and these results were non-significant as compared to controls. In conclusion treatment with silymarin and cimetidine in-combination for acute acetaminophen–induced hepatotoxicity showed better improvement probably due to synergistic hepatoprotective effects." @default.
- W2948263124 created "2019-06-14" @default.
- W2948263124 creator A5000352251 @default.
- W2948263124 creator A5017945611 @default.
- W2948263124 creator A5040589493 @default.
- W2948263124 creator A5054092089 @default.
- W2948263124 creator A5056089626 @default.
- W2948263124 date "2019-06-01" @default.
- W2948263124 modified "2023-09-24" @default.
- W2948263124 title "Ameliorative Effect of Cimetidine and Silymarin on Acute Acetaminophen-induced Hepatotoxicity in Adult Albino Rats: An Experimental Comparative Study" @default.
- W2948263124 cites W1492127447 @default.
- W2948263124 cites W1520696705 @default.
- W2948263124 cites W1527821398 @default.
- W2948263124 cites W1536199286 @default.
- W2948263124 cites W1599629450 @default.
- W2948263124 cites W1966042964 @default.
- W2948263124 cites W2033516220 @default.
- W2948263124 cites W2057119498 @default.
- W2948263124 cites W2061042774 @default.
- W2948263124 cites W2076369878 @default.
- W2948263124 cites W2085604678 @default.
- W2948263124 cites W2086938391 @default.
- W2948263124 cites W2095454001 @default.
- W2948263124 cites W2096557544 @default.
- W2948263124 cites W2143894406 @default.
- W2948263124 cites W2147970956 @default.
- W2948263124 cites W2187916557 @default.
- W2948263124 cites W2188722286 @default.
- W2948263124 cites W2266929960 @default.
- W2948263124 cites W2310910692 @default.
- W2948263124 cites W2564037803 @default.
- W2948263124 cites W2766458512 @default.
- W2948263124 cites W2888817700 @default.
- W2948263124 cites W774458479 @default.
- W2948263124 cites W92651620 @default.
- W2948263124 cites W2185679524 @default.
- W2948263124 doi "https://doi.org/10.21608/ejfsat.2019.7157.1047" @default.
- W2948263124 hasPublicationYear "2019" @default.
- W2948263124 type Work @default.
- W2948263124 sameAs 2948263124 @default.
- W2948263124 citedByCount "1" @default.
- W2948263124 countsByYear W29482631242021 @default.
- W2948263124 crossrefType "journal-article" @default.
- W2948263124 hasAuthorship W2948263124A5000352251 @default.
- W2948263124 hasAuthorship W2948263124A5017945611 @default.
- W2948263124 hasAuthorship W2948263124A5040589493 @default.
- W2948263124 hasAuthorship W2948263124A5054092089 @default.
- W2948263124 hasAuthorship W2948263124A5056089626 @default.
- W2948263124 hasBestOaLocation W29482631241 @default.
- W2948263124 hasConcept C126322002 @default.
- W2948263124 hasConcept C2778722691 @default.
- W2948263124 hasConcept C2779252780 @default.
- W2948263124 hasConcept C2779365888 @default.
- W2948263124 hasConcept C2780719153 @default.
- W2948263124 hasConcept C2780820201 @default.
- W2948263124 hasConcept C29730261 @default.
- W2948263124 hasConcept C71924100 @default.
- W2948263124 hasConcept C98274493 @default.
- W2948263124 hasConceptScore W2948263124C126322002 @default.
- W2948263124 hasConceptScore W2948263124C2778722691 @default.
- W2948263124 hasConceptScore W2948263124C2779252780 @default.
- W2948263124 hasConceptScore W2948263124C2779365888 @default.
- W2948263124 hasConceptScore W2948263124C2780719153 @default.
- W2948263124 hasConceptScore W2948263124C2780820201 @default.
- W2948263124 hasConceptScore W2948263124C29730261 @default.
- W2948263124 hasConceptScore W2948263124C71924100 @default.
- W2948263124 hasConceptScore W2948263124C98274493 @default.
- W2948263124 hasLocation W29482631241 @default.
- W2948263124 hasOpenAccess W2948263124 @default.
- W2948263124 hasPrimaryLocation W29482631241 @default.
- W2948263124 hasRelatedWork W1526931713 @default.
- W2948263124 hasRelatedWork W2012972697 @default.
- W2948263124 hasRelatedWork W2056286897 @default.
- W2948263124 hasRelatedWork W2068256034 @default.
- W2948263124 hasRelatedWork W2085604678 @default.
- W2948263124 hasRelatedWork W2134545122 @default.
- W2948263124 hasRelatedWork W2155549102 @default.
- W2948263124 hasRelatedWork W2553454138 @default.
- W2948263124 hasRelatedWork W2623021529 @default.
- W2948263124 hasRelatedWork W2799911900 @default.
- W2948263124 hasRelatedWork W2804077260 @default.
- W2948263124 hasRelatedWork W2886323353 @default.
- W2948263124 hasRelatedWork W2925388389 @default.
- W2948263124 hasRelatedWork W2965091131 @default.
- W2948263124 hasRelatedWork W2974395995 @default.
- W2948263124 hasRelatedWork W3017226929 @default.
- W2948263124 hasRelatedWork W3083009920 @default.
- W2948263124 hasRelatedWork W3158734039 @default.
- W2948263124 hasRelatedWork W3170956343 @default.
- W2948263124 hasRelatedWork W2558094565 @default.
- W2948263124 isParatext "false" @default.
- W2948263124 isRetracted "false" @default.
- W2948263124 magId "2948263124" @default.
- W2948263124 workType "article" @default.